Signaling pathway of the KRAS protein

Signaling pathway of the KRAS protein. Following EGF binding to its receptor and activation of tyrosine kinases, the KRAS protein becomes activated by binding to GTP, transducing the activation signal to the nucleus by MAPKs and PI3K/AKT-mediated cascades. Specifically, the active state of the KRAS protein is facilitated by binding to the Grb2 protein, which interacts with the SH3 domains of the SOS protein, a member of the nucleotide exchange factor family. In the GTP state, KRAS is able to activate downstream proteins and to regulate cell transformation.
Signaling pathway of the KRAS protein
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Publication

Clinical Relevance of KRAS in Human Cancers. (2010) Sylwia Jančík, et al. J Biomed Biotechnol. 2010;2010:150960. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents EGFR EGFR ncbigene_symbol Egfr 13649
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents Grb2 GRB2 ncbigene_symbol Grb2 14784
Mus musculus Rodents Shc SHC ncbigene_synonym Shc1 20416
Mus musculus Rodents Raf RAF ncbigene_synonym Zhx2 387609
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents MEK MEK ncbigene_synonym Mdk 17242
Mus musculus Rodents MEK1/2 MEK1 ncbigene_synonym Map2k1 26395
Mus musculus Rodents MEK1/2 MEK2 ncbigene_synonym Map2k2 26396
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents ERK1/2 ERK1 ncbigene_synonym Mapk3 26417
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates SOS SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates SOS SOS famplex_relations SOS1 6654
Homo sapiens Primates SOS SOS famplex_relations SOS2 6655
Homo sapiens Primates Grb2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates Shc SHC ncbigene_synonym SHC1 6464
Homo sapiens Primates Shc SHC famplex_relations SHC2 25759
Homo sapiens Primates Shc SHC famplex_relations SHC3 53358
Homo sapiens Primates Shc SHC famplex_relations SHC4 399694
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Rattus norvegicus Rodents EGFR EGFR ncbigene_symbol Egfr 24329
Rattus norvegicus Rodents Grb2 GRB2 ncbigene_symbol Grb2 81504
Rattus norvegicus Rodents GTP GTP ncbigene_synonym Pck1 362282
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents MEK1/2 MEK1 ncbigene_synonym Map2k1 170851
Rattus norvegicus Rodents AKT AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents ERK ERK ncbigene_synonym Ephb1 24338
Rattus norvegicus Rodents ERK1/2 ERK1 ncbigene_synonym Mapk3 50689
Rattus norvegicus Rodents ERK1/2 ERK2 ncbigene_synonym Mapk1 116590
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Gallus gallus Vertebrates EGFR EGFR ncbigene_symbol EGFR 396494
Gallus gallus Vertebrates Grb2 GRB2 ncbigene_symbol GRB2 386572
Gallus gallus Vertebrates Shc SHC ncbigene_synonym SHC1 395934
Gallus gallus Vertebrates PTEN PTEN ncbigene_symbol PTEN 423675
Gallus gallus Vertebrates MEK1/2 MEK2 ncbigene_synonym MAP2K2 396349
Gallus gallus Vertebrates MTOR MTOR ncbigene_symbol MTOR 419455
Drosophila melanogaster Invertebrates EGFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates SOS SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Grb2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates Shc SHC ncbigene_symbol Shc 44052
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA