Canonical pathways for cardiovascular disease

Canonical pathways for cardiovascular disease. Schematic representation of networking in which SERPINE1 and SERPINF2 are found to be the key molecules in the extracellular space and the other members are linked with SERPINE1 by dotted and solid lines. The cardiovascular pathway is integrated by obesity and diabetes pathways. KF2B (cytoplasm) induces FN 1 (part of diabetes pathway) to induce SERPINE1 (part of both obesity and diabetes pathway) (extracellular space). Also, FN 1 induces SERPINF2 and SERPING 1 through PLG (extracellular space). SERPINE1 is induced by CLL (extracellular space) and indirectly by FN1 and PLG. However, all SERPINE1, SERPING1 and SERPINF2 interconnected with each other. Although SERPING1 interconnection was not clear in the diabetes pathway. Data is the sum of three independently performed experiments.

Publication

SERPINE 1 Links Obesity and Diabetes: A Pilot Study. () Punit Kaur, et al. J Proteomics Bioinform. ;3(6):191-199. Figure: F4. All organisms Mus musculus Homo sapiens Drosophila melanogaster

Disease mentions