With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging

The diagram represents the genetic interactions in the TOR signaling network that execute lifespan extension in yeast, worms, flies and mice. The diagram summarizes the lifespan data for genes in the TOR signaling pathway or those that demonstrate a genetic interaction with mutants in the TOR pathway. The shaded area refers to components of the TOR pathway that show conserved effects on lifespan extension in different species. See main text for details.
With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging
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With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging. () Pankaj Kapahi, et al. Cell Metab. ;11(6):453-465. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Tsc2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates mTor MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates mTor MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates Tor TOR ncbigene_symbol tor 35717
Drosophila melanogaster Invertebrates Tor TOR ncbigene_synonym Egfr 37455
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates SaK SAK ncbigene_symbol SAK 40384
Drosophila melanogaster Invertebrates SGK SGK ncbigene_synonym Tpi 43582
Drosophila melanogaster Invertebrates PHD PHD ncbigene_symbol ph-d 44889
Drosophila melanogaster Invertebrates PHD PHD ncbigene_synonym Hph 40633
Drosophila melanogaster Invertebrates Rin1 RIN1 ncbigene_synonym spri 31987
Drosophila melanogaster Invertebrates AMP AMP ncbigene_synonym Amph 36383
Drosophila melanogaster Invertebrates Ire-1 IRE-1 ncbigene_synonym Ire1 42358
Mus musculus Rodents Tsc2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents Rheb RHEB ncbigene_symbol Rheb 19744
Mus musculus Rodents Raptor RAPTOR ncbigene_synonym Rptor 74370
Mus musculus Rodents mTor MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents Tor TOR ncbigene_symbol tor 21977
Mus musculus Rodents Tor TOR ncbigene_synonym Rorc 19885
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents SEK SEK ncbigene_synonym Epha4 13838
Mus musculus Rodents SaK SAK ncbigene_synonym Plk4 20873
Mus musculus Rodents SGK SGK ncbigene_synonym Sgk1 20393
Mus musculus Rodents Rin1 RIN1 ncbigene_symbol Rin1 225870
Mus musculus Rodents AMPH AMPH ncbigene_symbol Amph 218038
Mus musculus Rodents Ire-1 IRE1 ncbigene_synonym Ern2 26918
Mus musculus Rodents PNC1 PNC1 ncbigene_synonym Slc25a33 70556
Homo sapiens Primates Tsc2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates mTor MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates Tor TOR ncbigene_synonym RORC 6097
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates SEK SEK ncbigene_synonym EPHA4 2043
Homo sapiens Primates SaK SAK ncbigene_synonym PLK4 10733
Homo sapiens Primates SGK SGK ncbigene_synonym SGK1 6446
Homo sapiens Primates PHD PHD ncbigene_synonym PDC 5132
Homo sapiens Primates Rin1 RIN1 ncbigene_symbol RIN1 9610
Homo sapiens Primates AMP AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates AMPH AMPH ncbigene_symbol AMPH 273
Homo sapiens Primates Bec-1 BEC-1 ncbigene_synonym TRARG1 286753
Homo sapiens Primates Ire-1 IRE1 ncbigene_synonym ERN1 2081
Homo sapiens Primates PNC1 PNC1 ncbigene_synonym SLC25A33 84275
Rattus norvegicus Rodents Tsc2 TSC2 ncbigene_symbol Tsc2 24855
Rattus norvegicus Rodents Rheb RHEB ncbigene_symbol Rheb 26954
Rattus norvegicus Rodents mTor MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents SGK SGK ncbigene_synonym Sgk1 29517
Rattus norvegicus Rodents Rin1 RIN1 ncbigene_symbol Rin1 207119
Rattus norvegicus Rodents AMP AMP ncbigene_synonym Tmprss5 266681
Rattus norvegicus Rodents AMPH AMPH ncbigene_symbol Amph 60668
Rattus norvegicus Rodents Bec-1 BEC1 ncbigene_synonym Kcnh3 27150
Caenorhabditis elegans Invertebrates Rin1 RIN1 ncbigene_symbol rin-1 3565509
Caenorhabditis elegans Invertebrates Bec-1 BEC-1 ncbigene_symbol bec-1 177345
Caenorhabditis elegans Invertebrates Ire-1 IRE-1 ncbigene_symbol ire-1 174305
Caenorhabditis elegans Invertebrates PNC1 PNC1 ncbigene_symbol pnc-1 176833
Schizosaccharomyces pombe Plants and Fungi Tsc2 TSC2 ncbigene_symbol tsc2 2543339
Schizosaccharomyces pombe Plants and Fungi Ire-1 IRE1 ncbigene_symbol ire1 2542776
Schizosaccharomyces pombe Plants and Fungi PNC1 PNC1 ncbigene_symbol pnc1 2540906
Saccharomyces cerevisiae S288C Plants and Fungi Tsc2 TSC2 ncbigene_synonym LCB1 855342
Saccharomyces cerevisiae S288C Plants and Fungi Rin1 RIN1 ncbigene_synonym ERI1 856008
Saccharomyces cerevisiae S288C Plants and Fungi MSN2 MSN2 ncbigene_symbol MSN2 855053
Saccharomyces cerevisiae S288C Plants and Fungi GCN4 GCN4 ncbigene_symbol GCN4 856709
Saccharomyces cerevisiae S288C Plants and Fungi Ire-1 IRE1 ncbigene_symbol IRE1 856478
Saccharomyces cerevisiae S288C Plants and Fungi PNC1 PNC1 ncbigene_symbol PNC1 852846
Danio rerio Vertebrates Tsc2 TSC2 ncbigene_symbol tsc2 567524
Danio rerio Vertebrates Rheb RHEB ncbigene_symbol rheb 393702
Danio rerio Vertebrates Rheb RHEB ncbigene_synonym rhebl1 767781
Danio rerio Vertebrates mTor MTOR ncbigene_symbol mtor 324254
Danio rerio Vertebrates SGK SGK ncbigene_synonym sgk1 324140
Danio rerio Vertebrates AMPH AMPH ncbigene_symbol amph 393804

Chemical mentions

Word Match MeSH Name ChEBI
Glycerol Glycerol mesh:D005990 glycerol chebi:17754
AMP Metformin Metformin mesh:D008687 metformin chebi:6801
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID