Akt signaling pathway

The Akt signaling pathway. Growth factor signaling results in activation of PI3K and conversion of PIP2 to PIP3. Proteins containing a PH domain are recruited to the membrane and participate in phosphorylation reactions. PTEN, PP2A, and Rheb-GDP negatively regulate the pathway. PIP2, phosphatidylinositol (3,4)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PH, pleckstrin homology domain; HM, C-terminal hydrophobic motif; 4E-BP, inhibitory eIF4E-binding proteins; S6K, ribosomal S6 kinases; PP2A, protein phosphatase 2A.
Akt signaling pathway
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Publication

Proinflammatory Stem Cell Signaling in Cardiac Ischemia. (2009) Jeremy L. Herrmann, et al. Antioxid Redox Signal. 2009 Aug;11(8):1883-1896. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates (MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates (MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates GBL GBL ncbigene_synonym Lst8 31903
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wrd 42169
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym wdb 43312
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym mts 45959
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym tws 47877
Drosophila melanogaster Invertebrates PP2A PP2A ncbigene_synonym Pp2A-29B 2768940
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates 4E-BPs 4E-BP ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates (MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates GBL GBL ncbigene_synonym MLST8 64223
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PP2A PP2A ncbigene_synonym PTPA 5524
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA