TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway

TNF- α–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway. The genes shown in cluster were subjected to functional analysis by using DAVID (NIAID, NIH). One of the major known pathways (KEGG) identified in this category was the focal adhesion pathway, as shown. The gene candidates that were differentially expressed in response to DC are marked with asterisks. DAVID, Database for Annotation, Visualization, and Integrated Discovery; KEGG, Kyoto Encyclopedia of Genes and Genomes. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article at www.liebertonline.com/ars).
TNF- A–inducible genes that were specifically downregulated after DC treatment but not by C95 curcumin: the focal adhesion pathway
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Publication

Neuroprotective and Antiinflammatory Properties of a Novel Demethylated Curcuminoid. (2009) Savita Khanna, et al. Antioxid Redox Signal. 2009 Mar;11(3):449-468. Figure: F10.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Bos taurus Mammals RhoA RHOA ncbigene_symbol RHOA 338049
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 100531842
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 100531971
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 101410076
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 107987640
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 107987645
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 107987895
Bos taurus Mammals MLC MLC ncbigene_symbol MLC 107987897
Bos taurus Mammals MLCK MLCK ncbigene_synonym MYLK 338037
Bos taurus Mammals VASP VASP ncbigene_symbol VASP 514902
Bos taurus Mammals ILK ILK ncbigene_symbol ILK 540207
Bos taurus Mammals PTEN PTEN ncbigene_symbol PTEN 540786
Bos taurus Mammals PI3K PI3K ncbigene_synonym PIK3CB 517948
Bos taurus Mammals Fyn FYN ncbigene_symbol FYN 527263
Bos taurus Mammals Crk CRK ncbigene_symbol CRK 512841
Bos taurus Mammals Ref-1 REF-1 ncbigene_synonym APEX1 281630
Mus musculus Rodents RhoGAP RHOGAP ncbigene_synonym Arhgap36 75404
Mus musculus Rodents RhoGEF RHOGEF ncbigene_synonym Arhgef28 110596
Mus musculus Rodents RhoGEF RHOGEF ncbigene_synonym Arhgef11 213498
Mus musculus Rodents RhoA RHOA ncbigene_symbol Rhoa 11848
Mus musculus Rodents MLC MLC ncbigene_synonym Mlc1 170790
Mus musculus Rodents MLCK MLCK ncbigene_synonym Mylk 107589
Mus musculus Rodents MLCK MLCK ncbigene_synonym Mylk3 213435
Mus musculus Rodents VASP VASP ncbigene_symbol Vasp 22323
Mus musculus Rodents Parvin PARVIN ncbigene_synonym Parva 57342
Mus musculus Rodents Sro SRO ncbigene_synonym Stoml3 229277
Mus musculus Rodents PCB PCB ncbigene_synonym Pcx 18563
Mus musculus Rodents ILK ILK ncbigene_symbol Ilk 16202
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents FAK FAK ncbigene_synonym Ptk2 14083
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents Vav VAV ncbigene_synonym Vav1 22324
Mus musculus Rodents Fyn FYN ncbigene_symbol Fyn 14360
Mus musculus Rodents Crk CRK ncbigene_symbol Crk 12928
Mus musculus Rodents GRF2 GRF2 ncbigene_synonym Rasgrf2 19418
Mus musculus Rodents GRF2 GRF2 ncbigene_synonym Rapgef1 107746
Mus musculus Rodents Rap1 RAP1 ncbigene_synonym Terf2ip 57321
Mus musculus Rodents Rap1 RAP1 ncbigene_synonym Rap1a 109905
Mus musculus Rodents JNK JNK ncbigene_synonym Mapk8 26419
Mus musculus Rodents Sho SHO ncbigene_symbol sho 20428
Mus musculus Rodents Ras RAS ncbigene_symbol ras 19412
Mus musculus Rodents Ras RAS ncbigene_synonym Hras 15461
Mus musculus Rodents Ras RAS ncbigene_synonym Kras 16653
Mus musculus Rodents Ras RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents Ref-1 REF-1 ncbigene_synonym Apex1 11792
Mus musculus Rodents MEK1 MEK1 ncbigene_synonym Map2k1 26395
Mus musculus Rodents Bod BOD ncbigene_synonym Bcl2l11 12125
Homo sapiens Primates RhoGAP RHOGAP ncbigene_synonym ARHGAP1 392
Homo sapiens Primates RhoA RHOA ncbigene_symbol RHOA 387
Homo sapiens Primates MLC MLC ncbigene_synonym MLC1 23209
Homo sapiens Primates actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates MLCK MLCK ncbigene_synonym MYLK 4638
Homo sapiens Primates MLCK MLCK ncbigene_synonym MYLK2 85366
Homo sapiens Primates MLCK MLCK ncbigene_synonym MYLK3 91807
Homo sapiens Primates VASP VASP ncbigene_symbol VASP 7408
Homo sapiens Primates ITGB ITGB famplex_relations ITGB1 3688
