Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1

Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1. (a) Two mTOR complexes, mTORC1 and mTORC2, and their components. mTORC1 is the protein complex responsible for autophagy induction in response to nutrient starvation, stress and reduced growth factor signaling. mTORC2 regulates autophagy via Akt-FoxO3 in skeletal muscle cells in response to a fasting condition [,]. (b) The signaling pathways upstream of mTORC1 that regulate cell growth and autophagy in response to nutrient levels, growth factors, and stress.
Regulation of the mTOR pathway by nutrients (amino acids, glucose), stress and insulin/IGF-1
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

mTOR regulation of autophagy. () Chang Hwa Jung, et al. FEBS Lett. ;584(7):1287-1295. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates low LOW ncbigene_symbol Low 44325
Drosophila melanogaster Invertebrates Sin1 SIN1 ncbigene_symbol Sin1 36604
Drosophila melanogaster Invertebrates rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates PRAS40 PRAS40 ncbigene_symbol PRAS40 26067067
Drosophila melanogaster Invertebrates raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates PI3KI PI3KI ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates lowATP/AMP AMP ncbigene_synonym Amph 36383
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym ATPsynbeta 43829
Drosophila melanogaster Invertebrates ATP ATP ncbigene_synonym Atpalpha 48971
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates GAL GAL ncbigene_symbol Gal 33839
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates GL GL ncbigene_symbol gl 42210
Drosophila melanogaster Invertebrates GL GL ncbigene_synonym sno 32273
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates TSC1/2- TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates GAPDH GAPDH ncbigene_synonym Gapdh2 32545
Drosophila melanogaster Invertebrates GAPDH GAPDH ncbigene_synonym Gpdh1 33824
Drosophila melanogaster Invertebrates GAPDH GAPDH ncbigene_synonym Gapdh1 35728
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates Rag RAG ncbigene_symbol rag 252474
Drosophila melanogaster Invertebrates Rag RAG ncbigene_synonym RagA-B 41071
Drosophila melanogaster Invertebrates Rag RAG ncbigene_synonym rags 252475
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Homo sapiens Primates IGF-1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates growthfactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates IRŞ-1 IR1 ncbigene_synonym NISCH 11188
Homo sapiens Primates IRŞ-1 IRS1 ncbigene_symbol IRS1 3667
Homo sapiens Primates Sin1 SIN1 ncbigene_synonym MAPKAP1 79109
Homo sapiens Primates rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates PRAS40 PRAS40 ncbigene_synonym AKT1S1 84335
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MTOR 2475
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates lowATP/AMP AMP ncbigene_synonym APRT 353
Homo sapiens Primates lowATP/AMP AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates GAL GAL ncbigene_symbol GAL 51083
Homo sapiens Primates GAL GAL ncbigene_synonym GALP 85569
Homo sapiens Primates DEPTOR DEPTOR ncbigene_symbol DEPTOR 64798
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates -REDD1 REDD1 ncbigene_synonym DDIT4 54541
Homo sapiens Primates TSC1/2- TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/2- TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates GAPDH GAPDH ncbigene_symbol GAPDH 2597
Homo sapiens Primates GAPDH GAPDH ncbigene_synonym GAPDHP44 100240709
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Mus musculus Rodents IGF-1 IGF-1 ncbigene_synonym Igf1 16000
Mus musculus Rodents low LOW ncbigene_synonym NA 20997
Mus musculus Rodents IRŞ-1 IRS-1 ncbigene_synonym Irs1 16367
Mus musculus Rodents Sin1 SIN1 ncbigene_synonym Mapkap1 227743
Mus musculus Rodents rictor RICTOR ncbigene_symbol Rictor 78757
Mus musculus Rodents PRAS40 PRAS40 ncbigene_synonym Akt1s1 67605
Mus musculus Rodents raptor RAPTOR ncbigene_synonym Rptor 74370
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents GAL GAL ncbigene_symbol Gal 14419
Mus musculus Rodents GAL GAL ncbigene_synonym Ggta1 14594
Mus musculus Rodents DEPTOR DEPTOR ncbigene_symbol Deptor 97998
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents -REDD1 REDD1 ncbigene_synonym Ddit4 74747
Mus musculus Rodents TSC1/2- TSC1 ncbigene_symbol Tsc1 64930
Mus musculus Rodents GAPDH GAPDH ncbigene_symbol Gapdh 14433
Mus musculus Rodents Rheb RHEB ncbigene_symbol Rheb 19744
Mus musculus Rodents GTPases GTPASE ncbigene_synonym Racgap1 26934
Schizosaccharomyces pombe Plants and Fungi IRŞ-1 IRS1 ncbigene_symbol irs1 2541245
Schizosaccharomyces pombe Plants and Fungi Sin1 SIN1 ncbigene_symbol sin1 2542972
Schizosaccharomyces pombe Plants and Fungi TSC1/2- TSC1 ncbigene_symbol tsc1 2541869
Danio rerio Vertebrates IGF-1 IGF-1 ncbigene_synonym igf1 114433
Danio rerio Vertebrates receptor RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates receptor RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates IRŞ-1 IRS1 ncbigene_symbol irs1 559281
Danio rerio Vertebrates rictor RICTOR ncbigene_synonym rictorb 561835
Danio rerio Vertebrates PTEN PTEN ncbigene_synonym ptenb 368415
Danio rerio Vertebrates MTOR MTOR ncbigene_symbol mtor 324254
Danio rerio Vertebrates GAL GAL ncbigene_symbol gal 100006361
Danio rerio Vertebrates DEPTOR DEPTOR ncbigene_symbol deptor 768177
Danio rerio Vertebrates -REDD1 REDD1 ncbigene_synonym ddit4 378866
Danio rerio Vertebrates TSC1/2- TSC1 ncbigene_synonym tsc1b 100330617
Danio rerio Vertebrates GAPDH GAPDH ncbigene_symbol gapdh 317743
Danio rerio Vertebrates GAPDH GAPDH ncbigene_synonym gapdhs 406367
Danio rerio Vertebrates Rheb RHEB ncbigene_symbol rheb 393702
Danio rerio Vertebrates Rheb RHEB ncbigene_synonym rhebl1 767781

Chemical mentions

Word Match MeSH Name ChEBI
glucose Glucose mesh:D005947 D-glucopyranose chebi:4167
glutamine Glutamine mesh:D005973 glutamine chebi:28300
glutamine leucine Glutamine mesh:D005973 glutamine chebi:28300
glutamine leucine Leucine mesh:D007930 L-leucine chebi:15603
rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID