Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands

Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands. DHT-stimulated fibroblasts increase the expression of FGF7 and FGF10 which bind to epithelial FGFR2b. FGFR2b signaling increases expression of Shh which activates Gli-dependent MC5R, involved in sebocyte differentiation and lipogenesis. Both, FGFR2b as well as IGF1R activate MAPK- and PI3K-dependent pathways, especially the upregulation of SREBP-1, the major transcription factor of lipogenesis. Androgen-mediated upregulation of EGFR-signal transduction increases the transcription factor p63 which induces synthesis of FGFR2b. IGF-1 stimulates 5α-recuctase activity. IGF-1 activates AR by PI3K-dependent phosphorylation of Foxo-1. Keratinoycyte-derived IL-1α induces dermal expression of FGF7 thereby upregulating keratinocyte proliferation in a double paracrine pathway.
Synopsis of FGFR2b-mediated dermal-epithelial signaling in keratinocytes and sebocytes of sebaceous glands
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Publication

Role of FGFR2-signaling in the pathogenesis of acne. (2009) Bodo C Melnik. Dermatoendocrinol. 2009 May-Jun;1(3):141-156. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates a-MSH AMSH ncbigene_synonym STAMBP 10617
Homo sapiens Primates Shh SHH ncbigene_symbol SHH 6469
Homo sapiens Primates Gli GLI ncbigene_synonym GLI1 2735
Homo sapiens Primates SREBP-1 SREBP1 ncbigene_synonym SREBF1 6720
Homo sapiens Primates IL-1a IL-1A ncbigene_synonym IL1A 3552
Homo sapiens Primates CyclinD1 CCND1 ncbigene_symbol CCND1 595
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates p63 P63 ncbigene_synonym RPE65 6121
Homo sapiens Primates p63 P63 ncbigene_synonym UVRAG 7405
Homo sapiens Primates p63 P63 ncbigene_synonym TP63 8626
Homo sapiens Primates p63 P63 ncbigene_synonym CKAP4 10970
Homo sapiens Primates EGFR EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates IGF1R IGF1R ncbigene_symbol IGF1R 3480
Homo sapiens Primates EGF EGF ncbigene_symbol EGF 1950
Homo sapiens Primates FGF7 FGF7 ncbigene_symbol FGF7 2252
Homo sapiens Primates FGF10 FGF10 ncbigene_symbol FGF10 2255
Homo sapiens Primates IGF-1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates AR AR ncbigene_symbol AR 367
Mus musculus Rodents a-MSH A-MSH ncbigene_synonym Pomc 18976
Mus musculus Rodents Shh SHH ncbigene_symbol Shh 20423
Mus musculus Rodents Gli G2 ncbigene_synonym Gabrg2 14406
Mus musculus Rodents SREBP-1 SREBP1 ncbigene_synonym Srebf1 20787
Mus musculus Rodents IL-1a IL-1A ncbigene_synonym Il1a 16175
Mus musculus Rodents CyclinD1 CCND1 ncbigene_symbol Ccnd1 12443
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents p63 P63 ncbigene_synonym Taf1b 21340
Mus musculus Rodents p63 P63 ncbigene_synonym Tcp1 21454
Mus musculus Rodents p63 P63 ncbigene_synonym Trp63 22061
Mus musculus Rodents p63 P63 ncbigene_synonym Ckap4 216197
Mus musculus Rodents EGFR EGFR ncbigene_symbol Egfr 13649
Mus musculus Rodents IGF1R IGF1R ncbigene_symbol Igf1r 16001
Mus musculus Rodents EGF EGF ncbigene_symbol Egf 13645
Mus musculus Rodents FGF7 FGF7 ncbigene_symbol Fgf7 14178
Mus musculus Rodents FGF10 FGF10 ncbigene_symbol Fgf10 14165
Mus musculus Rodents IGF-1 IGF-1 ncbigene_synonym Igf1 16000
Mus musculus Rodents AR AR ncbigene_symbol Ar 11835
Danio rerio Vertebrates Shh SHH ncbigene_synonym shha 30269
Danio rerio Vertebrates Gli GLI ncbigene_symbol gli 30097
Danio rerio Vertebrates CyclinD1 CCND1 ncbigene_symbol ccnd1 30222
Danio rerio Vertebrates p63 P63 ncbigene_synonym tp63 260407
Danio rerio Vertebrates EGFR EGFR ncbigene_synonym egfra 378478
Danio rerio Vertebrates EGF EGF ncbigene_symbol egf 403045
Danio rerio Vertebrates EGF EGF ncbigene_synonym celsr1a 368436
Danio rerio Vertebrates FGF7 FGF7 ncbigene_symbol fgf7 493181
Danio rerio Vertebrates FGF10 FGF10 ncbigene_synonym fgf10a 359830
Danio rerio Vertebrates IGF-1 IGF-1 ncbigene_synonym igf1 114433
Danio rerio Vertebrates AR AR ncbigene_symbol ar 100005148

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA