PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL)

PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL). PI3K-Akt and Ras/Raf/MAPK pathways are common routes that control key cellular responses. The large amount of cross-talk between these pathways is often responsible for treatment resistance.
PI3K-Akt-mTOR pathway and cross-talk with other signaling cascades: (Ras/Raf/MAPK and BCR-ABL)
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Publication

Multiple roles and therapeutic implications of Akt signaling in cancer. (2009) Emiliano Calvo, et al. Onco Targets Ther. 2009;2:135-150. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents VEGF VEGF ncbigene_synonym Vegfa 83785
Rattus norvegicus Rodents EGF/TNFA TNFA ncbigene_synonym Tnf 24835
Rattus norvegicus Rodents EGF/TNFA EGF ncbigene_symbol Egf 25313
Rattus norvegicus Rodents IGF-1 IGF1 ncbigene_symbol Igf1 24482
Rattus norvegicus Rodents P13K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 24855
Rattus norvegicus Rodents TSC1/TSC2 TSC1 ncbigene_symbol Tsc1 60445
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents ERK ERK ncbigene_synonym Ephb1 24338
Rattus norvegicus Rodents elF-4E EIF4E ncbigene_symbol Eif4e 117045
Canis lupus familiaris Mammals VEGF VEGF ncbigene_synonym VEGFA 403802
Canis lupus familiaris Mammals EGF/TNFA TNFA ncbigene_synonym TNF 403922
Canis lupus familiaris Mammals EGF/TNFA EGF ncbigene_symbol EGF 403657
Canis lupus familiaris Mammals IGF-1 IGF1 ncbigene_symbol IGF1 610255
Canis lupus familiaris Mammals PTEN PTEN ncbigene_symbol PTEN 403832
Canis lupus familiaris Mammals TSC2 TSC2 ncbigene_symbol TSC2 479883
Canis lupus familiaris Mammals TSC1/TSC2 TSC1 ncbigene_symbol TSC1 480688
Canis lupus familiaris Mammals MTOR MTOR ncbigene_symbol MTOR 478232
Canis lupus familiaris Mammals elF-4E EIF4E ncbigene_symbol EIF4E 487870
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates EGF/TNFA TNFA ncbigene_synonym TNF 7124
Homo sapiens Primates EGF/TNFA EGF ncbigene_symbol EGF 1950
Homo sapiens Primates PDGF PDGF famplex_relations PDGFA 5154
Homo sapiens Primates PDGF PDGF famplex_relations PDGFB 5155
Homo sapiens Primates PDGF PDGF famplex_relations PDGFC 56034
Homo sapiens Primates PDGF PDGF famplex_relations PDGFD 80310
Homo sapiens Primates IGF-1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates P13K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates P13K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates P13K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates P13K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates P13K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates P13K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates P13K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates Bcr-Abl BCR-ABL ncbigene_synonym ABL1 25
Homo sapiens Primates (MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates (MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates (MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates TSC1/TSC2 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/TSC2 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates elF-4E EIF-4E ncbigene_synonym EIF4E 1977
Mus musculus Rodents VEGF VEGF ncbigene_synonym Vegfa 22339
Mus musculus Rodents EGF/TNFA TNFA ncbigene_synonym Tnf 21926
Mus musculus Rodents EGF/TNFA EGF ncbigene_symbol Egf 13645
Mus musculus Rodents IGF-1 IGF-1 ncbigene_synonym Igf1 16000
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents P13K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents Raf RAF ncbigene_synonym Zhx2 387609
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents (MEK MEK ncbigene_synonym Mdk 17242
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents TSC1/TSC2 TSC1 ncbigene_symbol Tsc1 64930
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents 4E-BP1 4E-BP1 ncbigene_synonym Eif4ebp1 13685
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents elF-4E EIF-4E ncbigene_synonym Eif4e 13684
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf1 32876
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf2 33994
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvf3 33995
Drosophila melanogaster Invertebrates VEGF VEGF ncbigene_synonym Pvr 34127
Drosophila melanogaster Invertebrates EGF/TNFA TNFA ncbigene_synonym egr 36054
Drosophila melanogaster Invertebrates EGF/TNFA EGF ncbigene_synonym Egfr 37455
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Tie 38559
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym InR 42549
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates P13K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates MAPKKK MAPKKK ncbigene_synonym wnd 40143
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MAPKK MAPKK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MAPKK MAPKK ncbigene_synonym hep 32256
Drosophila melanogaster Invertebrates (MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates TSC1/TSC2 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates 4E-BP1 4E-BP1 ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates elF-4E EIF-4E ncbigene_synonym eIF4E1 45525

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA