Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival

A working model of merlin-mediated signaling events and their potential cross-talks (the components of Drosophila Hippo signaling pathway are underlined): merlin functions upstream of the mammalian Hippo (merlin-MST1/2-LATS1/2-YAP) and JNK/p38 signaling pathways and plays an essential role in regulating the cell response to the stresses and stress-induced apoptosis as well as to proliferation/survival signals. Merlin antagonizes CD44 function and inhibits activities of RTKs and the RTK-derived growth and survival signals. CD44 function upstream of mammalian Hippo signaling pathway attenuates the stress induced activation of the hippo signaling pathway, however, enhances activities of RTKs.

Publication

Merlin, a “Magic” Linker Between the Extracellular Cues and Intracellular Signaling Pathways that Regulate Cell Motility, Proliferation, and Survival. () Ivan Stamenkovic, et al. Curr Protein Pept Sci. ;11(6):471-484. Figure: F2. All organisms Drosophila melanogaster Mus musculus Homo sapiens Rattus norvegicus Danio rerio

Disease mentions