The highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer
Schematic illustration of the highly simplified PI3K/Akt and MAP kinase pathways in thyroid cancer. Shown are the major elements in the two pathways. RTK, activated by growth factors, RET/PTC, and Ras can be coupled to both pathways. The remaining components regulate their respective pathways as described in the text. PTEN is a negative regulator of the PI3K/Akt pathway signaling. PI3K, phosphatidylinositol-3 kinase; RTK, receptor tyrosine kinase.
Publication
Genetic Alterations in the Phosphatidylinositol-3 Kinase/Akt Pathway in Thyroid Cancer. (2010) Mingzhao Xing. Thyroid. 2010 Jul;20(7):697-706. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | RET | RET | ncbigene_symbol | Ret | 43875 |
| Drosophila melanogaster | Invertebrates | RET | RET | ncbigene_synonym | reticulated | 44319 |
| Drosophila melanogaster | Invertebrates | RET | RET | ncbigene_synonym | reti | 252522 |
| Drosophila melanogaster | Invertebrates | RET | RET | ncbigene_synonym | rets | 252556 |
| Drosophila melanogaster | Invertebrates | RTK | RTK | ncbigene_synonym | Tie | 38559 |
| Drosophila melanogaster | Invertebrates | RTK | RTK | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | RTK | RTK | ncbigene_synonym | InR | 42549 |
| Drosophila melanogaster | Invertebrates | PTEN | PTEN | ncbigene_symbol | Pten | 43991 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
| Drosophila melanogaster | Invertebrates | Akt | AKT | ncbigene_symbol | Akt | 41957 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Dsor1 | 31872 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Mtk | 36708 |
| Drosophila melanogaster | Invertebrates | MTOR | MTOR | ncbigene_symbol | Mtor | 36264 |
| Drosophila melanogaster | Invertebrates | MTOR | MTOR | ncbigene_synonym | Tor | 47396 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | Erk7 | 31877 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | rl | 3354888 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Acam | 44913 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | ANGPT1 | 284 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | ANGPT2 | 285 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | ANGPT4 | 51378 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | AREG | 374 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | BDNF | 627 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | CSF1 | 1435 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EFNA1 | 1942 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EFNA2 | 1943 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EFNA3 | 1944 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EFNA4 | 1945 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EFNA5 | 1946 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EGF | 1950 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | EREG | 2069 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF1 | 2246 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF10 | 2255 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF16 | 8823 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF17 | 8822 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF18 | 8817 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF19 | 9965 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF2 | 2247 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF20 | 26281 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF21 | 26291 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF22 | 27006 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF23 | 8074 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF3 | 2248 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF4 | 2249 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF5 | 2250 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF6 | 2251 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF7 | 2252 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF8 | 2253 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FGF9 | 2254 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | FLT3LG | 2323 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | HGF | 3082 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | IGF1 | 3479 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | IGF2 | 3481 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | INS | 3630 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | KITLG | 4254 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | NGF | 4803 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | NTF3 | 4908 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | NTF4 | 4909 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | PDGFA | 5154 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | PDGFB | 5155 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | PDGFC | 56034 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | PDGFD | 80310 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | PGF | 5228 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | TGFA | 7039 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | VEGFA | 7422 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | VEGFB | 7423 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | VEGFC | 7424 |
| Homo sapiens | Primates | GrowthFactor | GROWTHFACTOR | famplex_relations | VEGFD | 2277 |
| Homo sapiens | Primates | TPC | TPC | ncbigene_synonym | CCDC6 | 8030 |
| Homo sapiens | Primates | TPC | TPC | ncbigene_synonym | SLC25A19 | 60386 |
| Homo sapiens | Primates | RET | RET | ncbigene_symbol | RET | 5979 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | BRAF | BRAF | ncbigene_symbol | BRAF | 673 |
| Homo sapiens | Primates | Akt | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | Akt | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | Akt | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
| Homo sapiens | Primates | MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA | |||
| Lung cancer | NA |