Fucose is on the TRAIL of colon cancer

GDP-fucose can be synthesized in the cytoplasm from GDP-mannose (de novo pathway) or from free fucose (salvage pathway). Once synthesized, GDP-fucose is transported into the lumen of the ER/Golgi (drawn as a single compartment for simplicity) through one or more transporters (the ER transporter has not been identified). Fucose is transferred from GDP-fucose to acceptor substrates in the lumen of the ER (Pofut1, Pofut2) or Golgi (all other fucosyltransferases). Pofut1 fucosylates serine/threonines in Epidermal Growth Factor-like (EGF) repeats, and Pofut2 fucosylates serine/threonines in Thrombospondin type 1 repeats (TSRs). Fucosylation leads to formation of cell-surface or secreted glycoproteins, some of which are shown on the surface of the cell or secreted. Although fucose occurs in many different types of structures, some specific examples are shown, including (from left to right): mucin-type O-glycans, N-glycans (both core and terminal fucosylation), O-fucose on TSRs, and O-fucose on EGF repeats. Note that Lewis type structures can occur on both N-glycan or mucin-type O-glycan cores. Known functions of fucosylated glycans are shown above each structure, including selectin recognition, pathogen binding, and a variety of signaling events (Notch, TGF-β1, EGF, integrins). For a more extensive review of fucosylation, see Becker and Lowe. Adapted from Smith et al. with permission **note: permission pending**.

Publication

Fucose is on the TRAIL of colon cancer. () Robert S. Haltiwanger. Gastroenterology. ;137(1):36-39. Figure: F1. All organisms Cricetulus griseus Homo sapiens Mus musculus Drosophila melanogaster

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