The cardiolipin (CL) biosynthetic pathway: PGS1 encodes phosphatidylglycerol phosphate (PGP) synthase, which converts glycerol-3-phosphate (G-3-P) and CDP-diacylglycerol (CDP-DAG) to PGP

The cardiolipin (CL) biosynthetic pathway: PGS1 encodes phosphatidylglycerol phosphate (PGP) synthase, which converts glycerol-3-phosphate (G-3-P) and CDP-diacylglycerol (CDP-DAG) to PGP. PGP is dephosphorylated to phosphatidylglycerol (PG) by PGP phosphatase. CRD1 encodes CL synthase, which converts CDP-DAG and phosphatidylglycerol (PG) to CL. In the proposed remodeling pathway, CL is deacylated to monolysocardiolipin (MLCL) by a phospholipase that has not been identified. MLCL is then reacylated to mature CL by Taz1p.
The cardiolipin (CL) biosynthetic pathway: PGS1 encodes phosphatidylglycerol phosphate (PGP) synthase, which converts glycerol-3-phosphate (G-3-P) and CDP-diacylglycerol (CDP-DAG) to PGP
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Publication

Cellular functions of cardiolipin in yeast. (2009) Amit S. Joshi, et al. Biochim Biophys Acta. 2009 Jan;1793(1):212-218. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PGS1 PGS1 ncbigene_symbol PGS1 42254
Drosophila melanogaster Invertebrates PGP PGP ncbigene_synonym Mdr65 38726
Drosophila melanogaster Invertebrates PG PG ncbigene_symbol pg 252323
Drosophila melanogaster Invertebrates CL CL ncbigene_symbol cl 43938
Drosophila melanogaster Invertebrates MLCL MLCL ncbigene_synonym Mlc1 43323
Homo sapiens Primates PGS1 PGS1 ncbigene_symbol PGS1 9489
Homo sapiens Primates PGS1 PGS1 ncbigene_synonym BGN 633
Homo sapiens Primates PGS1 PGS1 ncbigene_synonym TPGS1 91978
Homo sapiens Primates PGP PGP ncbigene_symbol PGP 283871
Homo sapiens Primates PGP PGP ncbigene_synonym ABCB1 5243
Homo sapiens Primates PGP PGP ncbigene_synonym PGPEP1 54858
Homo sapiens Primates CRD1 CRD1 ncbigene_synonym CORD1 1319
Homo sapiens Primates taz1 TAZ1 ncbigene_synonym TAFAZZIN 6901
Homo sapiens Primates taz1 TAZ1 ncbigene_synonym ZBTB18 10472
Saccharomyces cerevisiae S288C Plants and Fungi PGS1 PGS1 ncbigene_symbol PGS1 850352
Saccharomyces cerevisiae S288C Plants and Fungi CRD1 CRD1 ncbigene_symbol CRD1 851413
Saccharomyces cerevisiae S288C Plants and Fungi taz1 TAZ1 ncbigene_symbol TAZ1 856262

Chemical mentions

Word Match MeSH Name ChEBI
CDP Cytidine Diphosphate mesh:D003565 CDP chebi:17239

Disease mentions

Word Match MeSH Name DOID