RIG-I signalling pathway

The RIG-I signalling pathway. A) KEGG pathway diagram of the RIG-I pathway. B) A network of all InnateDB annotated molecular interactions between components of the RIG-I pathway highlights the additional level of complexity that is not conveyed in the KEGG diagram. Edges coloured red represent phosphorylation interactions; edges coloured blue represent protein-DNA interactions. C) A network of all InnateDB annotated molecular interactions between components of the RIG-I pathway and all other annotated interaction partners reveals the potential for cross-talk between RIG-I pathway components and many other molecules and pathways. Networks were constructed using InnateDB (http://www.innatedb.com/batchSearchInit.jsp) and were visualised in Cytoscape 2.6.3 using the Cerebral plugin.
RIG-I signalling pathway
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Publication

Curating the innate immunity interactome. (2010) David J Lynn, et al. BMC Syst Biol. 2010;4:117-117. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates la LA ncbigene_symbol La 35305
Drosophila melanogaster Invertebrates Va VA ncbigene_symbol Va 247258
Drosophila melanogaster Invertebrates Lace LACE ncbigene_symbol lace 34910
Drosophila melanogaster Invertebrates Fla FLA ncbigene_symbol fla 248664
Drosophila melanogaster Invertebrates MAK MAK ncbigene_synonym CG42366 34319
Drosophila melanogaster Invertebrates MAK MAK ncbigene_synonym mle 35523
Drosophila melanogaster Invertebrates TEK TEK ncbigene_synonym Fs(2)Tek 5656915
Drosophila melanogaster Invertebrates TRAF TRAF ncbigene_synonym Traf6 31746
Drosophila melanogaster Invertebrates TRAF TRAF ncbigene_synonym Traf4 33638
Drosophila melanogaster Invertebrates TRA TRA ncbigene_symbol tra 39849
Drosophila melanogaster Invertebrates TRA TRA ncbigene_synonym byn 39349
Drosophila melanogaster Invertebrates en EN ncbigene_symbol en 36240
Drosophila melanogaster Invertebrates CASP CASP ncbigene_symbol casp 36769
Drosophila melanogaster Invertebrates ATO ATO ncbigene_symbol ato 40975
Drosophila melanogaster Invertebrates De DE ncbigene_symbol de 248301
Drosophila melanogaster Invertebrates ATG12 ATG12 ncbigene_symbol Atg12 39383
Drosophila melanogaster Invertebrates TN TN ncbigene_symbol tn 37190
Drosophila melanogaster Invertebrates DAR DAR ncbigene_synonym AstA-R2 43393
Drosophila melanogaster Invertebrates RALA RALA ncbigene_symbol Rala 31332
Drosophila melanogaster Invertebrates RELA RELA ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates MAF MAF ncbigene_synonym maf-S 37336
Drosophila melanogaster Invertebrates MAF MAF ncbigene_synonym Maf1 3354925
Drosophila melanogaster Invertebrates HAT HAT ncbigene_symbol hat 47804
Drosophila melanogaster Invertebrates HAT HAT ncbigene_synonym Elp3 33649
Drosophila melanogaster Invertebrates HAT HAT ncbigene_synonym CG1894 43378
Drosophila melanogaster Invertebrates HAT HAT ncbigene_synonym chm 43928
Drosophila melanogaster Invertebrates gen GEN ncbigene_symbol Gen 38594
Homo sapiens Primates MITA MITA ncbigene_synonym STING1 340061
Homo sapiens Primates MAK MAK ncbigene_symbol MAK 4117
Homo sapiens Primates MAK MAK ncbigene_synonym ALPK3 57538
Homo sapiens Primates TH TH ncbigene_symbol TH 7054
Homo sapiens Primates TEK TEK ncbigene_symbol TEK 7010
Homo sapiens Primates TRAF TRAF famplex_relations TRAF1 7185
Homo sapiens Primates TRAF TRAF famplex_relations TRAF2 7186
Homo sapiens Primates TRAF TRAF famplex_relations TRAF3 7187
Homo sapiens Primates TRAF TRAF famplex_relations TRAF4 9618
Homo sapiens Primates TRAF TRAF famplex_relations TRAF5 7188
Homo sapiens Primates TRAF TRAF famplex_relations TRAF6 7189
Homo sapiens Primates TRAF TRAF famplex_relations TRAF7 84231
Homo sapiens Primates MAVS MAVS ncbigene_symbol MAVS 57506
Homo sapiens Primates TRA TRA ncbigene_symbol TRA 6955
Homo sapiens Primates TRA TRA ncbigene_synonym THRA 7067
Homo sapiens Primates TRA TRA ncbigene_synonym TRAC 28755
Homo sapiens Primates CASP CASP ncbigene_synonym CUX1 1523
Homo sapiens Primates CASP CASP ncbigene_synonym CYTIP 9595
Homo sapiens Primates CASP CASP ncbigene_synonym CRTAP 10491
Homo sapiens Primates ATG12 ATG12 ncbigene_symbol ATG12 9140
Homo sapiens Primates TN TN famplex_relations TNC 3371
Homo sapiens Primates TN TN famplex_relations TNN 63923
Homo sapiens Primates TN TN famplex_relations TNR 7143
Homo sapiens Primates TN TN famplex_relations TNXB 7148
Homo sapiens Primates TRAD TRAD ncbigene_synonym RAD51D 5892
Homo sapiens Primates TRAD TRAD ncbigene_synonym KALRN 8997
Homo sapiens Primates DAR DAR ncbigene_synonym ADRA1D 146
Homo sapiens Primates DAR DAR ncbigene_synonym ATP2A2 488
Homo sapiens Primates TRIS TRIS ncbigene_synonym PRDM10 56980
Homo sapiens Primates RALA RALA ncbigene_symbol RALA 5898
Homo sapiens Primates RELA RELA ncbigene_symbol RELA 5970
Homo sapiens Primates MAF MAF ncbigene_symbol MAF 4094
Homo sapiens Primates MAF MAF famplex_relations MAFA 389692
Homo sapiens Primates MAF MAF famplex_relations MAFB 9935
Homo sapiens Primates MAF MAF famplex_relations MAFF 23764
Homo sapiens Primates MAF MAF famplex_relations MAFG 4097
Homo sapiens Primates MAF MAF famplex_relations MAFK 7975
Homo sapiens Primates HAT HAT ncbigene_synonym TMPRSS11D 9407
Homo sapiens Primates gen GEN ncbigene_synonym GEN1 348654

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID