Role of Rad9A in the G2 decatenation checkpoint

Role of Rad9A in the G2 decatenation checkpoint. Inhibition of Topo II by ICRF-193 prevents catenated chromosomes from being resolved following replication. Catenated chromosomes induce a G2 checkpoint delay, mediated by ATR. ATR acts upstream of both BRCA1 and Plk1 (not illustrated) in a pathway that results in exclusion of Cyclin B1 from the nucleus and delay in mitotic progression. Rad9A may play a role in this pathway as a substrate of ATR or through interactions with Topo-binding protein 1 (TopBP1), which also binds Topo II. ATM is also activated, as indicated by autophosphorylation at Ser1981. ATM phosphorylates Rad9A Ser272 and Chk2 Thr68 in response to catenated chromosomes. Rad9A and Chk2 both function to prevent re-replication and cut-like phenotypes, and ATM may function in a redundant manner to prevent cell cycle progression in cancer lung cells.
Role of Rad9A in the G2 decatenation checkpoint
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Publication

Rad9A Is Required for G2 Decatenation Checkpoint and to Prevent Endoreduplication in Response to Topoisomerase II Inhibition. (2010) Deborah A. Greer Card, et al. J Biol Chem. 2010 May 14;285(20):15653-15661. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates WRN WRN ncbigene_symbol WRN 7486
Homo sapiens Primates Rad9A RAD9A ncbigene_symbol RAD9A 5883
Homo sapiens Primates P68 P68 ncbigene_synonym ANXA6 309
Homo sapiens Primates P68 P68 ncbigene_synonym DDX5 1655
Homo sapiens Primates P68 P68 ncbigene_synonym KHDRBS1 10657
Homo sapiens Primates P68 P68 ncbigene_synonym POLD3 10714
Homo sapiens Primates P68 P68 ncbigene_synonym GATAD2B 57459
Homo sapiens Primates Chk2 CHK2 ncbigene_synonym CHEK2 11200
Homo sapiens Primates BRCA1 BRCA1 ncbigene_symbol BRCA1 672
Homo sapiens Primates TopBP1 TOPBP1 ncbigene_symbol TOPBP1 11073
Homo sapiens Primates B1 B1 ncbigene_synonym B3GNT2 10678
Homo sapiens Primates B1 B1 ncbigene_synonym B3GNTL1 146712
Homo sapiens Primates Cdc2 CDC2 ncbigene_synonym CDK1 983
Homo sapiens Primates Cdc2 CDC2 ncbigene_synonym POLD1 5424
Homo sapiens Primates CyclinB1 CCNB1 ncbigene_symbol CCNB1 891
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents WRN WRN ncbigene_symbol Wrn 22427
Mus musculus Rodents Rad9A RAD9A ncbigene_symbol Rad9a 19367
Mus musculus Rodents P68 P68 ncbigene_synonym Ddx5 13207
Mus musculus Rodents P68 P68 ncbigene_synonym Khdrbs1 20218
Mus musculus Rodents P68 P68 ncbigene_synonym Tkt 21881
Mus musculus Rodents P68 P68 ncbigene_synonym Pold3 67967
Mus musculus Rodents Chk2 CHK2 ncbigene_synonym Chek2 50883
Mus musculus Rodents BRCA1 BRCA1 ncbigene_symbol Brca1 12189
Mus musculus Rodents TopBP1 TOPBP1 ncbigene_symbol Topbp1 235559
Mus musculus Rodents B1 B1 ncbigene_synonym Hbb-b1 15129
Mus musculus Rodents B1 B1 ncbigene_synonym B3gnt9 97440
Mus musculus Rodents Cdc2 CDC2 ncbigene_synonym Cdk1 12534
Mus musculus Rodents Cdc2 CDC2 ncbigene_synonym Cdc2b 107833
Mus musculus Rodents CyclinB1 CCNB1 ncbigene_symbol Ccnb1 268697

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID