Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells
Simplified diagram of the two major pathways affected by EGFR-mediated signaling in malignant glioma cells. The PI3 kinase pathway is shown on the right and the Ras/Map kinase pathway on the left. Following EGFR activation, a series of sequential phosphorylation events result in cell proliferation and survival through increased transcription and translation of key proteins while inhibiting pro-apoptotic pathways. Agents that target key points in the pathway that are discussed in the text are shown in parentheses at their respective sites of action.Abbreviation: EGFR, epidermal growth factor receptor; mTOR, mammalian target of rapamycin; mTORI, mTOR inhibitor; TKI, tyrosine kinase inhibitor; FTI, farnesyl transferase inhibitor; HDACI, histone deacetylase inhibitor; PTEN, phosphatase and tensin homologue deleted on chromosome 10; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-triphosphate.

Publication
Targeted therapy in the treatment of malignant gliomas. (2009) Rimas V Lukas, et al. Onco Targets Ther. 2009;2:115-133. Figure: F1.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
---|---|---|---|---|---|---|
Mus musculus | Rodents | EĞFR | EGFR | ncbigene_symbol | Egfr | 13649 |
Mus musculus | Rodents | PI3K | PI3K | ncbigene_synonym | Pik3r1 | 18708 |
Mus musculus | Rodents | Ras | RAS | ncbigene_symbol | ras | 19412 |
Mus musculus | Rodents | Ras | RAS | ncbigene_synonym | Hras | 15461 |
Mus musculus | Rodents | Ras | RAS | ncbigene_synonym | Kras | 16653 |
Mus musculus | Rodents | Ras | RAS | ncbigene_synonym | Rem1 | 19700 |
Mus musculus | Rodents | PTEN | PTEN | ncbigene_symbol | Pten | 19211 |
Mus musculus | Rodents | Akt | AKT | ncbigene_synonym | Akt1 | 11651 |
Mus musculus | Rodents | MTOR | MTOR | ncbigene_symbol | Mtor | 56717 |
Mus musculus | Rodents | p70s6k | P70S6K | ncbigene_synonym | Rps6kb1 | 72508 |
Homo sapiens | Primates | EĞFR | EGFR | ncbigene_symbol | EGFR | 1956 |
Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
Homo sapiens | Primates | Akt | AKT | ncbigene_synonym | AKT1 | 207 |
Homo sapiens | Primates | Akt | AKT | famplex_relations | AKT2 | 208 |
Homo sapiens | Primates | Akt | AKT | famplex_relations | AKT3 | 10000 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK1 | 5594 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK3 | 5595 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK11 | 5600 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK12 | 6300 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK13 | 5603 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK14 | 1432 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK8 | 5599 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK9 | 5601 |
Homo sapiens | Primates | MAPK | MAPK | famplex_relations | MAPK10 | 5602 |
Homo sapiens | Primates | MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
Homo sapiens | Primates | p70s6k | P70S6K | ncbigene_synonym | RPS6KB1 | 6198 |
Homo sapiens | Primates | p70s6k | P70S6K | famplex_relations | RPS6KB2 | 6199 |
Rattus norvegicus | Rodents | EĞFR | EGFR | ncbigene_symbol | Egfr | 24329 |
Rattus norvegicus | Rodents | PI3K | PI3K | ncbigene_synonym | Pik3cg | 298947 |
Rattus norvegicus | Rodents | PTEN | PTEN | ncbigene_symbol | Pten | 50557 |
Rattus norvegicus | Rodents | Akt | AKT | ncbigene_synonym | Akt1 | 24185 |
Rattus norvegicus | Rodents | MTOR | MTOR | ncbigene_symbol | Mtor | 56718 |
Drosophila melanogaster | Invertebrates | EĞFR | EGFR | ncbigene_symbol | Egfr | 37455 |
Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_symbol | ras | 43873 |
Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras64B | 38494 |
Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras85D | 41140 |
Drosophila melanogaster | Invertebrates | PTEN | PTEN | ncbigene_symbol | Pten | 43991 |
Drosophila melanogaster | Invertebrates | Akt | AKT | ncbigene_symbol | Akt | 41957 |
Drosophila melanogaster | Invertebrates | MAPK | MAPK | ncbigene_synonym | MKP-4 | 32963 |
Drosophila melanogaster | Invertebrates | MAPK | MAPK | ncbigene_synonym | p38b | 34780 |
Drosophila melanogaster | Invertebrates | MAPK | MAPK | ncbigene_synonym | rl | 3354888 |
Drosophila melanogaster | Invertebrates | MTOR | MTOR | ncbigene_symbol | Mtor | 36264 |
Drosophila melanogaster | Invertebrates | MTOR | MTOR | ncbigene_synonym | Tor | 47396 |
Drosophila melanogaster | Invertebrates | p70s6k | P70S6K | ncbigene_synonym | S6k | 38654 |
Drosophila melanogaster | Invertebrates | on | ON | ncbigene_symbol | On | 252296 |
Word | Match | MeSH | Name | ChEBI |
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Disease mentions
Word | Match | MeSH | Name | DOID |
---|---|---|---|---|
Cancer | NA | |||
Lung cancer | NA |