A signaling cascade activated by opiates
Schematic of a signaling cascade activated by opiates. Opiates via the μ-opioid receptor activates the dopiminergic pathway leading to the increased DARPP-32 phosphorylation at Thr34 and increased PP-1 inhibition which modulates ERK activation and consequently the expression of the downstream transcriptional molecule CREB.
Publication
THERAPEUTIC TARGETING OF “DARPP-32”: A KEY SIGNALING MOLECULE IN THE DOPIMINERGIC PATHWAY FOR THE TREATMENT OF OPIATE ADDICTION. () Supriya D. Mahajan, et al. Int Rev Neurobiol. ;88:199-222. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | D1R | D1R | ncbigene_synonym | DRD1 | 1812 |
| Homo sapiens | Primates | Cdk5 | CDK5 | ncbigene_symbol | CDK5 | 1020 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKAR1A | 5573 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKAR1B | 5575 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKAR2A | 5576 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKAR2B | 5577 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKACA | 5566 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKACB | 5567 |
| Homo sapiens | Primates | PKA | PKA | famplex_relations | PRKACG | 5568 |
| Homo sapiens | Primates | DARPP-32 | DARPP-32 | ncbigene_synonym | PPP1R1B | 84152 |
| Homo sapiens | Primates | PP2A | PP2A | ncbigene_synonym | PTPA | 5524 |
| Homo sapiens | Primates | PP1 | PP1 | ncbigene_synonym | PPA1 | 5464 |
| Homo sapiens | Primates | PP1 | PP1 | ncbigene_synonym | NPY4R | 5540 |
| Homo sapiens | Primates | PP1 | PP1 | ncbigene_synonym | NPY4R2 | 100996758 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Homo sapiens | Primates | CREB | CREB | ncbigene_synonym | CREB1 | 1385 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3 | 10488 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB5 | 9586 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L1 | 90993 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L2 | 64764 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L3 | 84699 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREB3L4 | 148327 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | CREM | 1390 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | ATF1 | 466 |
| Homo sapiens | Primates | CREB | CREB | famplex_relations | ATF2 | 1386 |
| Homo sapiens | Primates | via | VIA | ncbigene_synonym | SEMA6A | 57556 |
| Mus musculus | Rodents | Cdk5 | CDK5 | ncbigene_symbol | Cdk5 | 12568 |
| Mus musculus | Rodents | DARPP-32 | DARPP-32 | ncbigene_synonym | Ppp1r1b | 19049 |
| Mus musculus | Rodents | PP2A | PP2A | ncbigene_synonym | Ppp2ca | 19052 |
| Mus musculus | Rodents | PP2A | PP2A | ncbigene_synonym | Ppp2r1a | 51792 |
| Mus musculus | Rodents | PP1 | PP1 | ncbigene_synonym | Ppp1cc | 19047 |
| Mus musculus | Rodents | PP1 | PP1 | ncbigene_synonym | Npy4r | 19065 |
| Mus musculus | Rodents | ERK | ERK | ncbigene_synonym | Ephb2 | 13844 |
| Mus musculus | Rodents | ERK | ERK | ncbigene_synonym | Mapk1 | 26413 |
| Mus musculus | Rodents | CREB | CREB | ncbigene_synonym | Creb1 | 12912 |
| Mus musculus | Rodents | via | VIA | ncbigene_synonym | Sema6a | 20358 |
| Drosophila melanogaster | Invertebrates | Cdk5 | CDK5 | ncbigene_symbol | Cdk5 | 36727 |
| Drosophila melanogaster | Invertebrates | PKA | PKA | ncbigene_synonym | Pka-C1 | 34284 |
| Drosophila melanogaster | Invertebrates | PKA | PKA | ncbigene_synonym | Pka-R2 | 36041 |
| Drosophila melanogaster | Invertebrates | PKA | PKA | ncbigene_synonym | Pka-C3 | 39733 |
| Drosophila melanogaster | Invertebrates | PKA | PKA | ncbigene_synonym | Pka-R1 | 40305 |
| Drosophila melanogaster | Invertebrates | PKA | PKA | ncbigene_synonym | Pka-C2 | 43644 |
| Drosophila melanogaster | Invertebrates | PP2A | PP2A | ncbigene_synonym | wrd | 42169 |
| Drosophila melanogaster | Invertebrates | PP2A | PP2A | ncbigene_synonym | wdb | 43312 |
| Drosophila melanogaster | Invertebrates | PP2A | PP2A | ncbigene_synonym | mts | 45959 |
| Drosophila melanogaster | Invertebrates | PP2A | PP2A | ncbigene_synonym | tws | 47877 |
| Drosophila melanogaster | Invertebrates | PP2A | PP2A | ncbigene_synonym | Pp2A-29B | 2768940 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | Pp1alpha-96A | 42922 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | flw | 44289 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | br | 44505 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | Pp4-19C | 45031 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | Pp1-13C | 48531 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | Pp1-87B | 49260 |
| Drosophila melanogaster | Invertebrates | PP1 | PP1 | ncbigene_synonym | PpD6 | 49780 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | Erk7 | 31877 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | rl | 3354888 |
| Drosophila melanogaster | Invertebrates | CREB | CREB | ncbigene_synonym | CrebB | 32817 |
| Drosophila melanogaster | Invertebrates | CREB | CREB | ncbigene_synonym | CrebA | 39682 |
| Drosophila melanogaster | Invertebrates | via | VIA | ncbigene_synonym | levy | 37728 |
| Drosophila melanogaster | Invertebrates | via | VIA | ncbigene_synonym | COX6AL2 | 40066 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Dopamine | Dopamine | mesh:D004298 | dopamine | chebi:18243 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|