Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN

Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN. In unstimulated cells, Keap 1 sequesters Nrf2 and bridges it to Cul-3-dependent ubiquitinase for ubiquitination. The ubiquitinated Nrf2 is then targeted for proteosomal degradation. Both PEITC and SFN can activate Nrf2, although through different mechanisms. PEITC activates Nrf2 through activation of MAPK pathway while SFN modifies thiol group of Keap1 and releases Nrf2 from Keap1 binding
Molecular targets in Nrf2/phase II enzymes pathway modulated by PEITC and SFN
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention. (2010) Ka Lung Cheung, et al. AAPS J. 2010 Mar;12(1):87-97. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SFN SFN ncbigene_symbol SFN 2810
Homo sapiens Primates SFN SFN ncbigene_synonym REXO2 25996
Homo sapiens Primates p38 P38 ncbigene_synonym CRK 1398
Homo sapiens Primates p38 P38 ncbigene_synonym MAPK14 1432
Homo sapiens Primates p38 P38 ncbigene_synonym MAPK1 5594
Homo sapiens Primates p38 P38 ncbigene_synonym AIMP2 7965
Homo sapiens Primates p38 P38 ncbigene_synonym GRAP2 9402
Homo sapiens Primates p38 P38 ncbigene_synonym AHSA1 10598
Homo sapiens Primates p38 P38 ncbigene_synonym POLDIP2 26073
Homo sapiens Primates p38 P38 famplex_relations MAPK11 5600
Homo sapiens Primates p38 P38 famplex_relations MAPK12 6300
Homo sapiens Primates p38 P38 famplex_relations MAPK13 5603
Homo sapiens Primates Keap1 KEAP1 ncbigene_symbol KEAP1 9817
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates Nrf2 NRF2 ncbigene_synonym GABPA 2551
Homo sapiens Primates Nrf2 NRF2 ncbigene_synonym NFE2L2 4780
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates Mafs MAF ncbigene_symbol MAF 4094
Homo sapiens Primates Mafs MAF famplex_relations MAFA 389692
Homo sapiens Primates Mafs MAF famplex_relations MAFB 9935
Homo sapiens Primates Mafs MAF famplex_relations MAFF 23764
Homo sapiens Primates Mafs MAF famplex_relations MAFG 4097
Homo sapiens Primates Mafs MAF famplex_relations MAFK 7975
Homo sapiens Primates -GSTM1 GSTM1 ncbigene_symbol GSTM1 2944
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_symbol UGT1A1 54658
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_synonym UGT1A10 54575
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_synonym UGT1A8 54576
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_synonym UGT1A7 54577
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_synonym UGT1A6 54578
Homo sapiens Primates -UGT1A1 UGT1A1 ncbigene_synonym UGT1A4 54657
Homo sapiens Primates pol POL ncbigene_synonym ERVW-4 100616496

Chemical mentions

Word Match MeSH Name ChEBI
PEITC NA mesh:C058305
Cys Cysteine mesh:D003545 cysteine chebi:15356

Disease mentions

Word Match MeSH Name DOID