Runx2-regulated cancer-related gene network

Runx2-regulated cancer-related gene network. The 119 cancer-related genes showing a significant ≥2-fold response to Runx2 on day 1 were subjected to the pathway analysis tool from Ingenuity Systems (IPA™). Direct relationships with Runx2 are shown as thick lines and interactions with its paralogs Runx1 and Runx3 are shown as dashed lines. Red and blue fonts mark up- and down-regulated genes, respectively.
Runx2-regulated cancer-related gene network
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Publication

Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. (2010) Sanjeev K Baniwal, et al. Mol Cancer. 2010;9:258-258. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates NPTX2 NPTX2 ncbigene_symbol NPTX2 4885
Homo sapiens Primates EDN2 EDN2 ncbigene_symbol EDN2 1907
Homo sapiens Primates ČSF2 CSF2 ncbigene_symbol CSF2 1437
Homo sapiens Primates GDF15 GDF15 ncbigene_symbol GDF15 9518
Homo sapiens Primates TFPI TFPI ncbigene_symbol TFPI 7035
Homo sapiens Primates LOXL4 LOXL4 ncbigene_symbol LOXL4 84171
Homo sapiens Primates CST7 CST7 ncbigene_symbol CST7 8530
Homo sapiens Primates HTRA1 HTRA1 ncbigene_symbol HTRA1 5654
Homo sapiens Primates ITIH4 ITIH4 ncbigene_symbol ITIH4 3700
Homo sapiens Primates THBS1 THBS1 ncbigene_symbol THBS1 7057
Homo sapiens Primates LCN2 LCN2 ncbigene_symbol LCN2 3934
Homo sapiens Primates ĪGFÍ IGFI ncbigene_synonym IGF1 3479
Homo sapiens Primates VEGFA VEGFA ncbigene_symbol VEGFA 7422
Homo sapiens Primates IL3 IL3 ncbigene_symbol IL3 3562
Homo sapiens Primates MMP13 MMP13 ncbigene_symbol MMP13 4322
Homo sapiens Primates SHBG SHBG ncbigene_symbol SHBG 6462
Homo sapiens Primates PGC PGC ncbigene_symbol PGC 5225
Homo sapiens Primates TNFSF10 TNFSF10 ncbigene_symbol TNFSF10 8743
Homo sapiens Primates BAMBI BAMBI ncbigene_symbol BAMBI 25805
Homo sapiens Primates LRP8 LRP8 ncbigene_symbol LRP8 7804
Homo sapiens Primates CXCR7 CXCR7 ncbigene_synonym ACKR3 57007
Homo sapiens Primates GRIN3A GRIN3A ncbigene_symbol GRIN3A 116443
Homo sapiens Primates ST14 ST14 ncbigene_symbol ST14 6768
Homo sapiens Primates SLC40A1 SLC40A1 ncbigene_symbol SLC40A1 30061
Homo sapiens Primates CD82 CD82 ncbigene_symbol CD82 3732
Homo sapiens Primates TM4SF1 TM4SF1 ncbigene_symbol TM4SF1 4071
Homo sapiens Primates SLC16A3 SLC16A3 ncbigene_symbol SLC16A3 9123
Homo sapiens Primates VTCN1 VTCN1 ncbigene_symbol VTCN1 79679
Homo sapiens Primates ALCAM ALCAM ncbigene_symbol ALCAM 214
Homo sapiens Primates GJB2| GJB2 ncbigene_symbol GJB2 2706
Homo sapiens Primates LYAR LYAR ncbigene_symbol LYAR 55646
Homo sapiens Primates DLG2 DLG2 ncbigene_symbol DLG2 1740
Homo sapiens Primates DLG2 DLG2 ncbigene_synonym MPP2 4355
Homo sapiens Primates ACHE ACHE ncbigene_symbol ACHE 43
Homo sapiens Primates PTGER4 PTGER4 ncbigene_symbol PTGER4 5734
Homo sapiens Primates DMBT1 DMBT1 ncbigene_symbol DMBT1 1755
Homo sapiens Primates MERTK MERTK ncbigene_symbol MERTK 10461
Homo sapiens Primates PTGS1 PTGS1 ncbigene_symbol PTGS1 5742
Homo sapiens Primates SLPI SLPI ncbigene_symbol SLPI 6590
Homo sapiens Primates AACS AACS ncbigene_symbol AACS 65985
Homo sapiens Primates PRKCD PRKCD ncbigene_symbol PRKCD 5580
Homo sapiens Primates NES NES ncbigene_symbol NES 10763
Homo sapiens Primates SPSB1 SPSB1 ncbigene_symbol SPSB1 80176
Homo sapiens Primates GBP2 GBP2 ncbigene_symbol GBP2 2634
Homo sapiens Primates TGM2 TGM2 ncbigene_symbol TGM2 7052
Homo sapiens Primates JAMP JAMP ncbigene_synonym JKAMP 51528
Homo sapiens Primates SPHK1 SPHK1 ncbigene_symbol SPHK1 8877
Homo sapiens Primates PMAIP1 PMAIP1 ncbigene_symbol PMAIP1 5366
Homo sapiens Primates CLGN CLGN ncbigene_symbol CLGN 1047
Homo sapiens Primates CLGN CLGN ncbigene_synonym MMP1 4312
Homo sapiens Primates EPHX1 EPHX1 ncbigene_symbol EPHX1 2052
Homo sapiens Primates DUSP DUSP ncbigene_synonym DUSP5 1847
Homo sapiens Primates DUSP DUSP famplex_relations DUSP1 1843
Homo sapiens Primates DUSP DUSP famplex_relations DUSP2 1844
Homo sapiens Primates DUSP DUSP famplex_relations DUSP3 1845
Homo sapiens Primates DUSP DUSP famplex_relations DUSP4 1846
Homo sapiens Primates DUSP DUSP famplex_relations DUSP6 1848
Homo sapiens Primates SPDEF SPDEF ncbigene_symbol SPDEF 25803
Homo sapiens Primates EZH2 EZH2 ncbigene_symbol EZH2 2146
Homo sapiens Primates GMNN GMNN ncbigene_symbol GMNN 51053
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609
Homo sapiens Primates E2F2 E2F2 ncbigene_symbol E2F2 1870
Homo sapiens Primates NKX3-1 NKX3-1 ncbigene_symbol NKX3-1 4824
Homo sapiens Primates BARD1 BARD1 ncbigene_symbol BARD1 580
Homo sapiens Primates SKP2 SKP2 ncbigene_symbol SKP2 6502
Homo sapiens Primates SKP2 SKP2 ncbigene_synonym UXT 8409
Homo sapiens Primates CDCA7 CDCA7 ncbigene_symbol CDCA7 83879
Homo sapiens Primates POLE2 POLE2 ncbigene_symbol POLE2 5427
Homo sapiens Primates MCM MCM ncbigene_synonym MMUT 4594
Homo sapiens Primates MCM MCM ncbigene_synonym PIK3CA 5290
Homo sapiens Primates MCM MCM famplex_relations MCM2 4171
Homo sapiens Primates MCM MCM famplex_relations MCM3 4172
Homo sapiens Primates MCM MCM famplex_relations MCM4 4173
Homo sapiens Primates MCM MCM famplex_relations MCM5 4174
Homo sapiens Primates MCM MCM famplex_relations MCM6 4175
Homo sapiens Primates MCM MCM famplex_relations MCM7 4176
Homo sapiens Primates MCM MCM famplex_relations MCM8 84515
Homo sapiens Primates MCM MCM famplex_relations MCM9 254394
Homo sapiens Primates MCM MCM famplex_relations MCMDC2 157777
Homo sapiens Primates ATF3 ATF3 ncbigene_symbol ATF3 467
Homo sapiens Primates SNAI2 SNAI2 ncbigene_symbol SNAI2 6591
Homo sapiens Primates VRK1 VRK1 ncbigene_symbol VRK1 7443
Homo sapiens Primates HIPK2 HIPK2 ncbigene_symbol HIPK2 28996
Homo sapiens Primates PSMC3IP PSMC3IP ncbigene_symbol PSMC3IP 29893
Homo sapiens Primates CTDSPL CTDSPL ncbigene_symbol CTDSPL 10217
Homo sapiens Primates TOB1 TOB1 ncbigene_symbol TOB1 10140
Homo sapiens Primates (CEBPA CEBPA ncbigene_symbol CEBPA 1050
Homo sapiens Primates MAFB MAFB ncbigene_symbol MAFB 9935
Homo sapiens Primates RGS2 RGS2 ncbigene_symbol RGS2 5997
Homo sapiens Primates RGS2 RGS2 ncbigene_synonym RIEG2 6012
Homo sapiens Primates CDC6 CDC6 ncbigene_symbol CDC6 990
Homo sapiens Primates SMAD6 SMAD6 ncbigene_symbol SMAD6 4091
Homo sapiens Primates SMAD3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates NR2F1 NR2F1 ncbigene_symbol NR2F1 7025
Homo sapiens Primates STS STS ncbigene_symbol STS 412
Homo sapiens Primates C10ORF81 C10ORF81 ncbigene_synonym PLEKHS1 79949
Homo sapiens Primates RUNX3 RUNX3 ncbigene_symbol RUNX3 864
Homo sapiens Primates RUNX1 RUNX1 ncbigene_symbol RUNX1 861
Homo sapiens Primates MT1X MT1X ncbigene_symbol MT1X 4501
Homo sapiens Primates SIDT2 SIDT2 ncbigene_symbol SIDT2 51092
Homo sapiens Primates RUNX2 RUNX2 ncbigene_symbol RUNX2 860
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Cytokine/GrowthFactor GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates lon LON ncbigene_synonym LONP1 9361
Homo sapiens Primates Peptidase PEPTIDASE ncbigene_synonym OMA1 115209
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAO1 2775
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAI1 2770
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAI2 2771
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAI3 2773
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAT1 2779
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAT2 2780
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAT3 346562
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAZ 2781
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAS 2778
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAL 2774
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNAQ 2776
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNA11 2767
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNA14 9630
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNA15 2769
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNA12 2768
Homo sapiens Primates G-protein GPROTEIN famplex_relations GNA13 10672

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA