GRK2 interactome involved in the modulation of cell cycle progression

GRK2 interactome involved in the modulation of cell cycle progression. GRK2 is linked to diverse regulatory networks acting at specific stages of the cell cycle. In response to both extrinsic and intrinsic cues, GRK2 protein plays a critical role in driving cell progression through G1/S and G2/M transitions in a kinase-dependent and independent manner. GRK2 is part of an intrinsic pathway that ensures timely progression of cell cycle at G2/M by means of its functional interaction with CDK2/cyclinA and Pin1 (). Such pathway is disrupted upon DNA damage, when GRK2 appears to turn into a pro-arresting factor that promotes increased cell survival and to dampen p53-dependent responses by mechanisms that remain to be established (dotted lines/question mark). On the other hand, GRK2 contributes to the Hedgehog/Smoothened-triggered control of cell proliferation by promoting Smo activity and relieving the Patched-dependent inhibition of cyclin B (). CDK, cyclin-dependent kinase; GRK, G protein-coupled receptor kinase.

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The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets. (2010) Petronila Penela, et al. Br J Pharmacol. 2010 Jun;160(4):821-832. Figure: F3. All organisms Homo sapiens Danio rerio

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