Overview of the sphingolipid metabolic pathway
Overview of the sphingolipid metabolic pathway. Ceramide (cer) is central to sphingolipid metabolism and can be generated via de novo biosynthesis, through the degradation of complex sphingolipids, or by the recycling of sphingosine. Degradation of ceramide leads to the formation of sphingosine and sphingosine-1-phosphate (S1P). Abbreviations: serine palmitoyltransferase (SPT), ceramide (cer), ceramide kinase (CK), sphingomyelin (SM), sphingomyelinase (SMase), sphingomyelin synthase (SM synthase), sphingosine kinase (SK), sphingosine-1-phosphate (S1P).
Publication
The Interplay Between Bioactive Sphingolipids and Steroid Hormones. () Natasha C. Lucki, et al. Steroids. ;75(6):390-399. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | De | DE | ncbigene_symbol | de | 248301 |
| Drosophila melanogaster | Invertebrates | SPT | SPT | ncbigene_symbol | Spt | 35889 |
| Drosophila melanogaster | Invertebrates | SPT | SPT | ncbigene_synonym | lace | 34910 |
| Drosophila melanogaster | Invertebrates | SPT | SPT | ncbigene_synonym | en | 36240 |
| Drosophila melanogaster | Invertebrates | SPT | SPT | ncbigene_synonym | Spt-I | 36448 |
| Drosophila melanogaster | Invertebrates | SPT | SPT | ncbigene_synonym | srp | 41944 |
| Drosophila melanogaster | Invertebrates | Cer | CER | ncbigene_symbol | cer | 37229 |
| Drosophila melanogaster | Invertebrates | CK | CK | ncbigene_symbol | ck | 34882 |
| Drosophila melanogaster | Invertebrates | SM | SM | ncbigene_symbol | sm | 37254 |
| Drosophila melanogaster | Invertebrates | Cor | COR | ncbigene_symbol | Cor | 250502 |
| Drosophila melanogaster | Invertebrates | Cor | COR | ncbigene_synonym | cort | 33937 |
| Drosophila melanogaster | Invertebrates | Cor | COR | ncbigene_synonym | cora | 37205 |
| Drosophila melanogaster | Invertebrates | Cor | COR | ncbigene_synonym | Crz | 41742 |
| Drosophila melanogaster | Invertebrates | SK | SK | ncbigene_symbol | SK | 31456 |
| Drosophila melanogaster | Invertebrates | S1P | S1P | ncbigene_symbol | S1P | 40399 |
| Homo sapiens | Primates | SPT | SPT | ncbigene_synonym | AGXT | 189 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | RBM14 | 10432 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | KANK2 | 25959 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | CACYBP | 27101 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | TP53INP1 | 94241 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | TSACC | 128229 |
| Homo sapiens | Primates | SIP | SIP | ncbigene_synonym | RBM14-RBM4 | 100526737 |
| Homo sapiens | Primates | S1P | S1P | ncbigene_synonym | MBTPS1 | 8720 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| 3-ketosphinganine | NA | mesh:C002882 | ||
| Sphinganine | NA | mesh:C005682 | ||
| Dihydroceramide | NA | mesh:C109343 | ||
| Glucosylceramide | D-glucosyl-N-acylsphingosine | mesh:D005963 | Glucosylceramides | chebi:18368 |
| 1-phosphate | NA | mesh:D010710 | ||
| ESerine | Physostigmine | mesh:D010830 | physostigmine | chebi:27953 |
| Sphingomyelin | NA | mesh:D013109 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|