Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P

Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P. ipecacuanha. Probable O-methylation steps in ipecac alkaloid biosynthesis are shown. IpeGlu1 has been identified by Ref. . The alkaloidal glucosides having an R-configuration, methylalangiside and 6,7-O,O-dimethylipecoside, both of which have two methoxy groups on the isoquinoline skeleton, have not yet been identified in P. ipecacuanha.
Schematic representation of the biosynthetic pathway of emetine, cephaeline, and related alkaloidal glucosides in P
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Publication

Three New O-Methyltransferases Are Sufficient for All O-Methylation Reactions of Ipecac Alkaloid Biosynthesis in Root Culture of Psychotria ipecacuanha. (2010) Taiji Nomura, et al. J Biol Chem. 2010 Mar 5;285(10):7722-7738. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates HO-A HOA ncbigene_synonym MATN3 4148
Homo sapiens Primates NAC NAC ncbigene_synonym XK 7504
Homo sapiens Primates NAC NAC ncbigene_synonym NLRP1 22861
Homo sapiens Primates MeO-8 ME5 ncbigene_synonym FAT1 2195
Homo sapiens Primates MeO-8 ME6 ncbigene_synonym PCDHGB7 56099
Homo sapiens Primates MeO-8 ME3 ncbigene_symbol ME3 10873
Homo sapiens Primates MeO-8 ME3 ncbigene_synonym PCDHGA5 56110
Homo sapiens Primates MeO-8 ME1 ncbigene_symbol ME1 4199
Homo sapiens Primates MeO-8 ME1 ncbigene_synonym PCDHB16 57717
Homo sapiens Primates MeO-8 ME4 ncbigene_synonym PCDHB17P 54661
Homo sapiens Primates MeO-8 ME2 ncbigene_symbol ME2 4200
Homo sapiens Primates MeO-8 ME2 ncbigene_synonym CELSR1 9620
Homo sapiens Primates MeO-8 ME2 ncbigene_synonym PCDHB11 56125
Drosophila melanogaster Invertebrates R=H, RH ncbigene_symbol rh 252528
Drosophila melanogaster Invertebrates Me, ME ncbigene_symbol Me 45901
Drosophila melanogaster Invertebrates NAC NAC ncbigene_symbol nac 40981
Drosophila melanogaster Invertebrates NAC NAC ncbigene_synonym Nacalpha 36409
Drosophila melanogaster Invertebrates CHO CHO ncbigene_synonym VhaAC39-1 31342
Drosophila melanogaster Invertebrates MeO-8 ME1 ncbigene_synonym Men 47173
Danio rerio Vertebrates MeO-8 ME3 ncbigene_symbol me3 492719
Danio rerio Vertebrates MeO-8 ME1 ncbigene_symbol me1 768196
Danio rerio Vertebrates MeO-8 ME2 ncbigene_symbol me2 445233

Chemical mentions

Word Match MeSH Name ChEBI
Secologanin NA mesh:C021086
Demethylisoalangiside Demethylisoalangiside mesh:C450171 demethylisoalangiside chebi:4397
Alangiside NA mesh:C504105
alangiside NA mesh:C504105
CHO Protoemetine Protoemetine mesh:C570574 protoemetine chebi:8589
Dopamine Dopamine mesh:D004298 dopamine chebi:18243

Disease mentions

Word Match MeSH Name DOID