Jak/STAT signaling pathway

The Jak/STAT signaling pathway. Signal activation occurs through binding of IL-6, CT-1, or LIF. Increased gene expression occurs after STAT is phosphorylated, dimerizes, and translocates to the nucleus. Inhibitory steps include the SOCS, SHP2, PIAS, and elongin proteins.
Jak/STAT signaling pathway
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Publication

Proinflammatory Stem Cell Signaling in Cardiac Ischemia. (2009) Jeremy L. Herrmann, et al. Antioxid Redox Signal. 2009 Aug;11(8):1883-1896. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IL-6{ IL6 ncbigene_symbol IL6 3569
Homo sapiens Primates CT-1 CT-1 ncbigene_synonym CTF1 1489
Homo sapiens Primates LIF LIF ncbigene_symbol LIF 3976
Homo sapiens Primates IL-6R IL-6R ncbigene_synonym IL6R 3570
Homo sapiens Primates gp130 GP130 ncbigene_synonym IL6ST 3572
Homo sapiens Primates gp130 GP130 ncbigene_synonym NM 4827
Homo sapiens Primates gp130 GP130 ncbigene_synonym LRPPRC 10128
Homo sapiens Primates LIFR LIFR ncbigene_symbol LIFR 3977
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT1 6772
Homo sapiens Primates STAT STAT famplex_relations STAT2 6773
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Homo sapiens Primates SHP2 SHP2 ncbigene_synonym PTPN11 5781
Homo sapiens Primates Jak JAK famplex_relations JAK1 3716
Homo sapiens Primates Jak JAK famplex_relations JAK2 3717
Homo sapiens Primates Jak JAK famplex_relations JAK3 3718
Homo sapiens Primates Jak JAK famplex_relations TYK2 7297
Homo sapiens Primates SOCS SOCS ncbigene_synonym CISH 1154
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates Proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates Proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates İNOS INOS ncbigene_synonym NOS2 4843
Homo sapiens Primates İNOS INOS ncbigene_synonym ISYNA1 51477

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID