Schematic representation of the intracellular cholesterol transport pathway

Schematic representation of the intracellular cholesterol transport pathway. Extracellular cholesterol enters the cell via the LDL receptor and endocytosis. Transport from the endosomal system to the endoplasmic reticulum (ER) occurs via transport proteins such as Niemann-Pick Type C (NPC) protein. Once at the ER, excess cholesterol is converted to cholesterol ester by ACAT. If intracellular cholesterol levels drop, the N-terminus of the Sterol Regulatory Element Binding Protein (SREBP) is released and enters the cell nucleus, resulting in transcription of mRNA to increase cholesterol production and increase receptors for extracellular cholesterol.
Schematic representation of the intracellular cholesterol transport pathway
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Publication

INTRACELLULAR CHOLESTEROL HOMEOSTASIS AND AMYLOID PRECURSOR PROTEIN PROCESSING. () Mark Burns, et al. Biochim Biophys Acta. ;1801(8):853-859. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates LDL LDL ncbigene_synonym modSP 42032
Drosophila melanogaster Invertebrates early EARLY ncbigene_synonym lds 45894
Drosophila melanogaster Invertebrates NPC1 NPC1 ncbigene_synonym Npc1a 34358
Drosophila melanogaster Invertebrates NPC2 NPC2 ncbigene_synonym Npc2a 33374
Drosophila melanogaster Invertebrates NPC2 NPC2 ncbigene_synonym Npc2b 41710
Drosophila melanogaster Invertebrates CoA COA ncbigene_symbol Coa 248135
Drosophila melanogaster Invertebrates HMG HMG ncbigene_synonym Hmgcr 42803
Drosophila melanogaster Invertebrates HMG HMG ncbigene_synonym Dsp1 117294
Drosophila melanogaster Invertebrates ACAT ACAT ncbigene_symbol alpha-Cat 40517
Drosophila melanogaster Invertebrates ACAT ACAT ncbigene_synonym Acat2 38147
Drosophila melanogaster Invertebrates ACAT ACAT ncbigene_synonym CG8112 41033
Drosophila melanogaster Invertebrates Insig/SREBP/Scap SCAP ncbigene_symbol SCAP 35529
Drosophila melanogaster Invertebrates Insig/SREBP/Scap SCAP ncbigene_synonym bmm 39611
Drosophila melanogaster Invertebrates Insig/SREBP/Scap SREBP ncbigene_symbol SREBP 40155
Arabidopsis thaliana Plants and Fungi NPC1 NPC1 ncbigene_symbol NPC1 837234
Arabidopsis thaliana Plants and Fungi late LATE ncbigene_symbol LATE 834947
Arabidopsis thaliana Plants and Fungi NPC2 NPC2 ncbigene_symbol NPC2 817228
Arabidopsis thaliana Plants and Fungi HMG HMG ncbigene_symbol HMG 822505
Homo sapiens Primates NPC1 NPC1 ncbigene_symbol NPC1 4864
Homo sapiens Primates NPC1 NPC1 ncbigene_synonym NPCA1 257641
Homo sapiens Primates NPC2 NPC2 ncbigene_symbol NPC2 10577
Homo sapiens Primates ACAT ACAT ncbigene_synonym ACAT1 38
Homo sapiens Primates ACAT ACAT ncbigene_synonym CES1 1066
Homo sapiens Primates ACAT ACAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates Insig/SREBP/Scap SCAP ncbigene_symbol SCAP 22937
Homo sapiens Primates Insig/SREBP/Scap SCAP ncbigene_synonym SH2D2A 9047

Chemical mentions

Word Match MeSH Name ChEBI
cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
ester ester mesh:D004952 Esters chebi:35701

Disease mentions

Word Match MeSH Name DOID