Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease

(a) PI3K pathway regulates trafficking and PSD-95 to a synapse and cAMP regulates formation of synaptic PSD-95-TrkB complex.(b) BDNF-TrkB signaling activates MAPK/Erk, increasese cAMP and activate CREB-regulated gene transcription.(c) BDNF-TrkB signaling regulates protein translation through both MAPK/Erk and PI3K-Akt-mTOR pathways. PI3K-Akt also regulates protein trafficking in ER and Golgi.(d) A diagram showing BDNF-TrkB signaling regulates multiple molecular events through three pathways in parallel.
Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease
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Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease. () Akira Yoshii, et al. Dev Neurobiol. ;70(5):304-322. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PSD-95 PSD-95 ncbigene_synonym dlg1 32083
Drosophila melanogaster Invertebrates NMDAR NMDAR ncbigene_synonym Nmdar2 31107
Drosophila melanogaster Invertebrates NMDAR NMDAR ncbigene_synonym Nmdar1 40665
Drosophila melanogaster Invertebrates PLCY PLCG ncbigene_synonym sl 32601
Drosophila melanogaster Invertebrates AC AC ncbigene_symbol ac 30981
Drosophila melanogaster Invertebrates MAPK/Erk MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK/Erk MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK/Erk MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates MAPK/Erk ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebB 32817
Drosophila melanogaster Invertebrates CREB CREB ncbigene_synonym CrebA 39682
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates (BDNF,CAMKII, CAMKII ncbigene_symbol CaMKII 43828
Drosophila melanogaster Invertebrates Arc,Homer,etc.) ARC ncbigene_synonym Arc1 36595
Drosophila melanogaster Invertebrates Arc,Homer,etc.) ARC ncbigene_synonym Dark 36914
Drosophila melanogaster Invertebrates Arc,Homer,etc.) ARC ncbigene_synonym NA 43852
Drosophila melanogaster Invertebrates Arc,Homer,etc.) HOMER ncbigene_symbol homer 33944
Homo sapiens Primates BDNF BDNF ncbigene_symbol BDNF 627
Homo sapiens Primates BDNF BDNF ncbigene_synonym BDNF-AS 497258
Homo sapiens Primates PSD-95 PSD95 ncbigene_synonym DLG4 1742
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN1 2902
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2A 2903
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2B 2904
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2C 2905
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN2D 2906
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN3A 116443
Homo sapiens Primates NMDAR GRIN famplex_relations GRIN3B 116444
Homo sapiens Primates TrkB- TRKB ncbigene_synonym NTRK2 4915
Homo sapiens Primates PLCY PLCG famplex_relations PLCG1 5335
Homo sapiens Primates PLCY PLCG famplex_relations PLCG2 5336
Homo sapiens Primates AC ADCY famplex_relations ADCY1 107
Homo sapiens Primates AC ADCY famplex_relations ADCY2 108
Homo sapiens Primates AC ADCY famplex_relations ADCY3 109
Homo sapiens Primates AC ADCY famplex_relations ADCY4 196883
Homo sapiens Primates AC ADCY famplex_relations ADCY5 111
Homo sapiens Primates AC ADCY famplex_relations ADCY6 112
Homo sapiens Primates AC ADCY famplex_relations ADCY7 113
Homo sapiens Primates AC ADCY famplex_relations ADCY8 114
Homo sapiens Primates AC ADCY famplex_relations ADCY9 115
Homo sapiens Primates AC ADCY famplex_relations ADCY10 55811
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK/Erk MAPK famplex_relations MAPK10 5602
Homo sapiens Primates MAPK/Erk ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates CREB CREB ncbigene_synonym CREB1 1385
Homo sapiens Primates CREB CREB famplex_relations CREB3 10488
Homo sapiens Primates CREB CREB famplex_relations CREB5 9586
Homo sapiens Primates CREB CREB famplex_relations CREB3L1 90993
Homo sapiens Primates CREB CREB famplex_relations CREB3L2 64764
Homo sapiens Primates CREB CREB famplex_relations CREB3L3 84699
Homo sapiens Primates CREB CREB famplex_relations CREB3L4 148327
Homo sapiens Primates CREB CREB famplex_relations CREM 1390
Homo sapiens Primates CREB CREB famplex_relations ATF1 466
Homo sapiens Primates CREB CREB famplex_relations ATF2 1386
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates (BDNF,CAMKII, CAMKII ncbigene_synonym CAMK2G 818
Homo sapiens Primates Arc,Homer,etc.) ARC ncbigene_symbol ARC 23237
Homo sapiens Primates Arc,Homer,etc.) ARC ncbigene_synonym NOL3 8996
Homo sapiens Primates Arc,Homer,etc.) HOMER ncbigene_synonym HOMER1 9456
Homo sapiens Primates Arc,Homer,etc.) HOMER famplex_relations HOMER2 9455
Homo sapiens Primates Arc,Homer,etc.) HOMER famplex_relations HOMER3 9454

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID