Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C

Summary of glutathione (l-γ-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C. intestinalis including gene products (highlighted in gray) contributing to the biosynthesis of glutathione [GCLC, GCLM, GSS, GGT1, xCT (SLC7A11)], its use as a redox buffer [GLRX, GPX1, GSR], and as a conjugate in phase II detoxification [GSTA1, GSTM1, GSTP1, MRP2 (ABCC2)], as well as known transcriptional regulators [NRF2 (NFE2l2), KEAP1, MAFF, BACH1, LXRA (NR1H3), FXR (NR1H4), and RXRA]. ARE, antioxidant response element; HRE, hormone response element.
Summary of glutathione (l-Gamma-glutamyl-l-cysteinylglycine, GSH) homeostasis pathway identified in C
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Publication

Genomic analyses reveal a conserved glutathione homeostasis pathway in the invertebrate chordate Ciona intestinalis. (2009) Gerardo M. Nava, et al. Physiol Genomics. 2009 Nov;39(3):183-194. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates KEAP1 KEAP1 ncbigene_symbol KEAP1 9817
Homo sapiens Primates NRF2 NRF2 ncbigene_synonym GABPA 2551
Homo sapiens Primates NRF2 NRF2 ncbigene_synonym NFE2L2 4780
Homo sapiens Primates BACH1 BACH1 ncbigene_symbol BACH1 571
Homo sapiens Primates BACH1 BACH1 ncbigene_synonym BRIP1 83990
Homo sapiens Primates MAFF MAFF ncbigene_symbol MAFF 23764
Homo sapiens Primates NRs NRS ncbigene_synonym SPNS1 83985
Homo sapiens Primates out OUT ncbigene_synonym TCF23 150921
Homo sapiens Primates xCT XCT ncbigene_synonym SLC7A11 23657
Homo sapiens Primates GCLM GCLM ncbigene_symbol GCLM 2730
Homo sapiens Primates GCLC GCLC ncbigene_symbol GCLC 2729
Homo sapiens Primates GGT GGT ncbigene_synonym GGT1 2678
Homo sapiens Primates GGT GGT ncbigene_synonym GGTLC5P 653590
Homo sapiens Primates GGT GGT ncbigene_synonym GGTLC3 728226
Homo sapiens Primates GGT GGT ncbigene_synonym GGT2P 728441
Homo sapiens Primates GGT GGT ncbigene_synonym GGTLC4P 729838
Homo sapiens Primates GSS GSS ncbigene_symbol GSS 2937
Homo sapiens Primates GSS GSS ncbigene_synonym PRNP 5621
Homo sapiens Primates GSX GSX ncbigene_synonym ABCC1 4363
Homo sapiens Primates MRP2 MRP2 ncbigene_synonym ABCC2 1244
Homo sapiens Primates MRP2 MRP2 ncbigene_synonym KLHL1 57626
Homo sapiens Primates MRP2 MRP2 ncbigene_synonym SYCE1L 100130958
Homo sapiens Primates GSTS GSTS ncbigene_synonym HPGDS 27306
Homo sapiens Primates GSR GSR ncbigene_symbol GSR 2936
Homo sapiens Primates GPX GPX famplex_relations GPX1 2876
Homo sapiens Primates GPX GPX famplex_relations GPX2 2877
Homo sapiens Primates GPX GPX famplex_relations GPX3 2878
Homo sapiens Primates GPX GPX famplex_relations GPX4 2879
Homo sapiens Primates GPX GPX famplex_relations GPX5 2880
Homo sapiens Primates GPX GPX famplex_relations GPX6 257202
Homo sapiens Primates GPX GPX famplex_relations GPX7 2882
Homo sapiens Primates GPX GPX famplex_relations GPX8 493869
Homo sapiens Primates GLRX GLRX ncbigene_symbol GLRX 2745

Chemical mentions

Word Match MeSH Name ChEBI
Cysteine Cysteine mesh:D003545 cysteine chebi:15356
Cys Cysteine mesh:D003545 cysteine chebi:15356
Glycine Glycine mesh:D005998 glycine chebi:15428
Glutamate NA mesh:D018698
Glu NA mesh:D018698
GSSG Glutathione Disulfide mesh:D019803 glutathione disulfide chebi:17858

Disease mentions

Word Match MeSH Name DOID