Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse

Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse. Adrenal expression patterns of genes involved in cholesterol biosynthesis were mapped onto a biochemical pathway diagram with GenMAPP. The statistically significant and global underexpression of the pathway, including 2.60-fold underexpression of HMG-CoA reductase (Hmgcr), the rate-limiting enzyme in cholesterol biosynthesis, suggests a reduction in de novo cholesterol biosynthesis in the adrenal gland of the Chga knockout mouse. Genes overexpressed in the Chga knockout are colored red, genes underexpressed in the Chga knockout are colored blue, genes lacking a statistically significant change are colored gray, and genes without expression data (i.e., the gene lacked a probe on the microarray) are shown in white. Numbers adjacent to genes indicate the fold change of differential expression. A positive number indicates a gene that is overexpressed in the knockout (Chga KO mean signal/wild-type mean signal), and a negative number refers to a gene that is underexpressed in the knockout (−wild-type mean signal/Chga KO mean signal).
Adrenal cholesterol biosynthesis pathway gene expression is globally underexpressed in the Chga knockout mouse

Publication

Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. (2010) Ryan S. Friese, et al. Physiol Genomics. 2010 Feb;40(3):195-207. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents Dhcr7 DHCR7 ncbigene_symbol Dhcr7 13360
Mus musculus Rodents Hmgcr HMGCR ncbigene_symbol Hmgcr 15357
Mus musculus Rodents Chga CHGA ncbigene_symbol Chga 12652
Mus musculus Rodents Sc5d SC5D ncbigene_symbol Sc5d 235293
Mus musculus Rodents Mvk MVK ncbigene_symbol Mvk 17855
Mus musculus Rodents Nsdhl NSDHL ncbigene_symbol Nsdhl 18194
Mus musculus Rodents Sc4mol SC4MOL ncbigene_synonym Msmo1 66234
Mus musculus Rodents Cyp51 CYP51 ncbigene_symbol Cyp51 13121
Mus musculus Rodents Pmvk PMVK ncbigene_symbol Pmvk 68603
Mus musculus Rodents Mvd MVD ncbigene_symbol Mvd 192156
Mus musculus Rodents Idi1 IDI1 ncbigene_symbol Idi1 319554
Mus musculus Rodents Lss LSS ncbigene_symbol Lss 16987
Mus musculus Rodents Fdps FDPS ncbigene_symbol Fdps 110196
Mus musculus Rodents Sqle SQLE ncbigene_symbol Sqle 20775
Mus musculus Rodents Fdft1 FDFT1 ncbigene_symbol Fdft1 14137
Homo sapiens Primates Dhcr7 DHCR7 ncbigene_symbol DHCR7 1717
Homo sapiens Primates Hmgcr HMGCR ncbigene_symbol HMGCR 3156
Homo sapiens Primates Chga CHGA ncbigene_symbol CHGA 1113
Homo sapiens Primates Sc5d SC5D ncbigene_symbol SC5D 6309
Homo sapiens Primates Mvk MVK ncbigene_symbol MVK 4598
Homo sapiens Primates Nsdhl NSDHL ncbigene_symbol NSDHL 50814
Homo sapiens Primates Sc4mol SC4MOL ncbigene_synonym MSMO1 6307
Homo sapiens Primates Cyp51 CYP51 ncbigene_synonym CYP51A1 1595
Homo sapiens Primates Pmvk PMVK ncbigene_symbol PMVK 10654
Homo sapiens Primates Mvd MVD ncbigene_symbol MVD 4597
Homo sapiens Primates Idi1 IDI1 ncbigene_symbol IDI1 3422
Homo sapiens Primates Lss LSS ncbigene_symbol LSS 4047
Homo sapiens Primates Lss LSS ncbigene_synonym LMBR1 64327
Homo sapiens Primates Fdps FDPS ncbigene_symbol FDPS 2224
Homo sapiens Primates Sqle SQLE ncbigene_symbol SQLE 6713
Homo sapiens Primates Fdft1 FDFT1 ncbigene_symbol FDFT1 2222
Danio rerio Vertebrates Dhcr7 DHCR7 ncbigene_symbol dhcr7 378446
Danio rerio Vertebrates Chga CHGA ncbigene_symbol chga 450039
Danio rerio Vertebrates Sc5d SC5D ncbigene_symbol sc5d 447891
Danio rerio Vertebrates Mvk MVK ncbigene_symbol mvk 492477
Danio rerio Vertebrates Nsdhl NSDHL ncbigene_symbol nsdhl 550369
Danio rerio Vertebrates Sc4mol SC4MOL ncbigene_synonym msmo1 406662
Danio rerio Vertebrates Cyp51 CYP51 ncbigene_symbol cyp51 414331
Danio rerio Vertebrates Pmvk PMVK ncbigene_symbol pmvk 100003383
Danio rerio Vertebrates Mvd MVD ncbigene_synonym mvda 492781
Danio rerio Vertebrates Mvd MVD ncbigene_synonym mvdb 554764
Danio rerio Vertebrates Idi1 IDI1 ncbigene_symbol idi1 553513
Danio rerio Vertebrates Lss LSS ncbigene_symbol lss 795400
Danio rerio Vertebrates Fdps FDPS ncbigene_symbol fdps 552997
Danio rerio Vertebrates Fdft1 FDFT1 ncbigene_symbol fdft1 571911

Chemical mentions

Word Match MeSH Name ChEBI
Lathosterol 5alpha-cholest-7-en-3beta-ol mesh:C001521 lathosterol chebi:17168
Squalene-2,3-Epoxide NA mesh:C002821
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
Fatty Acid Fatty Acids mesh:D005227 fatty acid chebi:35366
Lanosterol Lanosterol mesh:D007810 lanosterol chebi:16521
Mevalonate NA mesh:D008798
Mevalonate-5-P NA mesh:D008798
Mevalonate-5-PP NA mesh:D008798
Squalene Squalene mesh:D013185 squalene chebi:15440

Disease mentions

Word Match MeSH Name DOID