The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities

FoxA2/HIF-1α interaction together with the recruitment of p300/CPB promotes the transcription of select HIF targets such as Hes6, Sox9, Jmjd1a and Plod2. The selective transcriptional program elicited by HIF/FoxA2 is required for the development of prostate NE tumors and formation of NED lesions in the PCa. Arrows point to components in this pathway that can be used for diagnosis and therapeutic targeting.
The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities
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Publication

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities. (2010) Jianfei Qi, et al. Oncotarget. 2010 Sep;1(5):379-385. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents Siah SIAH ncbigene_synonym Siah1 140941
Rattus norvegicus Rodents Siah2 SIAH2 ncbigene_symbol Siah2 140593
Rattus norvegicus Rodents HIF1A HIF1A ncbigene_symbol Hif1a 29560
Rattus norvegicus Rodents FoxA2 FOXA2 ncbigene_symbol Foxa2 25099
Rattus norvegicus Rodents The THE ncbigene_synonym Th 25085
Rattus norvegicus Rodents Hes6 HES6 ncbigene_symbol Hes6 316626
Rattus norvegicus Rodents Jmjdla JMJD1A ncbigene_synonym Kdm3a 312440
Rattus norvegicus Rodents Sox9 SOX9 ncbigene_symbol Sox9 140586
Rattus norvegicus Rodents Plod2 PLOD2 ncbigene_symbol Plod2 300901
Homo sapiens Primates Siah2 SIAH2 ncbigene_symbol SIAH2 6478
Homo sapiens Primates Окуgen GEN ncbigene_synonym GEN1 348654
Homo sapiens Primates HIF1A HIF1A ncbigene_symbol HIF1A 3091
Homo sapiens Primates FoxA2 FOXA2 ncbigene_symbol FOXA2 3170
Homo sapiens Primates p300 P300 ncbigene_synonym EP300 2033
Homo sapiens Primates Hes6 HES6 ncbigene_symbol HES6 55502
Homo sapiens Primates Jmjdla JMJD1A ncbigene_synonym KDM3A 55818
Homo sapiens Primates Sox9 SOX9 ncbigene_symbol SOX9 6662
Homo sapiens Primates Plod2 PLOD2 ncbigene_symbol PLOD2 5352
Mus musculus Rodents Siah2 SIAH2 ncbigene_symbol Siah2 20439
Mus musculus Rodents HIF1A HIF1A ncbigene_symbol Hif1a 15251
Mus musculus Rodents FoxA2 FOXA2 ncbigene_symbol Foxa2 15376
Mus musculus Rodents p300 P300 ncbigene_synonym Ep300 328572
Mus musculus Rodents Hes6 HES6 ncbigene_symbol Hes6 55927
Mus musculus Rodents Jmjdla JMJD1A ncbigene_synonym Kdm3a 104263
Mus musculus Rodents Sox9 SOX9 ncbigene_symbol Sox9 20682
Mus musculus Rodents Plod2 PLOD2 ncbigene_symbol Plod2 26432
Drosophila melanogaster Invertebrates Siah SIAH ncbigene_synonym sina 39884
Drosophila melanogaster Invertebrates Siah SIAH ncbigene_synonym ci 43767
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates NE NE ncbigene_symbol Ne 249975
Drosophila melanogaster Invertebrates Окуgen GEN ncbigene_symbol Gen 38594
Drosophila melanogaster Invertebrates HIF1A HIF1A ncbigene_synonym sima 43580
Drosophila melanogaster Invertebrates p300 P300 ncbigene_synonym osa 42130
Drosophila melanogaster Invertebrates p300 P300 ncbigene_synonym nej 43856
Drosophila melanogaster Invertebrates Sox9 SOX9 ncbigene_synonym Sox100B 45039
Drosophila melanogaster Invertebrates NED NED ncbigene_symbol ned 44410
Danio rerio Vertebrates HIF1A HIF1A ncbigene_synonym hif1ab 393202
Danio rerio Vertebrates FoxA2 FOXA2 ncbigene_symbol foxa2 30126
Danio rerio Vertebrates Hes6 HES6 ncbigene_symbol hes6 373116
Danio rerio Vertebrates Plod2 PLOD2 ncbigene_symbol plod2 100036767

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID