Signaling pathway and transcription factors involved in HPR1 gene expression in cancer
Signaling pathway and transcription factors involved in HPR1 gene expression in cancer. Mutations and/or overexpression of the growth factor receptor genes such as EGFR and its downstream signaling molecules such as RAS and BRAF genes result in increased expression and/or translocation of the Ets family transcription factors such as GABP and Ets-1. These transcription factors in cooperation with several other transcription factors overexpressed in cancer, such as Sp1 and Egr-1, lead to HPR1 expression in cancer. HPR1 promoter demethylation and p53 mutations also contribute to increased HPR1 gene expression (not shown).
Publication
Induction of Heparanase-1 Expression by Mutant B-Raf Kinase: Role of GA Binding Protein in Heparanase-1 Promoter Activation. (2010) Geetha Rao, et al. Neoplasia. 2010 Nov;12(11):946-956. Figure: F7.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | (EGFR, | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | PDGFR) | PDGFR | ncbigene_synonym | PDGFRB | 5159 |
| Homo sapiens | Primates | PDGFR) | PDGFR | famplex_relations | PDGFRA | 5156 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | Raf(B-Raf,Raf-1,C-Raf) | RAF-1 | ncbigene_synonym | RAF1 | 5894 |
| Homo sapiens | Primates | Raf | RAF | ncbigene_synonym | ZHX2 | 22882 |
| Homo sapiens | Primates | Raf | RAF | famplex_relations | ARAF | 369 |
| Homo sapiens | Primates | Raf | RAF | famplex_relations | BRAF | 673 |
| Homo sapiens | Primates | Ets-1) | ETS1 | ncbigene_symbol | ETS1 | 2113 |
| Homo sapiens | Primates | Sp1 | SP1 | ncbigene_symbol | SP1 | 6667 |
| Homo sapiens | Primates | Sp1 | SP1 | ncbigene_synonym | PSG1 | 5669 |
| Homo sapiens | Primates | Sp1 | SP1 | ncbigene_synonym | DAND5 | 199699 |
| Homo sapiens | Primates | COD | COD | ncbigene_synonym | SNRPB | 6628 |
| Homo sapiens | Primates | SplC | SPIC | ncbigene_symbol | SPIC | 121599 |
| Homo sapiens | Primates | ERE-D | ERED | ncbigene_synonym | COL17A1 | 1308 |
| Homo sapiens | Primates | Egr-1 | EGR1 | ncbigene_symbol | EGR1 | 1958 |
| Danio rerio | Vertebrates | receptor | RECEPTOR | ncbigene_synonym | kita | 30256 |
| Danio rerio | Vertebrates | receptor | RECEPTOR | ncbigene_synonym | ngfra | 100535003 |
| Danio rerio | Vertebrates | (EGFR, | EGFR | ncbigene_synonym | egfra | 378478 |
| Danio rerio | Vertebrates | Ras | RAS | ncbigene_synonym | rab1ab | 368883 |
| Danio rerio | Vertebrates | Raf(B-Raf,Raf-1,C-Raf) | CRAF | ncbigene_synonym | raf1a | 30716 |
| Danio rerio | Vertebrates | (B-Raf, | BRAF | ncbigene_symbol | braf | 403065 |
| Danio rerio | Vertebrates | (B-Raf, | BRAF | ncbigene_synonym | si:dkey-222f8.3 | 561722 |
| Danio rerio | Vertebrates | Ets-1) | ETS1 | ncbigene_symbol | ets1 | 280651 |
| Danio rerio | Vertebrates | Sp1 | SP1 | ncbigene_symbol | sp1 | 324109 |
| Danio rerio | Vertebrates | SplC | SPIC | ncbigene_symbol | spic | 447882 |
| Danio rerio | Vertebrates | Egr-1 | EGR1 | ncbigene_symbol | egr1 | 30498 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |