Transforming growth factor beta (TGFB) family cell signaling pathway

(A) Transforming growth factor beta (TGF-β) family cell signaling pathway. TGF-β family ligands bind and signal through serine/threonine kinase receptors on the plasma membrane. Signals are transduced through phosphorylated receptor Smad proteins. Receptor Smad/co-Smad dimers translocate into the nucleus to stimulate target gene transcription. (B) Receptors and Smad proteins that comprise the core signaling pathway for TGF-β and bone morphogenetic proteins (BMP) family ligands. See Shimasaki et al for a comprehensive list of TGF-β family ligands and their receptors. AMH, anti-müllerian hormone; GDF, growth differentiation factors.
Transforming growth factor beta (TGFB) family cell signaling pathway
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Publication

Roles for Transforming Growth Factor Beta Superfamily Proteins in Early Folliculogenesis. () Daniel J. Trombly, et al. Semin Reprod Med. ;27(1):14-23. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Ovis aries Mammals Receptor RECEPTOR ncbigene_symbol RECEPTOR 443145
Ovis aries Mammals ActRIIB ACTRIIB ncbigene_synonym ACVR2B 443156
Ovis aries Mammals BMPRII BMPR2 ncbigene_symbol BMPR2 101103793
Ovis aries Mammals ALK3,5,6 ALK6 ncbigene_synonym BMPR1B 443454
Ovis aries Mammals AMH AMH ncbigene_symbol AMH 101121773
Ovis aries Mammals AMHRII AMHR2 ncbigene_symbol AMHR2 101109693
Bos taurus Mammals ActRIIB ACTRIIB ncbigene_synonym ACVR2B 282131
Bos taurus Mammals Sma SMA ncbigene_symbol SMA 100308165
Bos taurus Mammals BMPRII BMPRII ncbigene_synonym BMPR2 407127
Bos taurus Mammals ALK3,5,6 ALK6 ncbigene_synonym BMPR1B 407128
Bos taurus Mammals AMH AMH ncbigene_symbol AMH 280718
Bos taurus Mammals AMHRII AMHR2 ncbigene_symbol AMHR2 514963
Homo sapiens Primates Smads SMAD famplex_relations SMAD1 4086
Homo sapiens Primates Smads SMAD famplex_relations SMAD4 4089
Homo sapiens Primates Smads SMAD famplex_relations SMAD5 4090
Homo sapiens Primates Smads SMAD famplex_relations SMAD6 4091
Homo sapiens Primates Smads SMAD famplex_relations SMAD7 4092
Homo sapiens Primates Smads SMAD famplex_relations SMAD9 4093
Homo sapiens Primates Smads SMAD famplex_relations SMAD2 4087
Homo sapiens Primates Smads SMAD famplex_relations SMAD3 4088
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043
Homo sapiens Primates TBRII TBRII ncbigene_synonym TGFBR2 7048
Homo sapiens Primates ALK5 ALK5 ncbigene_synonym TGFBR1 7046
Homo sapiens Primates Activin ACTIVIN famplex_relations INHBA 3624
Homo sapiens Primates Activin ACTIVIN famplex_relations INHBB 3625
Homo sapiens Primates ActRIIB ACTRIIB ncbigene_synonym ACVR2B 93
Homo sapiens Primates ALK4 ALK4 ncbigene_synonym ACVR1B 91
Homo sapiens Primates BMP BMP famplex_relations BMP1 649
Homo sapiens Primates BMP BMP famplex_relations BMP2 650
Homo sapiens Primates BMP BMP famplex_relations BMP3 651
Homo sapiens Primates BMP BMP famplex_relations BMP4 652
Homo sapiens Primates BMP BMP famplex_relations BMP5 653
Homo sapiens Primates BMP BMP famplex_relations BMP6 654
Homo sapiens Primates BMP BMP famplex_relations BMP7 655
Homo sapiens Primates BMP BMP famplex_relations BMP8A 353500
Homo sapiens Primates BMP BMP famplex_relations BMP8B 656
Homo sapiens Primates BMP BMP famplex_relations BMP10 27302
Homo sapiens Primates BMP BMP famplex_relations BMP15 9210
Homo sapiens Primates BMP BMP famplex_relations GDF1 2657
Homo sapiens Primates BMP BMP famplex_relations GDF2 2658
Homo sapiens Primates BMP BMP famplex_relations GDF3 9573
Homo sapiens Primates BMP BMP famplex_relations GDF5 8200
Homo sapiens Primates BMP BMP famplex_relations GDF6 392255
Homo sapiens Primates BMP BMP famplex_relations GDF7 151449
Homo sapiens Primates Sma SMA ncbigene_synonym SMN1 6606
Homo sapiens Primates BMPRII BMPRII ncbigene_synonym BMPR2 659
Homo sapiens Primates ALK3,5 ALK3 ncbigene_synonym BMPR1A 657
Homo sapiens Primates ALK3,5,6 ALK6 ncbigene_synonym BMPR1B 658
Homo sapiens Primates mad MAD ncbigene_synonym AMPD1 270
Homo sapiens Primates mad MAD ncbigene_synonym MXD1 4084
Homo sapiens Primates AMH AMH ncbigene_symbol AMH 268
Homo sapiens Primates AMHRII AMHR2 ncbigene_symbol AMHR2 269
Homo sapiens Primates ALK2,3,6 ALK2 ncbigene_synonym ACVR1 90
Mus musculus Rodents TGFB TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGFB TGFB ncbigene_synonym Ltbp1 268977
Mus musculus Rodents TBRII TBRII ncbigene_synonym Tgfbr2 21813
Mus musculus Rodents ALK5 ALK5 ncbigene_synonym Tgfbr1 21812
Mus musculus Rodents ActRIIB ACTRIIB ncbigene_synonym Acvr2b 11481
Mus musculus Rodents ALK4 ALK4 ncbigene_synonym Acvr1b 11479
Mus musculus Rodents Sma SMA ncbigene_synonym Ighmbp2 20589
Mus musculus Rodents BMPRII BMPRII ncbigene_synonym Bmpr2 12168
Mus musculus Rodents ALK3,5 ALK3 ncbigene_synonym Bmpr1a 12166
Mus musculus Rodents ALK3,5,6 ALK6 ncbigene_synonym Bmpr1b 12167
Mus musculus Rodents mad MAD ncbigene_synonym Mxd1 17119
Mus musculus Rodents AMH AMH ncbigene_symbol Amh 11705
Mus musculus Rodents AMHRII AMHR2 ncbigene_symbol Amhr2 110542
Mus musculus Rodents ALK2,3,6 ALK2 ncbigene_synonym Acvr1 11477
Drosophila melanogaster Invertebrates Smads SMAD ncbigene_synonym Smox 31738
Drosophila melanogaster Invertebrates Smads SMAD ncbigene_synonym Mad 33529
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym mav 43804
Drosophila melanogaster Invertebrates Activin ACTIVIN ncbigene_synonym Actbeta 43826
Drosophila melanogaster Invertebrates BMP BMP ncbigene_synonym wit 44096
Drosophila melanogaster Invertebrates Sma SMA ncbigene_symbol sma 252658
Drosophila melanogaster Invertebrates mad MAD ncbigene_synonym CG2662 31254
Drosophila melanogaster Invertebrates mad MAD ncbigene_synonym Mnt 31331
Drosophila melanogaster Invertebrates mad MAD ncbigene_synonym ash2 42936
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates ActRIIB ACTRIIB ncbigene_synonym acvr2ba 30457
Danio rerio Vertebrates ALK4 ALK4 ncbigene_synonym acvr1ba 30183
Danio rerio Vertebrates ALK3,5 ALK3 ncbigene_synonym bmpr1aa 58145
Danio rerio Vertebrates mad MAD ncbigene_synonym smad5 30641
Danio rerio Vertebrates mad MAD ncbigene_synonym mxd3 394031
Danio rerio Vertebrates AMH AMH ncbigene_symbol amh 493624
Danio rerio Vertebrates ALK2,3,6 ALK2 ncbigene_synonym acvr1l 30615

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID