Pathway of de novo synthesis of saturated and monounsaturated fatty acids and regulation of lipogenic genes by transcription factors (LXR, SREBP-1c and ChREBP)
Pathway of de novo synthesis of saturated and monounsaturated fatty acids and regulation of lipogenic genes by transcription factors (LXR, SREBP-1c and ChREBP). NADPH is required for fatty acid synthesis and three chemical reactions yield NADPH (inset). PGC-1β has been shown to coactivate LXR and SREBP-1c, as discussed in the text. ACL, ATP-citrate lyase; ACC, acetyl-CoA carboxylase; FAS, fatty acid synthase; ELOVL6, elongation of long-chain fatty acids family member 6 (elongase 6); SCD, stearoyl-CoA desaturase; LXR, liver X receptor; SREBP-1c, sterol regulatory element-binding protein 1c; ChREBP, carbohydrate response element binding protein; ME, malic enzyme; G6PD, glucose 6-phosphate dehydrogenase; PGD, Phosphogluconate dehydrogenase. Color version of figure is available online.
Publication
Genetic control of de novo lipogenesis: role in diet-induced obesity. () Maggie S. Strable, et al. Crit Rev Biochem Mol Biol. ;45(3):199-214. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | NADPH | NADPH | ncbigene_synonym | DECR1 | 1666 |
| Homo sapiens | Primates | G6PD | G6PD | ncbigene_symbol | G6PD | 2539 |
| Homo sapiens | Primates | G6PD | G6PD | ncbigene_synonym | UBL4A | 8266 |
| Homo sapiens | Primates | PGD | PGD | ncbigene_symbol | PGD | 5226 |
| Homo sapiens | Primates | PGD | PGD | ncbigene_synonym | PHGDH | 26227 |
| Homo sapiens | Primates | CHREBP | CHREBP | ncbigene_synonym | MLXIPL | 51085 |
| Homo sapiens | Primates | LXR | LXR | famplex_relations | NR1H2 | 7376 |
| Homo sapiens | Primates | LXR | LXR | famplex_relations | NR1H3 | 10062 |
| Homo sapiens | Primates | FAS | FAS | ncbigene_symbol | FAS | 355 |
| Homo sapiens | Primates | FAS | FAS | ncbigene_synonym | FASN | 2194 |
| Homo sapiens | Primates | Elovl6 | ELOVL6 | ncbigene_symbol | ELOVL6 | 79071 |
| Homo sapiens | Primates | (C16:0) | C160 | ncbigene_synonym | POLR3A | 11128 |
| Homo sapiens | Primates | SCD | SCD | ncbigene_symbol | SCD | 6319 |
| Homo sapiens | Primates | SCD | SCD | famplex_relations | SCD5 | 79966 |
| Danio rerio | Vertebrates | G6PD | G6PD | ncbigene_symbol | g6pd | 570579 |
| Danio rerio | Vertebrates | PGD | PGD | ncbigene_symbol | pgd | 406762 |
| Danio rerio | Vertebrates | CHREBP | CHREBP | ncbigene_synonym | mlxip | 798052 |
| Danio rerio | Vertebrates | FAS | FAS | ncbigene_symbol | fas | 768248 |
| Danio rerio | Vertebrates | Elovl6 | ELOVL6 | ncbigene_symbol | elovl6 | 317738 |
| Danio rerio | Vertebrates | SCD | SCD | ncbigene_symbol | scd | 386661 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Palmitoleate | NA | mesh:C008757 | ||
| 6-Phosphogluconate | NA | mesh:C008884 | ||
| Ribulose 5-phosphate | ribulose 5-phosphate | mesh:C031524 | ribulose 5-phosphate | chebi:37455 |
| 6-Phosphogluconolactone | NA | mesh:C114004 | ||
| Cholesteryl Ester | Cholesterol Esters | mesh:D002788 | cholesteryl ester | chebi:17002 |
| Fructose | Fructose | mesh:D005632 | fructose | chebi:28757 |
| Glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| Malate | Malates | mesh:D008293 | malate | chebi:25115 |
| Malonyl-CoA | Malonyl Coenzyme A | mesh:D008316 | malonyl-CoA | chebi:15531 |
| Pyruvate | NA | mesh:D011773 | ||
| Triglyceride | Triglycerides | mesh:D014280 | triglyceride | chebi:17855 |
| Glucose 6-Phosphate | NA | mesh:D019298 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|