IFNG signaling through the JAK/STAT1 pathway

Schematic of IFNG signaling through the JAK/STAT1 pathway. Binding of IFNG to its receptor results in activation of the JAKs, which phosphorylate cytoplasmic monomers of STAT1. Phosphorylated STAT1 dimerizes, translocates to the nucleus, and activates transcription from gene promoters containing GAS (primary responses), such as IRF1. In the secondary responses, IRF1 activates transcription of IRF2, CDKN1A, caspases, and the MHC class Ia genes by binding IFN response elements (IRE), whereas STAT1 and IRF1 cooperate to transactivate expression of other genes, such as guanylate binding protein (GBP), PSMB8, PSMB9, and CIITA. P, phosphorylated.
IFNG signaling through the JAK/STAT1 pathway
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Publication

Interferon Gamma in Successful Pregnancies. (2009) Shawn P. Murphy, et al. Biol Reprod. 2009 May;80(5):848-859. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates IFNG IFNG ncbigene_symbol IFNG 3458
Homo sapiens Primates JAK1 JAK1 ncbigene_symbol JAK1 3716
Homo sapiens Primates JAK2 JAK2 ncbigene_symbol JAK2 3717
Homo sapiens Primates STAT1 STAT1 ncbigene_symbol STAT1 6772
Homo sapiens Primates ICAM1 ICAM1 ncbigene_symbol ICAM1 3383
Homo sapiens Primates IRF1 IRF1 ncbigene_symbol IRF1 3659
Homo sapiens Primates GAS GAS ncbigene_synonym GAST 2520
Homo sapiens Primates GAS GAS ncbigene_synonym GALNS 2588
Homo sapiens Primates GAS GAS ncbigene_synonym PAGR1 79447
Homo sapiens Primates IRF2 IRF2 ncbigene_symbol IRF2 3660
Homo sapiens Primates GBP GBP ncbigene_synonym HADHA 3030
Homo sapiens Primates GBP GBP ncbigene_synonym LGALS1 3956
Homo sapiens Primates GBP GBP ncbigene_synonym PIAS1 8554
Homo sapiens Primates GBP GBP ncbigene_synonym TMEM132A 54972
Homo sapiens Primates CDKN1A CDKN1A ncbigene_symbol CDKN1A 1026
Homo sapiens Primates CDKN1A CDKN1A ncbigene_synonym CDPF1 150383
Homo sapiens Primates PSMB8 PSMB8 ncbigene_symbol PSMB8 5696
Homo sapiens Primates PSMB9 PSMB9 ncbigene_symbol PSMB9 5698
Homo sapiens Primates caspases CASPASE famplex_relations CASP1 834
Homo sapiens Primates caspases CASPASE famplex_relations CASP2 835
Homo sapiens Primates caspases CASPASE famplex_relations CASP4 837
Homo sapiens Primates caspases CASPASE famplex_relations CASP5 838
Homo sapiens Primates caspases CASPASE famplex_relations CASP6 839
Homo sapiens Primates caspases CASPASE famplex_relations CASP8 841
Homo sapiens Primates caspases CASPASE famplex_relations CASP9 842
Homo sapiens Primates caspases CASPASE famplex_relations CASP10 843
Homo sapiens Primates caspases CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates caspases CASPASE famplex_relations CASP14 23581
Homo sapiens Primates caspases CASPASE famplex_relations CASP3 836
Homo sapiens Primates caspases CASPASE famplex_relations CASP7 840
Homo sapiens Primates MHC MHC ncbigene_synonym HLA-C 3107
Homo sapiens Primates IFNGR2 IFNGR2 ncbigene_symbol IFNGR2 3460
Homo sapiens Primates IFNGR1 IFNGR1 ncbigene_symbol IFNGR1 3459

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID