Summary of Trif-biased signaling and selective p38 activation by sMLA

Summary of Trif-biased signaling and selective p38 activation by sMLA. Upon activating the TLR4 complex, sMLA only weakly induces downstream events known to be activated through the TRIF/TRAF6/TAK1 axis, such as activation of IKKα/β and JNK. These kinases are activated strongly by sDLA, which leads to increased activation of transcription factors required to activate COX-2 and MCP-1. In contrast, sMLA treatment results in equivalent IRF3 activation downstream of TLR4/TRIF and p38 activation as compared with sDLA; this signaling results in potent activation of not only TRIF-associated IP-10 but also proinflammatory TNFα and anti-inflammatory IL-10.

Publication

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A. (2009) Caglar Cekic, et al. J Biol Chem. 2009 Nov 13;284(46):31982-31991. Figure: F8. All organisms Homo sapiens Mus musculus Drosophila melanogaster Danio rerio

Disease mentions