Outline of T-cell development pathway from bone marrow to the thymus

Outline of T-cell development pathway from bone marrow to the thymus. Lympho-hematopoietic progenitor cells leave the bone marrow for the thymus. Intrathymic T-cell development includes starting with none of CD4 and CD8 markers (double negative, DN), then gaining both CD4 and CD8 (double positive, DP), to losing one of them (single positive, SP). In the DN stage, there are four subsets: DN1, DN2, DN3, and DN4, based on the gain and loss of CD44 and/or CD25. DN1 contains CD117+ and CD117− subsets. The figure shows CD117+ DN1, which is the canonical subset giving rise to DN2. Expression of Bcl11b gene was shown to be increased from DN2 to DN3 stage and subsequently maintained at a high level based on the Li et al.'s paper (2010).
Outline of T-cell development pathway from bone marrow to the thymus
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Publication

A New Avenue to Cure Cancer by Turning Adaptive Immune T Cells to Innate Immune NK Cells via Reprogramming. (2010) Dong-Ming Su, et al. J Mol Cell Biol. 2010 Oct;2(5):237-239. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ThPok THPOK ncbigene_synonym ZBTB7B 51043
Homo sapiens Primates CD4* CD4 ncbigene_symbol CD4 920
Homo sapiens Primates tf TF ncbigene_symbol TF 7018
Homo sapiens Primates CD44 CD44 ncbigene_symbol CD44 960
Homo sapiens Primates CD25 CD25 ncbigene_synonym IL2RA 3559
Homo sapiens Primates CD25 CD25 ncbigene_synonym ISG20 3669
Homo sapiens Primates CD48* CD48 ncbigene_symbol CD48 962
Homo sapiens Primates CD8* CD8 ncbigene_synonym CD8A 925
Homo sapiens Primates CD8* CD8 famplex_relations CD8B 926
Homo sapiens Primates Runx3 RUNX3 ncbigene_symbol RUNX3 864
Homo sapiens Primates Bcl11b BCL11B ncbigene_symbol BCL11B 64919
Mus musculus Rodents ThPok THPOK ncbigene_synonym Zbtb7b 22724
Mus musculus Rodents CD4* CD4 ncbigene_symbol Cd4 12504
Mus musculus Rodents CD44 CD44 ncbigene_symbol Cd44 12505
Mus musculus Rodents CD25 CD25 ncbigene_synonym Il2ra 16184
Mus musculus Rodents CD48* CD48 ncbigene_symbol Cd48 12506
Mus musculus Rodents (DP) DP ncbigene_symbol dp 13450
Mus musculus Rodents Runx3 RUNX3 ncbigene_symbol Runx3 12399
Mus musculus Rodents Bcl11b BCL11B ncbigene_symbol Bcl11b 58208
Drosophila melanogaster Invertebrates DC DC ncbigene_symbol dc 44088
Drosophila melanogaster Invertebrates tf TF ncbigene_symbol tf 252813
Drosophila melanogaster Invertebrates (DP) DP ncbigene_symbol Dp 36461

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID