HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways

Mechanisms of HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways. TLR-3 signals in a MYD88-independent manner to induce interferon production, while TLR-9 activates inflammatory cytokines and interferons through a MYD88-dependent pathway in response to HSV-1 infection. HSV-1 blocks ND10 accumulation in the nucleus, PKR activity, and Jak/STAT signaling with a cumulative effect that renders the infected cell highly susceptible to viral replication.
HSV-1-mediated antagonism of TLR-dependent, anti-viral pathways
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Publication

Herpes Simplex Type I (HSV-1) Infection of the Nervous System: Is an Immune Response a Good Thing?. () Christopher D. Conrady, et al. J Neuroimmunol. ;220(1-2):1-9. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents TLR-3 TLR3 ncbigene_symbol Tlr3 142980
Mus musculus Rodents TLR9 TLR9 ncbigene_symbol Tlr9 81897
Mus musculus Rodents Step STEP ncbigene_synonym Ptpn5 19259
Mus musculus Rodents HSV-1 HSV-1 ncbigene_synonym Ifx 107851
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam2 225471
Mus musculus Rodents PKR PKR ncbigene_synonym Eif2ak2 19106
Mus musculus Rodents MYD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents RNASEL RNASEL ncbigene_symbol Rnasel 24014
Mus musculus Rodents IRAK IRAK ncbigene_synonym Irak1 16179
Mus musculus Rodents IRF3 IRF3 ncbigene_symbol Irf3 54131
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents P.T. PT ncbigene_symbol Pt 109555
Homo sapiens Primates TLR-3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates TLR9 TLR9 ncbigene_symbol TLR9 54106
Homo sapiens Primates TLR TLR famplex_relations TLR1 7096
Homo sapiens Primates TLR TLR famplex_relations TLR2 7097
Homo sapiens Primates TLR TLR famplex_relations TLR4 7099
Homo sapiens Primates TLR TLR famplex_relations TLR5 7100
Homo sapiens Primates TLR TLR famplex_relations TLR6 10333
Homo sapiens Primates TLR TLR famplex_relations TLR7 51284
Homo sapiens Primates TLR TLR famplex_relations TLR8 51311
Homo sapiens Primates TLR TLR famplex_relations TLR10 81793
Homo sapiens Primates Step STEP ncbigene_synonym PTPN5 84867
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates PKR PKR ncbigene_synonym EIF2AK2 5610
Homo sapiens Primates MYD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates RNASEL RNASEL ncbigene_symbol RNASEL 6041
Homo sapiens Primates IRAK IRAK ncbigene_synonym IRAK1 3654
Homo sapiens Primates Stat STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates Stat STAT famplex_relations STAT1 6772
Homo sapiens Primates Stat STAT famplex_relations STAT2 6773
Homo sapiens Primates Stat STAT famplex_relations STAT3 6774
Homo sapiens Primates Stat STAT famplex_relations STAT4 6775
Homo sapiens Primates Stat STAT famplex_relations STAT6 6778
Homo sapiens Primates Stat STAT famplex_relations STAT5A 6776
Homo sapiens Primates Stat STAT famplex_relations STAT5B 6777
Homo sapiens Primates Jak JAK famplex_relations JAK1 3716
Homo sapiens Primates Jak JAK famplex_relations JAK2 3717
Homo sapiens Primates Jak JAK famplex_relations JAK3 3718
Homo sapiens Primates Jak JAK famplex_relations TYK2 7297
Homo sapiens Primates IRF3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates IRF IRF ncbigene_synonym TRIM63 84676
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNK 56832
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNW1 3467
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA1 3439
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA2 3440
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA4 3441
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA5 3442
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA6 3443
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA7 3444
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA8 3445
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA10 3446
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA13 3447
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA14 3448
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA16 3449
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA17 3451
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNA21 3452
Homo sapiens Primates Interferons INTERFERON famplex_relations IFNB1 3456
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL10 3627
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL11 6373
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL12 6387
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL13 10563
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL14 9547
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL9 4283
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations PF4 5196
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL1 2919
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL2 2920
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL3 2921
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL5 6374
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL6 6372
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations CXCL8 3576
Homo sapiens Primates Chemokines CHEMOKINE famplex_relations PPBP 5473
Cricetulus griseus Rodents TLR-3 TLR3 ncbigene_symbol Tlr3 100750454
Cricetulus griseus Rodents TLR9 TLR9 ncbigene_symbol Tlr9 103160136
Cricetulus griseus Rodents MYD88 MYD88 ncbigene_symbol Myd88 100775060
Cricetulus griseus Rodents RNASEL RNASEL ncbigene_symbol Rnasel 100763013
Cricetulus griseus Rodents IRF3 IRF3 ncbigene_symbol Irf3 100765676
Cricetulus griseus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 100753700
Cavia porcellus Rodents TLR-3 TLR3 ncbigene_symbol Tlr3 100135634
Cavia porcellus Rodents MYD88 MYD88 ncbigene_symbol Myd88 100733381
Cavia porcellus Rodents RNASEL RNASEL ncbigene_symbol Rnasel 100192397
Cavia porcellus Rodents IRF3 IRF3 ncbigene_symbol Irf3 100724910
Cavia porcellus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 100724447
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym 18w 37277
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym tok 42944
Drosophila melanogaster Invertebrates TLR TLR ncbigene_synonym tlr-2 44349
Drosophila melanogaster Invertebrates Step STEP ncbigene_symbol step 35425
Drosophila melanogaster Invertebrates MYD88 MYD88 ncbigene_symbol Myd88 35956
Drosophila melanogaster Invertebrates Stat STAT ncbigene_synonym Stat92E 42428
Drosophila melanogaster Invertebrates Jak JAK ncbigene_synonym hop 32080
Drosophila melanogaster Invertebrates Jak JAK ncbigene_synonym bsk 44801
Drosophila melanogaster Invertebrates IRF IRF ncbigene_synonym Irp-1B 41269
Drosophila melanogaster Invertebrates IRF IRF ncbigene_synonym Irp-1A 42689
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates MA MA ncbigene_synonym E(spl)malpha-BFM 43153
Drosophila melanogaster Invertebrates KR KR ncbigene_symbol Kr 38012
Drosophila melanogaster Invertebrates P.T. PT ncbigene_symbol pt 44528
Danio rerio Vertebrates TLR-3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates TLR9 TLR9 ncbigene_symbol tlr9 403128
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates PKR PKR ncbigene_synonym eif2ak2 100001092
Danio rerio Vertebrates MYD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates Stat STAT ncbigene_synonym stat1b 368481
Danio rerio Vertebrates Stat STAT ncbigene_synonym stat4 368519
Danio rerio Vertebrates IRF3 IRF3 ncbigene_symbol irf3 564854
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID