Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5)

Pathway analysis of disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5). Green indicates a down-regulation in the gene and red indicates an induction in gene expression. Each connection has two or more references supporting the association or relationship. Note that dieldrin-mediated genes are located in a variety of cellular compartments and are predominantly induced after treatment.
Disease associations in the hypothalamus (genes regulated at p<0.001; fold change > ±1.5)
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Publication

Effects of acute dieldrin exposure on neurotransmitters and global gene transcription in largemouth bass (Micropterus salmoides) hypothalamus. () Christopher J. Martyniuk, et al. Neurotoxicology. ;31(4):356-366. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates INS INS ncbigene_symbol INS 3630
Homo sapiens Primates JAG1 JAG1 ncbigene_symbol JAG1 182
Homo sapiens Primates C1S C1S ncbigene_symbol C1S 716
Homo sapiens Primates GFER GFER ncbigene_symbol GFER 2671
Homo sapiens Primates SLC4A1 SLC4A1 ncbigene_symbol SLC4A1 6521
Homo sapiens Primates PC PC ncbigene_symbol PC 5091
Homo sapiens Primates SLC12A3 SLC12A3 ncbigene_symbol SLC12A3 6559
Homo sapiens Primates VIL1 VIL1 ncbigene_symbol VIL1 7429
Homo sapiens Primates GALK1 GALK1 ncbigene_symbol GALK1 2584
Homo sapiens Primates Mud MUD ncbigene_synonym AP5M1 55745
Homo sapiens Primates PNMT PNMT ncbigene_symbol PNMT 5409
Homo sapiens Primates PNMT PNMT ncbigene_synonym PEMT 10400
Homo sapiens Primates MYLK MYLK ncbigene_symbol MYLK 4638
Homo sapiens Primates med28 MED28 ncbigene_symbol MED28 80306
Homo sapiens Primates NARG1 NARG1 ncbigene_synonym NAA15 80155
Homo sapiens Primates BIRC2 BIRC2 ncbigene_symbol BIRC2 329
Homo sapiens Primates C1QBP C1QBP ncbigene_symbol C1QBP 708
Homo sapiens Primates FES FES ncbigene_symbol FES 2242
Homo sapiens Primates CREB1 CREB1 ncbigene_symbol CREB1 1385
Homo sapiens Primates TOPBP1 TOPBP1 ncbigene_symbol TOPBP1 11073
Homo sapiens Primates CCNB1 CCNB1 ncbigene_symbol CCNB1 891
Homo sapiens Primates MCM2 MCM2 ncbigene_symbol MCM2 4171
Homo sapiens Primates MCM2 MCM2 ncbigene_synonym MCM7 4176
Homo sapiens Primates DCK DCK ncbigene_symbol DCK 1633
Homo sapiens Primates PELP1 PELP1 ncbigene_symbol PELP1 27043
Homo sapiens Primates PRC1 PRC1 ncbigene_symbol PRC1 9055
Homo sapiens Primates PRC1 PRC1 famplex_relations BMI1 648
Homo sapiens Primates PRC1 PRC1 famplex_relations CBX2 84733
Homo sapiens Primates PRC1 PRC1 famplex_relations CBX4 8535
Homo sapiens Primates PRC1 PRC1 famplex_relations CBX8 57332
Homo sapiens Primates PRC1 PRC1 famplex_relations PCGF2 7703
Homo sapiens Primates PRC1 PRC1 famplex_relations PHC1 1911
Homo sapiens Primates PRC1 PRC1 famplex_relations PHC2 1912
Homo sapiens Primates PRC1 PRC1 famplex_relations PHC3 80012
Homo sapiens Primates PRC1 PRC1 famplex_relations PHF1 5252
Homo sapiens Primates PRC1 PRC1 famplex_relations RING1 6015
Homo sapiens Primates PRC1 PRC1 famplex_relations RNF2 6045
Homo sapiens Primates PRC1 PRC1 famplex_relations SCMH1 22955
Homo sapiens Primates PRC1 PRC1 famplex_relations YY1 7528
Homo sapiens Primates PRC1 PRC1 famplex_relations ZNF134 7693
Homo sapiens Primates AND-1 AND-1 ncbigene_synonym WDHD1 11169
Homo sapiens Primates ESR2 ESR2 ncbigene_symbol ESR2 2100
Micropterus salmoides Vertebrates INS INS ncbigene_symbol ins 119894945
Micropterus salmoides Vertebrates GFER GFER ncbigene_symbol gfer 119885734
Micropterus salmoides Vertebrates SLC12A3 SLC12A3 ncbigene_symbol slc12a3 119894298
Micropterus salmoides Vertebrates GALK1 GALK1 ncbigene_symbol galk1 119916123
Micropterus salmoides Vertebrates med28 MED28 ncbigene_symbol med28 119898815
Micropterus salmoides Vertebrates BIRC2 BIRC2 ncbigene_symbol birc2 119884738
Micropterus salmoides Vertebrates C1QBP C1QBP ncbigene_symbol c1qbp 119896217
Micropterus salmoides Vertebrates FES FES ncbigene_symbol fes 119890424
Micropterus salmoides Vertebrates TOPBP1 TOPBP1 ncbigene_symbol topbp1 119911854
Micropterus salmoides Vertebrates CCNB1 CCNB1 ncbigene_symbol ccnb1 119914274
Micropterus salmoides Vertebrates MCM2 MCM2 ncbigene_symbol mcm2 119886261
Micropterus salmoides Vertebrates DCK DCK ncbigene_symbol dck 119914098
Micropterus salmoides Vertebrates PELP1 PELP1 ncbigene_symbol pelp1 119911315
Danio rerio Vertebrates INS INS ncbigene_symbol ins 30262
Danio rerio Vertebrates JAG1 JAG1 ncbigene_synonym jag1a 140421
Danio rerio Vertebrates C1S C1S ncbigene_synonym c1s.1 793529
Danio rerio Vertebrates GFER GFER ncbigene_symbol gfer 560433
Danio rerio Vertebrates SLC4A1 SLC4A1 ncbigene_synonym slc4a1a 84703
Danio rerio Vertebrates SLC12A3 SLC12A3 ncbigene_symbol slc12a3 565439
Danio rerio Vertebrates VIL1 VIL1 ncbigene_symbol vil1 393207
Danio rerio Vertebrates GALK1 GALK1 ncbigene_symbol galk1 449829
Danio rerio Vertebrates MYLK MYLK ncbigene_synonym mylka 569510
Danio rerio Vertebrates med28 MED28 ncbigene_symbol med28 493610
Danio rerio Vertebrates receptors RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates receptors RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates BIRC2 BIRC2 ncbigene_symbol birc2 373107
Danio rerio Vertebrates Kinases KINASE ncbigene_synonym pak2a 266749
Danio rerio Vertebrates Kinases KINASE ncbigene_synonym itpka 368717
Danio rerio Vertebrates C1QBP C1QBP ncbigene_symbol c1qbp 334619
Danio rerio Vertebrates FES FES ncbigene_symbol fes 566739
Danio rerio Vertebrates CREB1 CREB1 ncbigene_synonym creb1a 573207
Danio rerio Vertebrates TOPBP1 TOPBP1 ncbigene_symbol topbp1 407679
Danio rerio Vertebrates CCNB1 CCNB1 ncbigene_symbol ccnb1 58025
Danio rerio Vertebrates MCM2 MCM2 ncbigene_symbol mcm2 192338
Danio rerio Vertebrates DCK DCK ncbigene_symbol dck 474325
Danio rerio Vertebrates DCK DCK ncbigene_synonym zgc:110540 541538
Danio rerio Vertebrates PELP1 PELP1 ncbigene_symbol pelp1 100003680
Danio rerio Vertebrates PRC1 PRC1 ncbigene_synonym prc1a 259194
Danio rerio Vertebrates AND-1 AND-1 ncbigene_synonym wdhd1 436999

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID