Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells

Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells. The PI3 kinase pathway is shown on the right and the Ras/Map kinase pathway on the left. Following EGFR activation, a series of sequential phosphorylation events result in cell proliferation and survival through increased transcription and translation of key proteins while inhibiting pro-apoptotic pathways. Agents that target key points in the pathway that are discussed in the text are shown in parentheses at their respective sites of action.Abbreviation: EGFR, epidermal growth factor receptor; mTOR, mammalian target of rapamycin; mTORI, mTOR inhibitor; TKI, tyrosine kinase inhibitor; FTI, farnesyl transferase inhibitor; HDACI, histone deacetylase inhibitor; PTEN, phosphatase and tensin homologue deleted on chromosome 10; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-triphosphate.
Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells

Publication

Targeted therapy in the treatment of malignant gliomas. (2009) Rimas V Lukas, et al. Onco Targets Ther. 2009;2:115-133. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents EĞFR EGFR ncbigene_symbol Egfr 13649
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents p70s6k P70S6K ncbigene_synonym Rps6kb1 72508
Homo sapiens Primates EĞFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates p70s6k P70S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates p70s6k P70S6K famplex_relations RPS6KB2 6199
Rattus norvegicus Rodents EĞFR EGFR ncbigene_symbol Egfr 24329
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Drosophila melanogaster Invertebrates EĞFR EGFR ncbigene_symbol Egfr 37455
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates p70s6k P70S6K ncbigene_synonym S6k 38654
Drosophila melanogaster Invertebrates on ON ncbigene_symbol On 252296

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Lung cancer NA