Proposed signaling scheme for ischemic preconditioning

Proposed signaling scheme for ischemic preconditioning. Note that in the schematic, nitric oxide synthase (NOS) signals through protein kinase G (PKG) upstream in the trigger pathway but acts in a PKG-independent manner downstream in the mediator pathway at reperfusion. The role of glycogen synthase kinase-3β (GSK-3β) is controversial, but if it is in the pathway, then it must be downstream of the newly described NOS site. AR, adenosine receptor; PI3-K, phosphatidylinositol 3-kinase; PLC, phospholipase C; PLD, phospholipase D; ERK, extracellular signal-regulated kinase; GC, guanylyl cyclase; PKC, protein kinase C; mKATP, mitochondrial ATP-dependent K+ channel; mPTP, mitochondrial permeability transition pore; RISK, reperfusion injury survival kinases.
Proposed signaling scheme for ischemic preconditioning
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Cardioprotective PKG-independent NO signaling at reperfusion. (2010) Michael V. Cohen, et al. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2028-H2036. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PLC PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC PLC famplex_relations PLCG2 5336
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates PLD PLD ncbigene_synonym GPLD1 2822
Homo sapiens Primates PLD PLD famplex_relations PLD1 5337
Homo sapiens Primates PLD PLD famplex_relations PLD2 5338
Homo sapiens Primates PLD PLD famplex_relations PLD3 23646
Homo sapiens Primates PLD PLD famplex_relations PLD4 122618
Homo sapiens Primates PLD PLD famplex_relations PLD5 200150
Homo sapiens Primates PLD PLD famplex_relations PLD6 201164
Homo sapiens Primates AMP AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3-K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3-K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates NOS NOS ncbigene_synonym NOS1 4842
Homo sapiens Primates NOS NOS ncbigene_synonym NOS2 4843
Homo sapiens Primates NOS NOS famplex_relations NOS3 4846
Homo sapiens Primates GC GC ncbigene_symbol GC 2638
Homo sapiens Primates PKG PKG ncbigene_synonym PRKG1 5592
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Homo sapiens Primates ARA ARA ncbigene_synonym ABCC6 368
Homo sapiens Primates ARA ARA ncbigene_synonym FOXC1 2296
Homo sapiens Primates ARA ARA ncbigene_synonym PAK3 5063
Oryctolagus cuniculus Mammals NOS NOS ncbigene_synonym NOS1 100009243
Oryctolagus cuniculus Mammals GC GC ncbigene_symbol GC 100008994
Oryctolagus cuniculus Mammals GSK3B GSK3B ncbigene_symbol GSK3B 100348842
Oryctolagus cuniculus Mammals AR AR ncbigene_symbol AR 100009193
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym sl 32601
Drosophila melanogaster Invertebrates PLC PLC ncbigene_synonym Plc21C 33204
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates PLD PLD ncbigene_symbol Pld 35554
Drosophila melanogaster Invertebrates AMP AMP ncbigene_synonym Amph 36383
Drosophila melanogaster Invertebrates PI3-K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3-K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3-K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3-K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates NOS NOS ncbigene_symbol Nos 34495
Drosophila melanogaster Invertebrates NOS NOS ncbigene_symbol nos 42297
Drosophila melanogaster Invertebrates GC GC ncbigene_symbol GC 38194
Drosophila melanogaster Invertebrates PKG PKG ncbigene_synonym Pkg21D 33253
Drosophila melanogaster Invertebrates PKG PKG ncbigene_synonym for 44817
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym gskt 318552
Drosophila melanogaster Invertebrates AR AR ncbigene_symbol ar 44503
Drosophila melanogaster Invertebrates ARA ARA ncbigene_symbol ara 39439

Chemical mentions

Word Match MeSH Name ChEBI
MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mesh:D015632 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine chebi:17963

Disease mentions

Word Match MeSH Name DOID
Cancer NA