Homo sapiens Primates ITGB ITGB famplex_relations ITGB2 3689
Homo sapiens Primates ITGB ITGB famplex_relations ITGB3 3690
Homo sapiens Primates ITGB ITGB famplex_relations ITGB4 3691
Homo sapiens Primates ITGB ITGB famplex_relations ITGB5 3693
Homo sapiens Primates ITGB ITGB famplex_relations ITGB6 3694
Homo sapiens Primates ITGB ITGB famplex_relations ITGB7 3695
Homo sapiens Primates ITGB ITGB famplex_relations ITGB8 3696
Homo sapiens Primates ITGB ITGB famplex_relations ITGBL1 9358
Homo sapiens Primates Sro SRO ncbigene_synonym STOML3 161003
Homo sapiens Primates PCB PCB ncbigene_synonym PC 5091
Homo sapiens Primates ILK ILK ncbigene_symbol ILK 3611
Homo sapiens Primates Wnt WNT famplex_relations WNT1 7471
Homo sapiens Primates Wnt WNT famplex_relations WNT2 7472
Homo sapiens Primates Wnt WNT famplex_relations WNT2B 7482
Homo sapiens Primates Wnt WNT famplex_relations WNT3 7473
Homo sapiens Primates Wnt WNT famplex_relations WNT3A 89780
Homo sapiens Primates Wnt WNT famplex_relations WNT4 54361
Homo sapiens Primates Wnt WNT famplex_relations WNT6 7475
Homo sapiens Primates Wnt WNT famplex_relations WNT7A 7476
Homo sapiens Primates Wnt WNT famplex_relations WNT7B 7477
Homo sapiens Primates Wnt WNT famplex_relations WNT8A 7478
Homo sapiens Primates Wnt WNT famplex_relations WNT8B 7479
Homo sapiens Primates Wnt WNT famplex_relations WNT9A 7483
Homo sapiens Primates Wnt WNT famplex_relations WNT9B 7484
Homo sapiens Primates Wnt WNT famplex_relations WNT10A 80326
Homo sapiens Primates Wnt WNT famplex_relations WNT10B 7480
Homo sapiens Primates Wnt WNT famplex_relations WNT11 7481
Homo sapiens Primates Wnt WNT famplex_relations WNT16 51384
Homo sapiens Primates Wnt WNT famplex_relations WNT5A 7474
Homo sapiens Primates Wnt WNT famplex_relations WNT5B 81029
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates FAK FAK ncbigene_synonym PTK2 5747
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Vav VAV ncbigene_synonym VAV1 7409
Homo sapiens Primates Vav VAV famplex_relations VAV2 7410
Homo sapiens Primates Vav VAV famplex_relations VAV3 10451
Homo sapiens Primates PAK PAK famplex_relations PAK1 5058
Homo sapiens Primates PAK PAK famplex_relations PAK2 5062
Homo sapiens Primates PAK PAK famplex_relations PAK3 5063
Homo sapiens Primates PAK PAK famplex_relations PAK4 10298
Homo sapiens Primates PAK PAK famplex_relations PAK5 57144
Homo sapiens Primates PAK PAK famplex_relations PAK6 56924
Homo sapiens Primates Fyn FYN ncbigene_symbol FYN 2534
Homo sapiens Primates Crk CRK ncbigene_symbol CRK 1398
Homo sapiens Primates GRF2 GRF2 ncbigene_synonym RAPGEF1 2889
Homo sapiens Primates GRF2 GRF2 ncbigene_synonym RASGRF2 5924
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym RAP1A 5906
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym RABGEF1 27342
Homo sapiens Primates Rap1 RAP1 ncbigene_synonym TERF2IP 54386
Homo sapiens Primates Rap1 RAP1 famplex_relations RAP1B 5908
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates Sho SHO ncbigene_synonym SPRN 503542
Homo sapiens Primates Sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates Sos SOS famplex_relations SOS1 6654
Homo sapiens Primates Sos SOS famplex_relations SOS2 6655
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates Ref-1 REF1 ncbigene_synonym APEX1 328
Homo sapiens Primates Ref-1 REF1 ncbigene_synonym TEAD1 7003
Homo sapiens Primates Ref-1 REF1 ncbigene_synonym TFPI2 7980
Homo sapiens Primates MEK1 MEK1 ncbigene_synonym MAP2K1 5604
Homo sapiens Primates Bod BOD ncbigene_synonym BCL2L11 10018
Rattus norvegicus Rodents RhoGAP RHOGAP ncbigene_synonym Dlc1 58834
Rattus norvegicus Rodents RhoA RHOA ncbigene_symbol Rhoa 117273
Rattus norvegicus Rodents MLCK MLCK ncbigene_synonym Mylk2 117558
Rattus norvegicus Rodents MLCK MLCK ncbigene_synonym Mylk3 291926
Rattus norvegicus Rodents VASP VASP ncbigene_symbol Vasp 361517
Rattus norvegicus Rodents ILK ILK ncbigene_symbol Ilk 170922
Rattus norvegicus Rodents Wnt WNT ncbigene_synonym Wnt2 114487
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents FAK FAK ncbigene_synonym Ptk2 25614
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents Vav VAV ncbigene_synonym Vav1 25156
Rattus norvegicus Rodents Fyn FYN ncbigene_symbol Fyn 25150
Rattus norvegicus Rodents cycle CYCLE ncbigene_synonym Ccne1 25729
Rattus norvegicus Rodents Crk CRK ncbigene_symbol Crk 54245
Rattus norvegicus Rodents GRF2 GRF2 ncbigene_synonym Rapgef1 63881
Rattus norvegicus Rodents JNK JNK ncbigene_synonym Mapk8 116554
Rattus norvegicus Rodents Ref-1 REF-1 ncbigene_synonym Apex1 79116
Rattus norvegicus Rodents MEK1 MEK1 ncbigene_synonym Map2k1 170851
Rattus norvegicus Rodents Bod BOD ncbigene_synonym Bcl2l11 64547
Drosophila melanogaster Invertebrates RhoGAP RHOGAP ncbigene_synonym RhoGAP5A 31473
Drosophila melanogaster Invertebrates RhoGAP RHOGAP ncbigene_synonym RhoGAPp190 32743
Drosophila melanogaster Invertebrates RhoGAP RHOGAP ncbigene_synonym RhoGAP68F 39385
Drosophila melanogaster Invertebrates RhoGAP RHOGAP ncbigene_synonym RhoGAP93B 42496
Drosophila melanogaster Invertebrates RhoGAP RHOGAP ncbigene_synonym RhoGAP1A 5740235
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym RtGEF 35306
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym RhoGEF2 36915
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym RhoGEF3 38050
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym RhoGEF64C 38578
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym RhoGEF4 38806
Drosophila melanogaster Invertebrates RhoGEF RHOGEF ncbigene_synonym sif 43892
Drosophila melanogaster Invertebrates RhoA RHOA ncbigene_synonym Rho1 36775
Drosophila melanogaster Invertebrates MLC MLC ncbigene_synonym sqh 31554
Drosophila melanogaster Invertebrates MLC MLC ncbigene_synonym Mlc1 43323
Drosophila melanogaster Invertebrates MLC MLC ncbigene_synonym Mlc2 43587
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act57B 37368
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act79B 40444
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act88F 41885
Drosophila melanogaster Invertebrates actin ACTIN ncbigene_synonym Act87E 48632
Drosophila melanogaster Invertebrates MLCK MLCK ncbigene_synonym Strn-Mlck 36753
Drosophila melanogaster Invertebrates PA PA ncbigene_symbol Pa 251550
Drosophila melanogaster Invertebrates VASP VASP ncbigene_synonym ena 37201
Drosophila melanogaster Invertebrates Talin TALIN ncbigene_synonym rhea 38978
Drosophila melanogaster Invertebrates Parvin PARVIN ncbigene_symbol parvin 32990
Drosophila melanogaster Invertebrates Sro SRO ncbigene_symbol sro 43512
Drosophila melanogaster Invertebrates PCB PCB ncbigene_symbol PCB 36020
Drosophila melanogaster Invertebrates ILK ILK ncbigene_symbol Ilk 53573
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt5 32838
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt4 34007
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym wg 34009
Drosophila melanogaster Invertebrates Wnt WNT ncbigene_synonym Wnt2 35975
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates FAK FAK ncbigene_symbol Fak 37233
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Vav VAV ncbigene_symbol Vav 32920
Drosophila melanogaster Invertebrates PAK PAK ncbigene_symbol Pak 44039
Drosophila melanogaster Invertebrates PAK PAK ncbigene_synonym mbt 32631
Drosophila melanogaster Invertebrates CycD CYCD ncbigene_symbol CycD 32551
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates Crk CRK ncbigene_symbol Crk 43775
Drosophila melanogaster Invertebrates Crk CRK ncbigene_synonym NA 32026
Drosophila melanogaster Invertebrates Rap1 RAP1 ncbigene_symbol Rap1 38244
Drosophila melanogaster Invertebrates JNK JNK ncbigene_synonym bsk 44801
Drosophila melanogaster Invertebrates C3G C3G ncbigene_symbol C3G 31618
Drosophila melanogaster Invertebrates C3G C3G ncbigene_synonym c(3)G 47765
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Tie 38559
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym InR 42549
Drosophila melanogaster Invertebrates Sho SHO ncbigene_symbol sho 252636
Drosophila melanogaster Invertebrates Sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ha HA ncbigene_symbol ha 251217
Drosophila melanogaster Invertebrates HaRas HARA ncbigene_synonym na 45338
Drosophila melanogaster Invertebrates Ref-1 REF1 ncbigene_symbol Ref1 44029
Drosophila melanogaster Invertebrates Bod BOD ncbigene_symbol bod 247919

Chemical mentions

Word Match MeSH Name ChEBI
Ala Alanine mesh:D000409 alanine chebi:16449
Phosphatidyl inositol Phosphatidylinositols mesh:D010716 1-phosphatidyl-1D-myo-inositol chebi:16749

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Lung cancer NA
Noonan syndrome NA