Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

Hsp70 is thought to promote survival and block apoptosis through interactions with multiple steps in the pathway. For some substrates, Hsp70’s role appears to be stabilization of the substrate, while it appears to mediate the degradation of other substrates. The regulatory mechanisms that govern these activities are not known. See the main text and for references.
Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
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Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target. () Christopher G. Evans, et al. J Med Chem. ;53(12):4585-4602. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents Fas FAS ncbigene_symbol Fas 14102
Mus musculus Rodents Fas FAS ncbigene_synonym Fasn 14104
Mus musculus Rodents TNF TNF ncbigene_symbol Tnf 21926
Mus musculus Rodents TNFR TNFR ncbigene_synonym Tnfrsf1a 21937
Mus musculus Rodents Bid BID ncbigene_symbol Bid 12122
Mus musculus Rodents Casp. CASP ncbigene_synonym Crtap 56693
Mus musculus Rodents Casp.8 CASP8 ncbigene_symbol Casp8 12370
Mus musculus Rodents Hsp70 HSP70 ncbigene_synonym Hspa1b 15511
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Nr2c2 22026
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 26409
Mus musculus Rodents NIK NIK ncbigene_synonym Map4k4 26921
Mus musculus Rodents NIK NIK ncbigene_synonym Map3k14 53859
Mus musculus Rodents Apaf-1 APAF-1 ncbigene_synonym Apaf1 11783
Mus musculus Rodents Casp.9 CASP9 ncbigene_symbol Casp9 12371
Mus musculus Rodents AIF AIF ncbigene_synonym Aifm1 26926
Mus musculus Rodents Casp.3 CASP3 ncbigene_symbol Casp3 12367
Mus musculus Rodents NF-kB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents Traf2 TRAF2 ncbigene_symbol Traf2 22030
Mus musculus Rodents FADD FADD ncbigene_symbol Fadd 14082
Mus musculus Rodents RIP RIP ncbigene_symbol Rip 110628
Mus musculus Rodents RIP RIP ncbigene_synonym Agfg1 15463
Mus musculus Rodents RIP RIP ncbigene_synonym Ptpn13 19249
Mus musculus Rodents RIP RIP ncbigene_synonym Ripk1 19766
Mus musculus Rodents RIP RIP ncbigene_synonym Rpain 69723
Mus musculus Rodents (Daxx DAXX ncbigene_symbol Daxx 13163
Rattus norvegicus Rodents Fas FAS ncbigene_symbol Fas 246097
Rattus norvegicus Rodents TNF TNF ncbigene_symbol Tnf 24835
Rattus norvegicus Rodents Bid BID ncbigene_symbol Bid 64625
Rattus norvegicus Rodents Casp.8 CASP8 ncbigene_symbol Casp8 64044
Rattus norvegicus Rodents Hsp70 HSP70 ncbigene_synonym Hspa4 266759
Rattus norvegicus Rodents Hsp70 HSP70 ncbigene_synonym Hspa1b 108348108
Rattus norvegicus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 313121
Rattus norvegicus Rodents Apaf-1 APAF1 ncbigene_symbol Apaf1 78963
Rattus norvegicus Rodents Casp.9 CASP9 ncbigene_symbol Casp9 58918
Rattus norvegicus Rodents AIF AIF ncbigene_synonym Aifm1 83533
Rattus norvegicus Rodents Casp.3 CASP3 ncbigene_symbol Casp3 25402
Rattus norvegicus Rodents NF-kB NF-KB ncbigene_synonym Nfkb1 81736
Rattus norvegicus Rodents Traf2 TRAF2 ncbigene_symbol Traf2 311786
Rattus norvegicus Rodents FADD FADD ncbigene_symbol Fadd 266610
Rattus norvegicus Rodents (Daxx DAXX ncbigene_symbol Daxx 140926
Bos taurus Mammals Fas FAS ncbigene_symbol FAS 282488
Bos taurus Mammals TNF TNF ncbigene_symbol TNF 280943
Bos taurus Mammals Bid BID ncbigene_symbol BID 510373
Bos taurus Mammals Casp.8 CASP8 ncbigene_symbol CASP8 507481
Bos taurus Mammals Hsp70 HSP70 ncbigene_synonym HSPA1A 282254
Bos taurus Mammals Apaf-1 APAF1 ncbigene_symbol APAF1 537782
Bos taurus Mammals Casp.9 CASP9 ncbigene_symbol CASP9 100140945
Bos taurus Mammals AIF AIF ncbigene_synonym AIF1 280989
Bos taurus Mammals Casp.3 CASP3 ncbigene_symbol CASP3 408016
Bos taurus Mammals Traf2 TRAF2 ncbigene_symbol TRAF2 512355
Bos taurus Mammals FADD FADD ncbigene_symbol FADD 493720
Bos taurus Mammals (Daxx DAXX ncbigene_symbol DAXX 504336
Homo sapiens Primates Fas FAS ncbigene_symbol FAS 355
Homo sapiens Primates Fas FAS ncbigene_synonym FASN 2194
Homo sapiens Primates TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates TNFR TNFR ncbigene_synonym TNFRSF1A 7132
Homo sapiens Primates Bid BID ncbigene_symbol BID 637
Homo sapiens Primates Casp. CASP ncbigene_synonym CUX1 1523
Homo sapiens Primates Casp. CASP ncbigene_synonym CYTIP 9595
Homo sapiens Primates Casp. CASP ncbigene_synonym CRTAP 10491
