Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion

Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion. Many of the proteins involved in this signaling network are known to be O-GlcNAc modified, but the functional roles of this modification in each case remain to be established.
Cross-talk between the hexosamine biosynthesis pathway, O-GlcNAc modification of proteins, signaling events downstream of insulin action, and glucose-induced adipocytokine secretion
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Publication

Hexosamine Flux, the O-GlcNAc Modification, and the Development of Insulin Resistance in Adipocytes. () Chin Fen Teo, et al. Mol Cell Endocrinol. ;318(1-2):44-53. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents SP1 SP1 ncbigene_symbol Sp1 20683
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents GFAT GFAT ncbigene_synonym Gfpt1 14583
Mus musculus Rodents OGT OGT ncbigene_symbol Ogt 108155
Mus musculus Rodents OGA OGA ncbigene_symbol Oga 76055
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PP1 PP1 ncbigene_synonym Ppp1cc 19047
Mus musculus Rodents PP1 PP1 ncbigene_synonym Npy4r 19065
Mus musculus Rodents ÁS160 AS160 ncbigene_synonym Tbc1d4 210789
Mus musculus Rodents GSK3B GSK3B ncbigene_symbol Gsk3b 56637
Mus musculus Rodents GS GS ncbigene_symbol gs 14835
Mus musculus Rodents GS GS ncbigene_symbol Gs 109550
Mus musculus Rodents GLUT4 GLUT4 ncbigene_synonym Slc2a4 20528
Mus musculus Rodents GLUT GLUT ncbigene_synonym Slc1a3 20512
Mus musculus Rodents VAMP2 VAMP2 ncbigene_symbol Vamp2 22318
Homo sapiens Primates IRS IRS ncbigene_synonym IARS1 3376
Homo sapiens Primates IRS IRS famplex_relations IRS1 3667
Homo sapiens Primates IRS IRS famplex_relations IRS2 8660
Homo sapiens Primates IRS IRS famplex_relations IRS4 8471
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates SP1 SP1 ncbigene_symbol SP1 6667
Homo sapiens Primates SP1 SP1 ncbigene_synonym PSG1 5669
Homo sapiens Primates SP1 SP1 ncbigene_synonym DAND5 199699
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MTORC1 MTORC1 famplex_relations MTOR 2475
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates GFAT GFAT ncbigene_synonym GFPT1 2673
Homo sapiens Primates GFAT GFAT ncbigene_synonym GFPT2 9945
Homo sapiens Primates OGT OGT ncbigene_symbol OGT 8473
Homo sapiens Primates OGT OGT famplex_relations EOGT 285203
Homo sapiens Primates OGT OGT famplex_relations POMGNT1 55624
Homo sapiens Primates OGT OGT famplex_relations POMGNT2 84892
Homo sapiens Primates OGA OGA ncbigene_symbol OGA 10724
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PP1 PP1 ncbigene_synonym PPA1 5464
Homo sapiens Primates PP1 PP1 ncbigene_synonym NPY4R 5540
Homo sapiens Primates PP1 PP1 ncbigene_synonym NPY4R2 100996758
Homo sapiens Primates ÁS160 AS160 ncbigene_synonym TBC1D4 9882
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates GS GS famplex_relations GNAS 2778
Homo sapiens Primates GS GS famplex_relations GNAL 2774
Homo sapiens Primates GLUT4 GLUT4 ncbigene_synonym SLC2A4 6517
Homo sapiens Primates GLUT GLUT ncbigene_synonym SLC2A1 6513
Homo sapiens Primates VAMP2 VAMP2 ncbigene_symbol VAMP2 6844
Homo sapiens Primates -actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates -actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates -actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates -actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates -actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates -actin ACTIN famplex_relations ACTG2 72
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents SP1 SP1 ncbigene_symbol Sp1 24790
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 116551
Rattus norvegicus Rodents AMPK AMPK ncbigene_synonym Prkaa2 78975
Rattus norvegicus Rodents GFAT GFAT ncbigene_synonym Gfpt1 297417
Rattus norvegicus Rodents OGT OGT ncbigene_symbol Ogt 26295
Rattus norvegicus Rodents OGA OGA ncbigene_symbol Oga 154968
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents GSK3B GSK3B ncbigene_symbol Gsk3b 84027
Rattus norvegicus Rodents GLUT4 GLUT4 ncbigene_synonym Slc2a4 25139
Rattus norvegicus Rodents GLUT GLUT ncbigene_synonym Gls 24398
Rattus norvegicus Rodents VAMP2 VAMP2 ncbigene_symbol Vamp2 24803
Drosophila melanogaster Invertebrates IRS IRS ncbigene_synonym IRSp53 39258
Drosophila melanogaster Invertebrates IRS IRS ncbigene_synonym IleRS 45785
Drosophila melanogaster Invertebrates IRS IRS ncbigene_synonym chico 64880
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates SP1 SP1 ncbigene_symbol Sp1 31913
Drosophila melanogaster Invertebrates SP1 SP1 ncbigene_synonym grass 43273
Drosophila melanogaster Invertebrates SP1 SP1 ncbigene_synonym Spn42Dd 49808
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates GFAT GFAT ncbigene_synonym Gfat1 3354921
Drosophila melanogaster Invertebrates OGT OGT ncbigene_synonym sxc 35486
Drosophila melanogaster Invertebrates OGA OGA ncbigene_symbol Oga 42518
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym Pp1alpha-96A 42922
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym flw 44289
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym br 44505
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym Pp4-19C 45031
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym Pp1-13C 48531
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym Pp1-87B 49260
Drosophila melanogaster Invertebrates PP1 PP1 ncbigene_synonym PpD6 49780
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym Axn 43565
Drosophila melanogaster Invertebrates GSK3B GSK3B ncbigene_synonym gskt 318552
Drosophila melanogaster Invertebrates G6P G6P ncbigene_symbol G6P 33476
Drosophila melanogaster Invertebrates GS GS ncbigene_symbol gs 5656925
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Eaat1 34251
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut1 38109
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut4EF 41217
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut3 42036
Drosophila melanogaster Invertebrates VAMP2 VAMP2 ncbigene_synonym Syb 36080
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act57B 37368
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act79B 40444
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act88F 41885
Drosophila melanogaster Invertebrates -actin ACTIN ncbigene_synonym Act87E 48632
Drosophila melanogaster Invertebrates Glc GLC ncbigene_synonym GluClalpha 42350
Drosophila melanogaster Invertebrates Glc GLC ncbigene_synonym betaGlu 43746
Drosophila melanogaster Invertebrates Syntaxin SYNTAXIN ncbigene_synonym Syx1A 42854

Chemical mentions

Word Match MeSH Name ChEBI
Fatty acid Fatty Acids mesh:D005227 fatty acid chebi:35366
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659

Disease mentions

Word Match MeSH Name DOID
Diabetes mellitus NA