Diagram of PDGF-D cross-talks with other pathways

Diagram of PDGF-D cross-talks with other pathways. ERK: extracellular signal-regulated kinase; IL-1β: proinflammatory cytokine interleukin-1β; MAPK: mitogen-activated proteinkinase; MMPs: matrix metalloproteinases; mTOR: mammalian target of rapamycin; NF-κB: nuclear factor-κB; PI3K: phosphatidylinositol 3-kinase; ROS: reactive oxygen species; uPA: urokinase-type plasminogen activator; VEGF: vascular endothelial growth factor. EMT: epithelial-mesenchymal transition.
Diagram of PDGF-D cross-talks with other pathways
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Publication

Emerging roles of PDGF-D signaling pathway in tumor development and progression. () Zhiwei Wang, et al. Biochim Biophys Acta. ;1806(1):122-130. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents plasminogen PLG ncbigene_symbol Plg 85253
Rattus norvegicus Rodents IL-18 IL-18 ncbigene_synonym Il18 29197
Rattus norvegicus Rodents PDGF-D PDGFD ncbigene_symbol Pdgfd 66018
Rattus norvegicus Rodents E-cadherin CDH1 ncbigene_symbol Cdh1 83502
Rattus norvegicus Rodents E-cadherin CDH1 ncbigene_synonym Fzr1 314642
Rattus norvegicus Rodents ERK ERK ncbigene_synonym Ephb1 24338
Rattus norvegicus Rodents Snail,ZEB SNAI1 ncbigene_symbol Snai1 116490
Rattus norvegicus Rodents VEGF VEGF ncbigene_synonym Vegfa 83785
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents PI3K/Akt PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents Notch NOTCH ncbigene_synonym Notch1 25496
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 81736
Rattus norvegicus Rodents EMT EMT ncbigene_synonym Slc22a3 29504
Homo sapiens Primates plasminogen PLG ncbigene_symbol PLG 5340
Homo sapiens Primates IL-18 IL-18 ncbigene_synonym IL18 3606
Homo sapiens Primates PDGF-D PDGFD ncbigene_symbol PDGFD 80310
Homo sapiens Primates PDGFR PDGFR ncbigene_synonym PDGFRB 5159
Homo sapiens Primates PDGFR PDGFR famplex_relations PDGFRA 5156
Homo sapiens Primates E-cadherin CDH1 ncbigene_symbol CDH1 999
Homo sapiens Primates E-cadherin CDH1 ncbigene_synonym FZR1 51343
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates (MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates Snail,ZEB SNAIL ncbigene_synonym SNAI1 6615
Homo sapiens Primates VEGF VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF VEGF famplex_relations PGF 5228
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PI3K/Akt PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K/Akt PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K/Akt PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K/Akt PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K/Akt PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH1 4851
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH2 4853
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH3 4854
Homo sapiens Primates Notch NOTCH famplex_relations NOTCH4 4855
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581
Mus musculus Rodents plasminogen PLG ncbigene_symbol Plg 18815
Mus musculus Rodents IL-18 IL-18 ncbigene_synonym Il18 16173
Mus musculus Rodents PDGF-D PDGFD ncbigene_symbol Pdgfd 71785
Mus musculus Rodents PDGFR PDGFR ncbigene_synonym Pdgfrb 18596
Mus musculus Rodents E-cadherin CDH1 ncbigene_symbol Cdh1 12550
Mus musculus Rodents E-cadherin CDH1 ncbigene_synonym Fzr1 56371
Mus musculus Rodents ERK ERK ncbigene_synonym Ephb2 13844
Mus musculus Rodents ERK ERK ncbigene_synonym Mapk1 26413
Mus musculus Rodents MMPSSnail,ZEB ZEB ncbigene_synonym Zeb1 21417
Mus musculus Rodents Snail,ZEB SNAIL ncbigene_synonym Snai1 20613
Mus musculus Rodents VEGF VEGF ncbigene_synonym Vegfa 22339
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PI3K/Akt PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Mus musculus Rodents EMT EMT ncbigene_synonym Itk 16428
Mus musculus Rodents EMT EMT ncbigene_synonym Slc22a3 20519
Danio rerio Vertebrates plasminogen PLG ncbigene_symbol plg 322691
Danio rerio Vertebrates PDGF-D PDGFD ncbigene_symbol pdgfd 100535718
Danio rerio Vertebrates E-cadherin E-CADHERIN ncbigene_synonym cdh1 114424
Danio rerio Vertebrates E-cadherin E-CADHERIN ncbigene_synonym si:busm1-180o5.1 368516
Danio rerio Vertebrates E-cadherin E-CADHERIN ncbigene_synonym si:busm1-180o5.2 368517
Danio rerio Vertebrates Snail,ZEB SNAI1 ncbigene_synonym snai1a 30273
Danio rerio Vertebrates VEGF VEGF ncbigene_synonym vegfaa 30682
Danio rerio Vertebrates MTOR MTOR ncbigene_symbol mtor 324254

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA