STAT3 signaling pathway

STAT3 signaling pathway. Multiple cytokines, including Il-6, IL-10, IL-21, IL-22, and IL-23 activate STAT3 phosphorylation. Dimerized STAT3 enters the nucleus to affect transcription of various genes. STAT3 can also dimerize with other STATs. Normal STAT3 signaling leads to the upregulation and down regulation of the cytokines shown in the right lower corner. IL-10 and SOCS (suppressors of cytokine signaling) can downregulate STAT3 activity.
STAT3 signaling pathway
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Publication

Clinical Manifestations, Etiology, and Pathogenesis of the Hyper IgE Syndromes. () Alexandra F. Freeman, et al. Pediatr Res. ;65(5 Pt 2):32R-37R. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Danio rerio Vertebrates receptor RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates receptor RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates STAT3 STAT3 ncbigene_symbol stat3 30767
Danio rerio Vertebrates STAT5 STAT5 ncbigene_synonym stat5a 369197
Danio rerio Vertebrates socs3 SOCS3 ncbigene_synonym socs3a 335409
Danio rerio Vertebrates IL-10 IL10 ncbigene_symbol il10 553957
Danio rerio Vertebrates IFNY IFNG ncbigene_synonym ifng1 405790
Danio rerio Vertebrates IL-6 IL6 ncbigene_symbol il6 100885851
Danio rerio Vertebrates TNFA TNFA ncbigene_symbol tnfa 405785
Danio rerio Vertebrates TNFA TNFA ncbigene_synonym tnfb 554167
Homo sapiens Primates Jak JAK famplex_relations JAK1 3716
Homo sapiens Primates Jak JAK famplex_relations JAK2 3717
Homo sapiens Primates Jak JAK famplex_relations JAK3 3718
Homo sapiens Primates Jak JAK famplex_relations TYK2 7297
Homo sapiens Primates STAT3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates STAT5 STAT5 ncbigene_synonym STAT5A 6776
Homo sapiens Primates STAT5 STAT5 ncbigene_synonym STAT5B 6777
Homo sapiens Primates socs3 SOCS3 ncbigene_symbol SOCS3 9021
Homo sapiens Primates MCP-1 MCP-1 ncbigene_synonym CCL2 6347
Homo sapiens Primates IL-10 IL-10 ncbigene_synonym IL10 3586
Homo sapiens Primates IFNY IFNG ncbigene_symbol IFNG 3458
Homo sapiens Primates IL-12 IL12 famplex_relations IL12A 3592
Homo sapiens Primates IL-12 IL12 famplex_relations IL12B 3593
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043
Homo sapiens Primates TNFA TNFA ncbigene_synonym TNF 7124

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Crohns disease NA