Role of CobT in the late steps of AdoCbl biosynthesis

Role of CobT in the late steps of AdoCbl biosynthesis. This branch of the AdoCbl biosynthetic pathway is known as the NLA pathway. The black box in the inner membrane represents the corrinoid-specific ABC transporter BtuCD. The inset shows the chemical structure of AdoCbl; the coring ring in the scheme is represented by the rhomboid cartoon with the Co ion in the middle.
Role of CobT in the late steps of AdoCbl biosynthesis
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Publication

Functional Analysis of the Nicotinate Mononucleotide:5,6-Dimethylbenzimidazole Phosphoribosyltransferase (CobT) Enzyme, Involved in the Late Steps of Coenzyme B12 Biosynthesis in Salmonella enterica . (2010) Kathy R. Claas, et al. J Bacteriol. 2010 Jan;192(1):145-154. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates out OUT ncbigene_symbol out 32926
Drosophila melanogaster Invertebrates (Ado) ADO ncbigene_symbol ado 45988
Drosophila melanogaster Invertebrates de DE ncbigene_symbol de 248301
Drosophila melanogaster Invertebrates Cby CBY ncbigene_symbol Cby 42574
Drosophila melanogaster Invertebrates AP-P AP-P ncbigene_synonym ApepP 35029
Drosophila melanogaster Invertebrates HN HN ncbigene_symbol Hn 38871
Drosophila melanogaster Invertebrates O-P-a OPA ncbigene_symbol opa 40605
Drosophila melanogaster Invertebrates O-P-a OPA ncbigene_synonym CG7179 34059
Drosophila melanogaster Invertebrates O-P-a OPA ncbigene_synonym oculus-parvus 250616
Drosophila melanogaster Invertebrates DMB DMB ncbigene_synonym Gpb5 3355097
Drosophila melanogaster Invertebrates FMN) FMN ncbigene_synonym DAT 36849
Drosophila melanogaster Invertebrates DH DH ncbigene_symbol dh 247540
Drosophila melanogaster Invertebrates a-R-P ARP ncbigene_synonym Arfrp1 31841
Drosophila melanogaster Invertebrates a-R-P ARP ncbigene_synonym Arp6 32514
Drosophila melanogaster Invertebrates a-R-P ARP ncbigene_synonym Su(z)2 36432
Drosophila melanogaster Invertebrates a-R-P ARP ncbigene_synonym Arp1 41566
Drosophila melanogaster Invertebrates a-R-P AR ncbigene_symbol ar 44503
Drosophila melanogaster Invertebrates Cobs COB ncbigene_symbol cob 247517
Drosophila melanogaster Invertebrates HOe HOE ncbigene_synonym hoe1 249663
Drosophila melanogaster Invertebrates Na NA ncbigene_symbol na 45338
Drosophila melanogaster Invertebrates AMP+ AMP ncbigene_synonym Amph 36383
Drosophila melanogaster Invertebrates AP AP ncbigene_symbol ap 35509
Homo sapiens Primates out OUT ncbigene_synonym TCF23 150921
Homo sapiens Primates (Ado) ADO ncbigene_symbol ADO 84890
Homo sapiens Primates Cby CBY ncbigene_synonym CBY1 25776
Homo sapiens Primates AP-P APP ncbigene_symbol APP 351
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates NDP NDP ncbigene_symbol NDP 4693
Homo sapiens Primates FMN) FMN ncbigene_synonym FMN1 342184
Homo sapiens Primates a-R-P ARP ncbigene_synonym CRISP1 167
Homo sapiens Primates a-R-P ARP ncbigene_synonym RERE 473
Homo sapiens Primates a-R-P ARP ncbigene_synonym MANF 7873
Homo sapiens Primates a-R-P ARP ncbigene_synonym ARFRP1 10139
Homo sapiens Primates a-R-P AR ncbigene_symbol AR 367
Homo sapiens Primates HOHO HOHO ncbigene_synonym KCNK1 3775
Homo sapiens Primates Cobs COB ncbigene_synonym MMAB 326625
Homo sapiens Primates AMP+ AMP ncbigene_synonym APRT 353
Homo sapiens Primates AMP+ AMP ncbigene_synonym MFAP1 4236
Homo sapiens Primates Nm NM ncbigene_symbol NM 4827

Chemical mentions

Word Match MeSH Name ChEBI
AdoCbl-5-P NA mesh:C000913
Adenosylcobalamin NA mesh:C000913
Cobyric acid cobyric acid mesh:C012851 cobyric acid chebi:23345
Thr Threonine mesh:D013912 L-threonine chebi:16857

Disease mentions

Word Match MeSH Name DOID