Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse
Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse. Adrenal expression patterns of genes involved in cholesterol biosynthesis were mapped onto a biochemical pathway diagram with GenMAPP. The statistically significant and global underexpression of the pathway, including 2.60-fold underexpression of HMG-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis, suggests a reduction in de novo cholesterol biosynthesis in the adrenal gland of the Chga knockout mouse. Genes overexpressed in the Chga knockout are colored red, genes underexpressed in the Chga knockout are colored blue, genes lacking a statistically significant change are colored gray, and genes without expression data (i.e., the gene lacked a probe on the microarray) are shown in white. Numbers adjacent to genes indicate the fold change of differential expression. A positive number indicates a gene that is overexpressed in the knockout (Chga KO mean signal/wild-type mean signal), and a negative number refers to a gene that is underexpressed in the knockout (−wild-type mean signal/Chga KO mean signal).

Publication
Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. (2010) Ryan S. Friese, et al. Physiol Genomics. 2010 Feb;40(3):195-207. Figure: F2.Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
---|---|---|---|---|---|---|
Mus musculus | Rodents | Dhcr7 | DHCR7 | ncbigene_symbol | Dhcr7 | 13360 |
Mus musculus | Rodents | Hmgcr | HMGCR | ncbigene_symbol | Hmgcr | 15357 |
Mus musculus | Rodents | Chga | CHGA | ncbigene_symbol | Chga | 12652 |
Mus musculus | Rodents | Sc5d | SC5D | ncbigene_symbol | Sc5d | 235293 |
Mus musculus | Rodents | Mvk | MVK | ncbigene_symbol | Mvk | 17855 |
Mus musculus | Rodents | Nsdhl | NSDHL | ncbigene_symbol | Nsdhl | 18194 |
Mus musculus | Rodents | Sc4mol | SC4MOL | ncbigene_synonym | Msmo1 | 66234 |
Mus musculus | Rodents | Cyp51 | CYP51 | ncbigene_symbol | Cyp51 | 13121 |
Mus musculus | Rodents | Pmvk | PMVK | ncbigene_symbol | Pmvk | 68603 |
Mus musculus | Rodents | Mvd | MVD | ncbigene_symbol | Mvd | 192156 |
Mus musculus | Rodents | Idi1 | IDI1 | ncbigene_symbol | Idi1 | 319554 |
Mus musculus | Rodents | Lss | LSS | ncbigene_symbol | Lss | 16987 |
Mus musculus | Rodents | Fdps | FDPS | ncbigene_symbol | Fdps | 110196 |
Mus musculus | Rodents | Sqle | SQLE | ncbigene_symbol | Sqle | 20775 |
Mus musculus | Rodents | Fdft1 | FDFT1 | ncbigene_symbol | Fdft1 | 14137 |
Homo sapiens | Primates | Dhcr7 | DHCR7 | ncbigene_symbol | DHCR7 | 1717 |
Homo sapiens | Primates | Hmgcr | HMGCR | ncbigene_symbol | HMGCR | 3156 |
Homo sapiens | Primates | Chga | CHGA | ncbigene_symbol | CHGA | 1113 |
Homo sapiens | Primates | Sc5d | SC5D | ncbigene_symbol | SC5D | 6309 |
Homo sapiens | Primates | Mvk | MVK | ncbigene_symbol | MVK | 4598 |
Homo sapiens | Primates | Nsdhl | NSDHL | ncbigene_symbol | NSDHL | 50814 |
Homo sapiens | Primates | Sc4mol | SC4MOL | ncbigene_synonym | MSMO1 | 6307 |
Homo sapiens | Primates | Cyp51 | CYP51 | ncbigene_synonym | CYP51A1 | 1595 |
Homo sapiens | Primates | Pmvk | PMVK | ncbigene_symbol | PMVK | 10654 |
Homo sapiens | Primates | Mvd | MVD | ncbigene_symbol | MVD | 4597 |
Homo sapiens | Primates | Idi1 | IDI1 | ncbigene_symbol | IDI1 | 3422 |
Homo sapiens | Primates | Lss | LSS | ncbigene_symbol | LSS | 4047 |
Homo sapiens | Primates | Lss | LSS | ncbigene_synonym | LMBR1 | 64327 |
Homo sapiens | Primates | Fdps | FDPS | ncbigene_symbol | FDPS | 2224 |
Homo sapiens | Primates | Sqle | SQLE | ncbigene_symbol | SQLE | 6713 |
Homo sapiens | Primates | Fdft1 | FDFT1 | ncbigene_symbol | FDFT1 | 2222 |
Danio rerio | Vertebrates | Dhcr7 | DHCR7 | ncbigene_symbol | dhcr7 | 378446 |
Danio rerio | Vertebrates | Chga | CHGA | ncbigene_symbol | chga | 450039 |
Danio rerio | Vertebrates | Sc5d | SC5D | ncbigene_symbol | sc5d | 447891 |
Danio rerio | Vertebrates | Mvk | MVK | ncbigene_symbol | mvk | 492477 |
Danio rerio | Vertebrates | Nsdhl | NSDHL | ncbigene_symbol | nsdhl | 550369 |
Danio rerio | Vertebrates | Sc4mol | SC4MOL | ncbigene_synonym | msmo1 | 406662 |
Danio rerio | Vertebrates | Cyp51 | CYP51 | ncbigene_symbol | cyp51 | 414331 |
Danio rerio | Vertebrates | Pmvk | PMVK | ncbigene_symbol | pmvk | 100003383 |
Danio rerio | Vertebrates | Mvd | MVD | ncbigene_synonym | mvda | 492781 |
Danio rerio | Vertebrates | Mvd | MVD | ncbigene_synonym | mvdb | 554764 |
Danio rerio | Vertebrates | Idi1 | IDI1 | ncbigene_symbol | idi1 | 553513 |
Danio rerio | Vertebrates | Lss | LSS | ncbigene_symbol | lss | 795400 |
Danio rerio | Vertebrates | Fdps | FDPS | ncbigene_symbol | fdps | 552997 |
Danio rerio | Vertebrates | Fdft1 | FDFT1 | ncbigene_symbol | fdft1 | 571911 |
Word | Match | MeSH | Name | ChEBI |
---|---|---|---|---|
Lathosterol | 5alpha-cholest-7-en-3beta-ol | mesh:C001521 | lathosterol | chebi:17168 |
Squalene-2,3-Epoxide | NA | mesh:C002821 | ||
Cholesterol | Cholesterol | mesh:D002784 | cholesterol | chebi:16113 |
Fatty Acid | Fatty Acids | mesh:D005227 | fatty acid | chebi:35366 |
Lanosterol | Lanosterol | mesh:D007810 | lanosterol | chebi:16521 |
Mevalonate | NA | mesh:D008798 | ||
Mevalonate-5-P | NA | mesh:D008798 | ||
Mevalonate-5-PP | NA | mesh:D008798 | ||
Squalene | Squalene | mesh:D013185 | squalene | chebi:15440 |
Disease mentions
Word | Match | MeSH | Name | DOID |
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