Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization

Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization. Gain of function mutations in PI3K or loss of function mutations in PTEN result in recruitment of Akt and PDK1/2 to the membrane where Akt is phosphorylated. Active Akt can phosphorylate MDM2 increasing cytoplasmic to nuclear shuttling and effectively dampening the p53 pathway. The effectiveness of the p53 pathway can be augmented by increasing p53 stability (nutlin-3), or targeting PI3K (LY294002), PDK1 (UNC-01) or Akt simultaneously.
Crosstalk between the PI3K/AKT pathway and p53 activation: Potential stratagies for combined radiosensitization
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Publication

Radiosensitization of Prostate Cancer by Priming the Wild-type p53-Dependent Cellular Senescence Pathway. () Brian D. Lehmann, et al. Cancer Biol Ther. ;6(8):1165-1170. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PDK PDK famplex_relations PDK1 5163
Homo sapiens Primates PDK PDK famplex_relations PDK2 5164
Homo sapiens Primates PDK PDK famplex_relations PDK3 5165
Homo sapiens Primates PDK PDK famplex_relations PDK4 5166
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates P130 P130 ncbigene_synonym RBL2 5934
Homo sapiens Primates P130 P130 ncbigene_synonym NOLC1 9221
Homo sapiens Primates P130 P130 ncbigene_synonym RAB3GAP1 22930
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates p53 P53 ncbigene_synonym TP53 7157
Homo sapiens Primates p53 P53 famplex_relations TP63 8626
Homo sapiens Primates p53 P53 famplex_relations TP73 7161
Homo sapiens Primates P14ARF P14ARF ncbigene_synonym CDKN2A 1029
Homo sapiens Primates p58 P58 ncbigene_synonym CDK11B 984
Homo sapiens Primates p58 P58 ncbigene_synonym PDIA3 2923
Homo sapiens Primates p58 P58 ncbigene_synonym KIR2DL3 3804
Homo sapiens Primates p58 P58 ncbigene_synonym PKM 5315
Homo sapiens Primates p58 P58 ncbigene_synonym PRIM2 5558
Homo sapiens Primates p58 P58 ncbigene_synonym DNAJC3 5611
Homo sapiens Primates p58 P58 ncbigene_synonym PSMD3 5709
Homo sapiens Primates p58 P58 ncbigene_synonym RAD23B 5887
Homo sapiens Primates p58 P58 ncbigene_synonym IFIT5 24138
Homo sapiens Primates p58 P58 ncbigene_synonym H3P20 100289141
Homo sapiens Primates Chk2 CHK2 ncbigene_synonym CHEK2 11200
Homo sapiens Primates Chk1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates p21 P21 ncbigene_synonym CDKN1A 1026
Homo sapiens Primates p21 P21 ncbigene_synonym TCEAL1 9338
Homo sapiens Primates p21 P21 ncbigene_synonym NSG1 27065
Homo sapiens Primates p21 P21 ncbigene_synonym H3P16 644914
Homo sapiens Primates GADD45 GADD45 ncbigene_synonym GADD45A 1647
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Drosophila melanogaster Invertebrates PDK PDK ncbigene_symbol Pdk 35970
Drosophila melanogaster Invertebrates PDK PDK ncbigene_synonym Pdk1 38017
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates eo EO ncbigene_symbol Eo 32423
Drosophila melanogaster Invertebrates p53 P53 ncbigene_symbol p53 2768677
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p53 P53 ncbigene_synonym hth 41273
Drosophila melanogaster Invertebrates p58 P58 ncbigene_synonym Rpn3 35176
Drosophila melanogaster Invertebrates p58 P58 ncbigene_synonym Cdk8 39157
Drosophila melanogaster Invertebrates Chk2 CHK2 ncbigene_synonym lok 35288
Drosophila melanogaster Invertebrates Chk1 CHK1 ncbigene_synonym grp 34993
Drosophila melanogaster Invertebrates p21 P21 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates GADD45 GADD45 ncbigene_symbol Gadd45 35646
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym mei-41 32608
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym RYa-R 43253
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839

Chemical mentions

Word Match MeSH Name ChEBI
LY294002 NA mesh:C085911

Disease mentions

Word Match MeSH Name DOID
Cancer NA