Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation

Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation. PTH stimulates T cells to secrete Wnt10b, a Wnt ligand required to activate Wnt signaling in SCs and OBs. In the presence of T cell produced Wnt10b, stimulation of osteoblastic cells by PTH result in the activation of the Wnt signaling pathway. This event leads to increased commitment of mesenchimal stem cells to the osteoblastic lineage, increased osteoblast proliferation and differentiation, and decreased osteoblast apoptosis.
Schematic representation of the role of T cells in the mechanism by which intermittent PTH treatment stimulates bone formation
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

T CELLS: CRITICAL BONE REGULATORS IN HEALTH AND DISEASE. () Roberto Pacifici. Bone. ;47(3):461-471. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PTH PTH ncbigene_symbol PTH 5741
Homo sapiens Primates PTH PTH ncbigene_synonym PTRH2 51651
Homo sapiens Primates Wnt10b WNT10B ncbigene_symbol WNT10B 7480
Homo sapiens Primates LRP4,5,6 LRP4 ncbigene_symbol LRP4 4038
Homo sapiens Primates LRP4,5,6 LRP4 ncbigene_synonym CORIN 10699
Homo sapiens Primates LRP4,5,6 LRP6 ncbigene_symbol LRP6 4040
Homo sapiens Primates LRP4,5,6 LRP5 ncbigene_symbol LRP5 4041

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID