Proposed model of GS-mediated apoptosis in HNSCC cells

The proposed model of GS-mediated apoptosis in HNSCC cells. Our results demonstrated GS targets 14-3-3 zeta to initiate apoptosis through the intrinsic mitochondrial pathway by releasing Bad from its inhibitory action. Activation of PP2A inhibited association of Bad with 14-3-3 zeta resulting in its accumulation on outer mitochondrial membrane, altering its membrane potential. This releases cytochrome c, activating the downstream caspases - caspase 9 and caspase 3. In addition, treatment with GS induces expression of CD95/Fas receptors leading to caspase 8 activation in head and neck cancer cells.
Proposed model of GS-mediated apoptosis in HNSCC cells
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Publication

14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells. (2010) Muzafar A Macha, et al. BMC Cancer. 2010;10:655-655. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents GS GS ncbigene_symbol gs 14835
Mus musculus Rodents GS GS ncbigene_symbol Gs 109550
Mus musculus Rodents FADD FADD ncbigene_symbol Fadd 14082
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PP2A PP2A ncbigene_synonym Ppp2ca 19052
Mus musculus Rodents PP2A PP2A ncbigene_synonym Ppp2r1a 51792
Mus musculus Rodents Bad BAD ncbigene_symbol Bad 12015
Mus musculus Rodents Bax BAX ncbigene_symbol Bax 12028
Mus musculus Rodents Bax BAX ncbigene_synonym Nkx3-1 18095
Mus musculus Rodents Caspase3 CASPASE3 ncbigene_synonym Casp3 12367
Mus musculus Rodents Caspase9 CASPASE9 ncbigene_synonym Casp9 12371
Mus musculus Rodents Bid BID ncbigene_symbol Bid 12122
Mus musculus Rodents Apaf-1 APAF-1 ncbigene_synonym Apaf1 11783
Bos taurus Mammals FADD FADD ncbigene_symbol FADD 493720
Bos taurus Mammals AKT AKT ncbigene_synonym AKT1 280991
Bos taurus Mammals Bad BAD ncbigene_symbol BAD 615013
Bos taurus Mammals Bax BAX ncbigene_symbol BAX 280730
Bos taurus Mammals Bid BID ncbigene_symbol BID 510373
Bos taurus Mammals Apaf-1 APAF1 ncbigene_symbol APAF1 537782
Homo sapiens Primates GS GS famplex_relations GNAS 2778
Homo sapiens Primates GS GS famplex_relations GNAL 2774
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF1A 7132
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF1B 7133
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF10A 8797
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF10B 8795
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF10C 8794
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations TNFRSF10D 8793
Homo sapiens Primates Deathreceptors DEATHRECEPTOR famplex_relations FAS 355
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates Bad BAD ncbigene_symbol BAD 572
Homo sapiens Primates Bax BAX ncbigene_symbol BAX 581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates Bid BID ncbigene_symbol BID 637
Homo sapiens Primates Apaf-1 APAF-1 ncbigene_synonym APAF1 317
Drosophila melanogaster Invertebrates GS GS ncbigene_symbol gs 5656925
Drosophila melanogaster Invertebrates FADD FADD ncbigene_symbol Fadd 42594
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wrd 42169
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wdb 43312
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym mts 45959
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym tws 47877
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym Pp2A-29B 2768940
Drosophila melanogaster Invertebrates Bad BAD ncbigene_synonym cass 35053
Drosophila melanogaster Invertebrates Caspase3 CASPASE3 ncbigene_synonym Decay 42008
Drosophila melanogaster Invertebrates Caspase9 CASPASE9 ncbigene_synonym Dronc 39173
Drosophila melanogaster Invertebrates Apaf-1 APAF-1 ncbigene_synonym Dark 36914

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID