The estrogen biosynthesis pathway

The estrogen biosynthesis pathway. The pathway from cholesterol through estrogen synthesis and metabolism is shown with the enzymes involved. Bolded enzymes are those in which SNPs were investigated in relation to estrogen measures and lung cancer survival ().
The estrogen biosynthesis pathway
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Publication

Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. (2010) Susan E. Olivo-Marston, et al. Carcinogenesis. 2010 Oct;31(10):1778-1786. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates CYP17 CYP17 ncbigene_synonym CYP17A1 1586
Homo sapiens Primates HSD3B1 HSD3B1 ncbigene_symbol HSD3B1 3283
Homo sapiens Primates HSD17B1 HSD17B1 ncbigene_symbol HSD17B1 3292
Homo sapiens Primates CYP19 CYP19 ncbigene_synonym CYP19A1 1588
Homo sapiens Primates CYP1B1 CYP1B1 ncbigene_symbol CYP1B1 1545
Homo sapiens Primates COMT COMT ncbigene_symbol COMT 1312
Danio rerio Vertebrates CYP17 CYP17 ncbigene_synonym cyp17a1 399692
Danio rerio Vertebrates HSD3B1 HSD3B1 ncbigene_symbol hsd3b1 553532
Danio rerio Vertebrates HSD3B1 HSD3B1 ncbigene_synonym hsd3b2 373131
Danio rerio Vertebrates HSD17B1 HSD17B1 ncbigene_symbol hsd17b1 402842
Danio rerio Vertebrates CYP19 CYP19 ncbigene_synonym cyp19a1a 30390
Danio rerio Vertebrates CYP19 CYP19 ncbigene_synonym cyp19a1b 60640
Danio rerio Vertebrates CYP1B1 CYP1B1 ncbigene_symbol cyp1b1 100150054
Danio rerio Vertebrates COMT COMT ncbigene_synonym comta 561372

Chemical mentions

Word Match MeSH Name ChEBI
4-hydroxyestradiol 4-hydroxy-17beta-estradiol mesh:C014036 4-hydroxyestradiol chebi:62845
4-methoxyestradiol 4-methoxy-17beta-estradiol mesh:C045018 4-methoxyestradiol chebi:136975
Androstenedione Androstenedione mesh:D000735 androst-4-ene-3,17-dione chebi:16422
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
DHEA Dehydroepiandrosterone mesh:D003687 dehydroepiandrosterone chebi:28689
Estradiol Estradiol mesh:D004958 17beta-estradiol chebi:16469
Pregnenolone Pregnenolone mesh:D011284 pregnenolone chebi:16581
pregnenolone Pregnenolone mesh:D011284 pregnenolone chebi:16581
Progesterone Progesterone mesh:D011374 progesterone chebi:17026
progesterone Progesterone mesh:D011374 progesterone chebi:17026
Testosterone Testosterone mesh:D013739 testosterone chebi:17347
Androstenediol Androstenediol mesh:D015114 androst-5-ene-3beta,17beta-diol chebi:2710

Disease mentions

Word Match MeSH Name DOID