The complement cascade

Schematic representation of the complement cascade. The various activation pathways are underlined and the heavy lines and arrows showed the progression in the cascade of activation. There are three activation pathways that converge to a common pathway to further progress into a terminal pathway. The names of the various inhibitors are in italics with dotted arrows pointing to their site of action. C4bBP C4b-binding protein; C1-INH C1-esterase inhibitor; CR1 Complement receptor 1; DAF Decay-accelerating factor; Factor P Properdin; HRF Homologous restriction factor; MASP Mannan-binding lectin (MBL)-associated serine protease; MCP Membrane cofactor protein; Protein S Vitronectin; SP-40 Clusterin
The complement cascade
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Publication

Complement activity and pharmacological inhibition in cardiovascular disease. (2006) Pierre Théroux, et al. Can J Cardiol. 2006 Feb;22(Suppl B):18B-24B. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates C1q C1Q famplex_relations C1QA 712
Homo sapiens Primates C1q C1Q famplex_relations C1QB 713
Homo sapiens Primates MBL MBL ncbigene_synonym MBL2 4153
Homo sapiens Primates MBL MBL ncbigene_synonym MBL3P 50639
Homo sapiens Primates C4b C4B ncbigene_symbol C4B 721
Homo sapiens Primates C4a C4A ncbigene_symbol C4A 720
Homo sapiens Primates MASP-1 MASP1 ncbigene_symbol MASP1 5648
Homo sapiens Primates Cir CIR ncbigene_synonym KCNJ5 3762
Homo sapiens Primates Cir CIR ncbigene_synonym CIR1 9541
Homo sapiens Primates Cir CIR ncbigene_synonym VIM2P 100130535
Homo sapiens Primates C1s C1S ncbigene_symbol C1S 716
Homo sapiens Primates C2 C2 ncbigene_symbol C2 717
Homo sapiens Primates C1-INH C1INH ncbigene_synonym SERPING1 710
Homo sapiens Primates MASP-2 MASP-2 ncbigene_synonym MASP2 10747
Homo sapiens Primates C2b C2B ncbigene_synonym SCGB2B3P 100130342
Homo sapiens Primates СЗ C3 ncbigene_symbol C3 718
Homo sapiens Primates C5 C5 ncbigene_symbol C5 727
Homo sapiens Primates CR1 CR1 ncbigene_symbol CR1 1378
Homo sapiens Primates CR1 CR1 ncbigene_synonym CRIPTO 6997
Homo sapiens Primates MCP MCP ncbigene_synonym CAPG 822
Homo sapiens Primates MCP MCP ncbigene_synonym CD46 4179
Homo sapiens Primates DAF DAF ncbigene_synonym CD55 1604
Homo sapiens Primates C6 C6 ncbigene_symbol C6 729
Homo sapiens Primates SP-40 SP-40 ncbigene_synonym CLU 1191
Homo sapiens Primates C7 C7 ncbigene_symbol C7 730
Homo sapiens Primates HRF HRF ncbigene_synonym TPT1 7178
Homo sapiens Primates C9 C9 ncbigene_symbol C9 735

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID