CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2

CXCR5 activate PI3K isoforms through Gα-Src-FAK pathway or via Gβ/γ pathway leading to subsequent activation of ERK1/2. LNCaP cells express PI3Kp110α, PI3Kp110β and PI3Kp110δ, while PC3 cells express PI3Kp110α, PI3Kp110β and PI3Kp110γ. Perhaps owing to their more aggressive phenotype, PC3 cells are capable of exploiting both Gα-Src-FAK and Gβ/γ-mediated events leading to enhanced migration and invasion, while LNCaP cells are only able to take advantage of the Gα-Src-FAK-mediated pathway following CXCL13-CXCR5 interaction.
CXCR5 activate PI3K isoforms through GAlpha-Src-FAK pathway or via GB/G pathway leading to subsequent activation of ERK1/2
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells. (2010) Christelle P El Haibi, et al. Mol Cancer. 2010;9:85-85. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PC3 PC3 ncbigene_synonym KRT6A 3853
Homo sapiens Primates PC3 PC3 ncbigene_synonym PCSK1 5122
Homo sapiens Primates PC3 PC3 ncbigene_synonym BTG2 7832
Homo sapiens Primates PC3 PC3 ncbigene_synonym ACTR1B 10120
Homo sapiens Primates PC3 PC3 ncbigene_synonym CBX8 57332
Homo sapiens Primates CXCR5 CXCR5 ncbigene_symbol CXCR5 643
Homo sapiens Primates FAK FAK ncbigene_synonym PTK2 5747
Homo sapiens Primates SRC SRC ncbigene_symbol SRC 6714
Homo sapiens Primates SRC SRC famplex_relations FGR 2268
Homo sapiens Primates SRC SRC famplex_relations FYN 2534
Homo sapiens Primates SRC SRC famplex_relations YES1 7525
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PI3,4,5P, PI3 ncbigene_symbol PI3 5266
Homo sapiens Primates P14,5 P14 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates P14,5 P14 ncbigene_synonym S100A9 6280
Homo sapiens Primates P14,5 P14 ncbigene_synonym CDK2AP2 10263
Homo sapiens Primates P14,5 P14 ncbigene_synonym SUB1 10923
Homo sapiens Primates P14,5 P14 ncbigene_synonym RPP14 11102
Homo sapiens Primates P14,5 P14 ncbigene_synonym LAMTOR2 28956
Homo sapiens Primates P14,5 P14 ncbigene_synonym SF3B6 51639
Homo sapiens Primates P14,5 P14 ncbigene_synonym H3P8 115482693
Homo sapiens Primates P2 P2 ncbigene_synonym MPEG1 219972
Homo sapiens Primates PI4,5P2 PI4 ncbigene_synonym SERPINA4 5267
Homo sapiens Primates DOCK2 DOCK2 ncbigene_symbol DOCK2 1794
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates (p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates (p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates (p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates (p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID