Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity

Gene expression within cluster MCL2 is enriched in genes affecting NK cell-mediated cytotoxicity. Fold change in gene expression from MCL2 is shown on the KEGG pathway map (modified from map04650, natural killer cell-mediated cytotoxicity, at the Kyoto Encyclopedia of Genes and Genomes [KEGG] website http://www.genome.jp/kegg/kegg1.html, with permission). KIR2DL, phosphatidylinositol 3-kinase (PI3K), and phospholipase Cγ (PLCγ) depicted in this pathway are represented by multiple gene transcripts in MCL2; in these cases genes are colored according to the transcript with the largest fold change in expression within a multigene or transcript family (KIR2DL4, PI3KCD, and PLCG2). Participants with disease and infection had the greatest changes in gene expression (shown on the map by increasing intensities of red). Onto-tools Pathway Express expression perturbation analysis based only on differentially regulated genes (<0.5 and >2.0 at an adjusted P value of <0.01) comparing healthy subjects with diseased and infected subjects also identifies NK cell-mediated cytotoxicity as substantially affected. An overlapping effect on antigen processing and presentation related primarily to NK cell activity was also observed. The impact factor is the estimated effect on each pathway as a result of changes in transcript expression in addition to enrichment.

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Human Conjunctival Transcriptome Analysis Reveals the Prominence of Innate Defense in Chlamydia trachomatis Infection . (2010) Angels Natividad, et al. Infect Immun. 2010 Nov;78(11):4895-4911. Figure: F5. All organisms Homo sapiens Drosophila melanogaster

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