Homo sapiens Primates Casp.8 CASP8 ncbigene_symbol CASP8 841
Homo sapiens Primates Hsp70 HSP70 ncbigene_synonym HSPA1A 3303
Homo sapiens Primates Hsp70 HSP70 ncbigene_synonym HSPA4 3308
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates NIK NIK ncbigene_synonym MAP3K14 9020
Homo sapiens Primates NIK NIK ncbigene_synonym MAP4K4 9448
Homo sapiens Primates Apaf-1 APAF-1 ncbigene_synonym APAF1 317
Homo sapiens Primates Casp.9 CASP9 ncbigene_symbol CASP9 842
Homo sapiens Primates AIF AIF ncbigene_synonym AIFM1 9131
Homo sapiens Primates Casp.3 CASP3 ncbigene_symbol CASP3 836
Homo sapiens Primates NF-kB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates Traf2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates Traf2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates RIP RIP ncbigene_synonym AGFG1 3267
Homo sapiens Primates RIP RIP ncbigene_synonym RIPK1 8737
Homo sapiens Primates RIP RIP ncbigene_synonym DCAF1 9730
Homo sapiens Primates RIP RIP ncbigene_synonym RPAIN 84268
Homo sapiens Primates (Daxx DAXX ncbigene_symbol DAXX 1616
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym Fas2 31364
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN1 33524
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym Fas3 35097
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym fand 36514
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym tei 36521
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym rg 44531
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN2 117361
Drosophila melanogaster Invertebrates Fas FAS ncbigene_synonym FASN3 3355111
Drosophila melanogaster Invertebrates TNF TNF ncbigene_synonym egr 36054
Drosophila melanogaster Invertebrates TNFR TNFR ncbigene_synonym wgn 32849
Drosophila melanogaster Invertebrates Casp. CASP ncbigene_symbol casp 36769
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsc70-3 32133
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsc70-1 39542
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsc70-4 41840
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Ab 44920
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Ba 44921
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Aa 48581
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Bb 48582
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Bc 48583
Drosophila melanogaster Invertebrates Hsp70 HSP70 ncbigene_synonym Hsp70Bbb 50022
Drosophila melanogaster Invertebrates TAK1 TAK1 ncbigene_symbol Tak1 39659
Drosophila melanogaster Invertebrates NIK NIK ncbigene_symbol Ni-K 252004
Drosophila melanogaster Invertebrates NIK NIK ncbigene_synonym msn 44030
Drosophila melanogaster Invertebrates Apaf-1 APAF-1 ncbigene_synonym Dark 36914
Drosophila melanogaster Invertebrates AIF AIF ncbigene_symbol AIF 33390
Drosophila melanogaster Invertebrates Casp.3 CASP3 ncbigene_synonym Decay 42008
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-kB NF-KB ncbigene_synonym Rel 41087
Drosophila melanogaster Invertebrates Traf2 TRAF2 ncbigene_synonym Traf6 31746
Drosophila melanogaster Invertebrates FADD FADD ncbigene_symbol Fadd 42594
Drosophila melanogaster Invertebrates RIP RIP ncbigene_symbol rip 44045
Drosophila melanogaster Invertebrates RIP RIP ncbigene_synonym ripp 246815
Drosophila melanogaster Invertebrates (Daxx DAXX ncbigene_symbol Daxx 33906
Danio rerio Vertebrates Fas FAS ncbigene_symbol fas 768248
Danio rerio Vertebrates TNF TNF ncbigene_synonym tnfrsfa 114461
Danio rerio Vertebrates TNF TNF ncbigene_synonym tnfb 554167
Danio rerio Vertebrates Bid BID ncbigene_synonym bida 559425
Danio rerio Vertebrates Casp.8 CASP8 ncbigene_symbol casp8 58022
Danio rerio Vertebrates Hsp70 HSP70 ncbigene_synonym hsp70.3 30671
Danio rerio Vertebrates Hsp70 HSP70 ncbigene_synonym hspa8l 387608
Danio rerio Vertebrates Hsp70 HSP70 ncbigene_synonym hsp70l 560210
Danio rerio Vertebrates Hsp70 HSP70 ncbigene_synonym hsp70.1 100126123
Danio rerio Vertebrates Apaf-1 APAF-1 ncbigene_synonym apaf1 58131
Danio rerio Vertebrates Casp.9 CASP9 ncbigene_symbol casp9 492763
Danio rerio Vertebrates AIF AIF ncbigene_synonym aifm1 373125
Danio rerio Vertebrates Casp.3 CASP3 ncbigene_synonym casp3a 140621
Danio rerio Vertebrates FADD FADD ncbigene_symbol fadd 562317
Danio rerio Vertebrates (Daxx DAXX ncbigene_symbol daxx 561006

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID