Schematic presentation of Akt-mTOR signaling

Schematic presentation of Akt-mTOR signaling. Akt stimulates mTORC1 and 2 complex activities which leads to downstream signaling as well as both negative (mTORC1) and positive (mTORC2) feedback loops.
Schematic presentation of Akt-mTOR signaling
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Publication

THE PI3K-AKT-mTOR PATHWAY IN INITIATION AND PROGRESSION OF THYROID TUMORS. () Motoyasu Saji, et al. Mol Cell Endocrinol. ;321(1):20-28. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Tie 38559
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym InR 42549
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PDK-1 PDK-1 ncbigene_synonym Pdk1 38017
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates Rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates PDK-1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK-1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates Rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents PDK-1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK-1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents TSC1 TSC1 ncbigene_symbol Tsc1 64930
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents Raptor RAPTOR ncbigene_synonym Rptor 74370
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents Rictor RICTOR ncbigene_symbol Rictor 78757
Mus musculus Rodents Rheb RHEB ncbigene_symbol Rheb 19744
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents PDK-1 PDK1 ncbigene_symbol Pdk1 116551
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents TSC1 TSC1 ncbigene_symbol Tsc1 60445
Rattus norvegicus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 24855
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents Rictor RICTOR ncbigene_symbol Rictor 310131
Rattus norvegicus Rodents Rheb RHEB ncbigene_symbol Rheb 26954
Gallus gallus Vertebrates PDK-1 PDK1 ncbigene_symbol PDK1 425972
Gallus gallus Vertebrates TSC1 TSC1 ncbigene_symbol TSC1 417166
Gallus gallus Vertebrates TSC2 TSC2 ncbigene_symbol TSC2 416552
Gallus gallus Vertebrates MTOR MTOR ncbigene_symbol MTOR 419455
Gallus gallus Vertebrates Rictor RICTOR ncbigene_symbol RICTOR 427447
Gallus gallus Vertebrates Rheb RHEB ncbigene_symbol RHEB 420434
Danio rerio Vertebrates PDK-1 PDK1 ncbigene_symbol pdk1 555840
Danio rerio Vertebrates TSC1 TSC1 ncbigene_synonym tsc1b 100330617
Danio rerio Vertebrates TSC2 TSC2 ncbigene_symbol tsc2 567524
Danio rerio Vertebrates MTOR MTOR ncbigene_symbol mtor 324254
Danio rerio Vertebrates Rictor RICTOR ncbigene_synonym rictorb 561835
Danio rerio Vertebrates Rheb RHEB ncbigene_symbol rheb 393702
Danio rerio Vertebrates Rheb RHEB ncbigene_synonym rhebl1 767781

Chemical mentions

Word Match MeSH Name ChEBI
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID