Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

In our previous work we demonstrated that GLP-1 or Exendin-4 increased cAMP production. Here we propose that the GLP-1 action shares key downstream components of the insulin signaling pathway, including PKCĪ¶, which has been shown to be a key factor in NAFLD.
Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
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Glucagon-like Peptide-1 Receptor (GLP-1R) is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. () Nitika Arora Gupta, et al. Hepatology. ;51(5):1584-1592. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Bos taurus Mammals GLP1-R GLP1R ncbigene_symbol GLP1R 517420
Bos taurus Mammals IRS-1/2 IRS2 ncbigene_symbol IRS2 100300012
Bos taurus Mammals IRS-1/2 IRS1 ncbigene_symbol IRS1 538598
Bos taurus Mammals PI3 PI3 ncbigene_symbol PI3 783871
Bos taurus Mammals IRS-3 IRS3 ncbigene_symbol IRS3 107131843
Bos taurus Mammals IRS-3/4 IRS4 ncbigene_symbol IRS4 514607
Bos taurus Mammals PDK1 PDK1 ncbigene_symbol PDK1 528655
Bos taurus Mammals PDK2 PDK2 ncbigene_symbol PDK2 524075
Bos taurus Mammals AKT AKT ncbigene_synonym AKT1 280991
Oryctolagus cuniculus Mammals GLP1-R GLP1R ncbigene_symbol GLP1R 100356720
Oryctolagus cuniculus Mammals IRS-1/2 IRS2 ncbigene_symbol IRS2 103349113
Oryctolagus cuniculus Mammals IRS-1/2 IRS1 ncbigene_symbol IRS1 100339981
Oryctolagus cuniculus Mammals IRS-3/4 IRS4 ncbigene_symbol IRS4 103351932
Oryctolagus cuniculus Mammals PDK1 PDK1 ncbigene_symbol PDK1 100351323
Oryctolagus cuniculus Mammals PDK2 PDK2 ncbigene_symbol PDK2 100348343
Homo sapiens Primates GLP1-R GLP1R ncbigene_symbol GLP1R 2740
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates IRS-1/2 IRS-2 ncbigene_synonym IRS2 8660
Homo sapiens Primates IRS-1 IRS1 ncbigene_symbol IRS1 3667
Homo sapiens Primates PI3 PI3 ncbigene_symbol PI3 5266
Homo sapiens Primates IRS-3/4 IRS-4 ncbigene_synonym IRS4 8471
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates PDK2 PDK2 ncbigene_symbol PDK2 5164
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates GLUT2 GLUT2 ncbigene_synonym SLC2A2 6514
Homo sapiens Primates P70 P70 ncbigene_synonym ANXA6 309
Homo sapiens Primates P70 P70 ncbigene_synonym UBASH3B 84959
Rattus norvegicus Rodents GLP1-R GLP1R ncbigene_symbol Glp1r 25051
Rattus norvegicus Rodents GPCR GPCR ncbigene_synonym Tas2r134 295589
Rattus norvegicus Rodents GPCR GPCR ncbigene_synonym Rxfp2 363866
Rattus norvegicus Rodents IRS-1/2 IRS-2 ncbigene_synonym Irs2 29376
Rattus norvegicus Rodents IRS-1 IRS1 ncbigene_symbol Irs1 25467
Rattus norvegicus Rodents PI3 PI3 ncbigene_synonym Wfdc15b 408230
Rattus norvegicus Rodents IRS-3 IRS3 ncbigene_symbol Irs3 84021
Rattus norvegicus Rodents IRS-3/4 IRS-4 ncbigene_synonym Irs4 315350
Rattus norvegicus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 116551
Rattus norvegicus Rodents PDK2 PDK2 ncbigene_symbol Pdk2 81530
Rattus norvegicus Rodents AKT AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents PKC PKC ncbigene_synonym Prkcg 24681
Rattus norvegicus Rodents GLUT2 GLUT2 ncbigene_synonym Slc2a2 25351
Mus musculus Rodents GLP1-R GLP1R ncbigene_symbol Glp1r 14652
Mus musculus Rodents GPCR GPCR ncbigene_synonym Gpbar1 227289
Mus musculus Rodents IRS-1/2 IRS-2 ncbigene_synonym Irs2 384783
Mus musculus Rodents IRS-1/2 IRS-1 ncbigene_synonym Irs1 16367
Mus musculus Rodents PI3 PI3 ncbigene_synonym Serpina1c 20702
Mus musculus Rodents IRS-3 IRS3 ncbigene_symbol Irs3 16369
Mus musculus Rodents IRS-3/4 IRS-4 ncbigene_synonym Irs4 16370
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents PDK2 PDK2 ncbigene_symbol Pdk2 18604
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents GLUT2 GLUT2 ncbigene_synonym Slc2a2 20526
Mus musculus Rodents P70 P70 ncbigene_synonym Elf1 13709
Mus musculus Rodents P70 P70 ncbigene_synonym Il2rb 16185
Mus musculus Rodents P70 P70 ncbigene_synonym Ubash3b 72828
Drosophila melanogaster Invertebrates GPCR GPCR ncbigene_synonym Oamb 43982
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates GSK-B GSKB ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym WDR79 33865
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym tral 39430
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym rump 41138
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym MED17 42175
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym SF1 43912
Drosophila melanogaster Invertebrates P70 P70 ncbigene_synonym Irbp 117419
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates Receptor RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates TCAMP TCAMP ncbigene_synonym tram1 266757
Danio rerio Vertebrates IRS-1/2 IRS2 ncbigene_synonym irs2b 572001
Danio rerio Vertebrates IRS-1/2 IRS1 ncbigene_symbol irs1 559281
Danio rerio Vertebrates Kinase KINASE ncbigene_synonym pak2a 266749
Danio rerio Vertebrates Kinase KINASE ncbigene_synonym itpka 368717
Danio rerio Vertebrates PDK1 PDK1 ncbigene_symbol pdk1 555840
Danio rerio Vertebrates PDK2 PDK2 ncbigene_synonym pdk2b 393971
Danio rerio Vertebrates GLUT2 GLUT2 ncbigene_synonym slc2a2 322493

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA